Two-parameter dynamics and multistability of a non-smooth railway wheelset system with dry friction damping.

A deep understanding of non-smooth dynamics of vehicle systems, particularly with dry friction damping offer valuable insights into the design and optimization of railway vehicle systems, ultimately enhancing the safety and reliability of railway operations. In this paper, the two-parameter dynamics of a non-smooth railway wheelset system incorporating dry friction damping are investigated. The effect of the crucial parameters on the complexity of the evolution process is comprehensively exposed by identifying different dynamic responses in the two-parameter plane.

Integrated Identification and Immunotherapy Response Analysis of the Prognostic Signature Associated With m6A, Cuproptosis-Related, Ferroptosis-Related lncRNA in Endometrial Cancer.

Background: Endometrial cancer (EC) stands as the predominant gynecological malignancy impacting the female reproductive system on a global scale. N6-methyladenosine, cuproptosis- and ferroptosis-related biomarker is beneficial to the prognostic of tumor patients. Nevertheless, the correlation between m6A-modified lncRNAs and ferroptosis, copper-induced apoptosis in the initiation and progression of EC remains unexplored in existing literature.

Prevalence and factors influencing long COVID among primary healthcare workers after epidemic control policy adjustment in Jiangsu, China.

Objective: The persistent symptoms arising from COVID-19 infection pose a substantial threat to patients' health, carrying significant implications. Amidst the evolving COVID-19 control strategies in China, healthcare workers (HCWs) endure considerable stress. This study aims to evaluate the prevalence of long COVID infections and their influencing factors among primary HCWs after epidemic control policy adjustment in Jiangsu.

A propensity score matched analysis of COVID-19 ongoing symptoms in primary medical staff members with different levels of stress in Jiangsu Province, China.

Objective: Ongoing symptoms which originated from coronavirus disease 2019 (COVID-19) infections threaten the health of a broad population of patients. With recent changes in COVID-19 control measures in China, medical staff members are currently experiencing a high level of stress. This study aimed to investigate the prevalence of ongoing symptomatic COVID-19 and explore the potential association between stress and ongoing COVID symptoms.

Duration and severity of COVID-19 symptoms among primary healthcare workers: A cross-sectional survey.

Aims: This study aims to investigate the epidemiological characteristics of COVID-19 infection among healthcare workers, including the severity, duration of infection, post-infection symptoms and related influencing factors.

Methods: A self-administered questionnaire was utilized to assess the post-infection status of primary healthcare workers in Jiangsu Province. The questionnaire collected information on demographic characteristics, lifestyle habits, post-infection clinical manifestations, work environment and recovery time of the respondents.

Zinc Doping Induces Enhanced Thermoelectric Performance of Solvothermal SnTe.

The creation of hierarchical nanostructures can effectively strengthen phonon scattering to reduce lattice thermal conductivity for improving thermoelectric properties in inorganic solids. Here, we use Zn doping to induce a remarkable reduction in the lattice thermal conductivity in SnTe, approaching the theoretical minimum limit. Microstructure analysis reveals that ZnTe nanoprecipitates can embed within SnTe grains beyond the solubility limit of Zn in the Zn alloyed SnTe.

Primary healthcare workers' COVID-19 infection status following implementation of adjusted epidemic prevention and control strategies: a cross-sectional study in Jiangsu, China.

Introduction: In times of epidemic outbreaks, healthcare workers (HCWs) emerge as a particularly vulnerable group. This cross-sectional study endeavors to assess the COVID-19 infection rate among the primary HCWs in Jiangsu Province subsequent to the implementation of adjusted epidemic prevention and control strategies.

Methods: From January 17 to February 2, 2023, an extensive survey was conducted among primary HCWs in Jiangsu Province, employing a self-designed questionnaire.

Modelling the capacitance of the elongated plasma in tokamak.

The capacitance model suitable for the non-circular cross-section plasma is studied based on the capacitance model of the circular cross-section plasma. The coaxial elliptic-torus capacitor property is further derived and used to determine the capacity of non-circular cross-section tokamak plasma, such as EAST (Experimental Advanced Superconducting Tokamak). By testing all the physical terms in this model, we find that the capacitance [Formula: see text]) is increasing exponentially with the increase of elongation ratio (k/k), while the minor radius ratio (a/a) is just reversed at the flat-top of plasma current, and the capacitance property is implicitly included in the H-mode study during the L-H transition.

Efficacy and Safety of Niraparib as First-Line Maintenance Treatment for Patients with Advanced Ovarian Cancer: Real-World Data from a Multicenter Study in China.

Background: Poly (ADP-ribose) polymerase (PARP) inhibitors are a new maintenance therapy option for patients with ovarian cancer (OC).

Objective: To evaluate the efficacy and influencing factors of the novel PARP inhibitor niraparib for maintenance treatment of Chinese patients with advanced OC.

Patients And Methods: In this retrospective multicenter real-world study patients with advanced OC from 15 hospitals throughout China were enrolled.

A novel genes-based signature with prognostic value and predictive ability to select patients responsive to Atezolizumab treatment in bladder cancer: an analysis on data from real-world studies.

Background: There is a lack of molecular markers that effectively predict response to treatment with immune checkpoint inhibitors in patients with uroepithelial bladder carcinoma. The purpose of this study was to explore molecular markers that effectively predict the efficacy of Atezolizumab in the treatment of uroepithelial bladder carcinoma based on real-world clinical trial data.

Methods: Gene expression and clinical information of two groups of patients in two datasets, IMvigor210 and GSE176307, who were treated effectively and ineffectively with the programmed cell death 1 ligand 1 (PD-L1) inhibitor Atezolizumab, were obtained.

Stability and Bautin bifurcation of four-wheel-steering vehicle system with driver steering control.

In this paper, the stability and Bautin bifurcation of a four-wheel-steering (4WS) vehicle system, by considering driver steering control, are investigated. By using the central manifold theory and projection method, the first and second Lyapunov coefficients are calculated to predict the type of Hopf bifurcation of the vehicle system. The topological structure of Bautin bifurcation, a degenerate Hopf bifurcation of the 4WS vehicle system, is presented in parameter space, and it reveals the dynamics of the vehicle system of different choices of control parameters.

Chemically Recyclable Biobased Non-Isocyanate Polyurethane Networks from CO -Derived Six-membered Cyclic Carbonates.

Non-isocyanate polyurethanes (NIPUs) are widely studied as sustainability potential, because they can be prepared without using toxic isocyanates in the synthesis process. The aminolysis of cyclic carbonate to form NIPUs is a promising route. In this work, a series of NIPUs is prepared from renewable bis(6-membered cyclic carbonates) (iEbcc) and amines.

Mechanically Robust and Chemically Recyclable Polyhydroxyurethanes from CO-Derived Six-Membered Cyclic Carbonates.

In the current context of sustainable chemistry development and new regulations, aminolysis of cyclic carbonate is one of the most promising routes to nonisocyanate polyurethanes, also called polyhydroxyurethanes (PHU). In this study, a new kind of shape memory PHU vitrimers with outstanding mechanical properties and chemical recyclability is prepared. The monomer employed for aminolysis to form the PHUs is bis(six-membered cyclic carbonate) of 4,4'-biphenol (BCC-BP), which is synthesized by bi(1,3-diol) precursors and CO.

An Unsupervised Deep Learning-Based Model Using Multiomics Data to Predict Prognosis of Patients with Stomach Adenocarcinoma.

Methods: Patients (363 in total) with stomach adenocarcinoma from The Cancer Genome Atlas (TCGA) cohort were included. An autoencoder was constructed to integrate the RNA sequencing, miRNA sequencing, and methylation data. The features of the bottleneck layer were used to perform the -means clustering algorithm to obtain different subgroups for evaluating the prognosis-related risk of stomach adenocarcinoma.

Interactions of circRNAs with methylation: An important aspect of circRNA biogenesis and function (Review).

Circular RNA (circRNA) molecules are noncoding RNAs with unique circular covalently closed structures that contribute to gene expression regulation, protein translation and act as microRNA sponges. circRNAs also have important roles in human disease, particularly tumorigenesis and antitumor processes. Methylation is an epigenetic modification that regulates the expression and roles of DNA and coding RNA and their interactions, as well as of noncoding RNA molecules.

Biodegradable Ru-Containing Polycarbonate Micelles for Photoinduced Anticancer Multitherapeutic Agent Delivery and Phototherapy Enhancement.

The lack of selectivity between tumor and healthy cells, along with inefficient reactive oxygen species production in solid tumors, are two major impediments to the development of anticancer Ru complexes. The development of photoinduced combination therapy based on biodegradable polymers that can be light activated in the "therapeutic window" would be beneficial for enhancing the therapeutic efficacy of Ru complexes. Herein, a biodegradable Ru-containing polymer (poly(DCARu)) is developed, in which two different therapeutics (the drug and the Ru complex) are rationally integrated and then conjugated to a diblock copolymer (MPEG-b-PMCC) containing hydrophilic poly(ethylene glycol) and cyano-functionalized polycarbonate with good degradability and biocompatibility.

Role of Hub Genes in the Occurrence and Development of Testicular Cancer Based on Bioinformatics.

Background: Testicular cancer severely affects male health, so finding effective diagnosis and prognostic indicators and exploring its pathogenesis are very important.

Purpose: This study aims to explore the hub genes that play important roles in the occurrence and development of testicular germ cell tumor (TGCT).

Methods: Data were obtained from Gene Expression Omnibus datasets (GSE3218 and GSE1818) and verified in The Cancer Genome Atlas database and the Genotype-Tissue Expression database and the Human Protein Atlas database.

A Sequential Dual-Model Strategy Based on Photoactivatable Metallopolymer for On-Demand Release of Photosensitizers and Anticancer Drugs.

The synergistic combination of chemotherapy and photodynamic therapy has attracted considerable attention for its enhanced antitumoral effects; however, it remains challenging to successfully delivery photosensitizers and anticancer drugs while minimizing drug leakage at off-target sites. A red-light-activatable metallopolymer, Poly(Ru/PTX), is synthesized for combined chemo-photodynamic therapy. The polymer has a biodegradable backbone that contains a photosensitizer Ru complex and the anticancer drug paclitaxel (PTX) via a singlet oxygen ( O ) cleavable linker.

Dual-angle technique for simultaneous measurement of refractive index and temperature based on a surface plasmon resonance sensor.

We describe a theoretical model to analyze temperature effects on the Kretschmann surface plasmon resonance (SPR) sensor, and describe a new double-incident angle technique to simultaneously measure changes in refractive index (RI) and temperature. The method uses the observation that output signals obtained from two different incident angles each have a linear dependence on RI and temperature, and are independent. A proof-of-concept experiment using different NaCl concentration solutions as analytes demonstrates the ability of the technique.

Symmetry restoring bifurcations and quasiperiodic chaos induced by a new intermittency in a vibro-impact system.

Quasiperiodic chaos (QC), which is a combination of quasiperiodic sets and a chaotic set, is uncovered in the six dimensional Poincaré map of a symmetric three-degree of freedom vibro-impact system. Accompanied by symmetry restoring bifurcation, this QC is the consequence of a novel intermittency that occurs between two conjugate quasiperiodic sets and a chaotic set. The six dimensional Poincaré map P is the 2-fold composition of another virtual implicit map Q, yielding the symmetry of the system.

[Experimentation and investigation of the effects of TNF and the acceptor expression in renal early trauma with extraneous adrenomedullin].

Objective: To investigate the effects of TNF-alpha, TNF-beta and the acceptor expression about mechanical renal trauma with extraneous ADM.

Methods: There were 104 healthy adult plain grade Wistar rat, randomly divided into four groups:8 in the group of control, 32 in the group of trauma, 32 in the group injected ADM before trauma, 32 in the group injected ADM post trauma. The experimental model of rat kidney with mechanical trauma was prepared by striking the area of rat skin reflecting by kidney with free dropping ferrous hammer in the last three groups.