The role of ACER2 in intestinal sphingolipid metabolism and gastrointestinal cancers.

Sphingolipids, particularly sphingosine-1-phosphate (S1P), are bioactive lipids involved in regulating cellular processes such as proliferation, apoptosis, inflammation, and tumor progression. Alkaline ceramidase 2 (ACER2) plays a critical role in sphingolipid metabolism by catalyzing the hydrolysis of ceramide to sphingosine, which is subsequently converted to S1P. Dysregulation of ACER2 has been implicated in various gastrointestinal cancers, including colorectal cancer, gastric cancer, and hepatocellular carcinoma.

Joint Under-Sampling Pattern and Dual-Domain Reconstruction for Accelerating Multi-Contrast MRI.

Multi-Contrast Magnetic Resonance Imaging (MCMRI) utilizes the short-time reference image to facilitate the reconstruction of the long-time target one, providing a new solution for fast MRI. Although various methods have been proposed, they still have certain limitations. 1) existing methods featuring the preset under-sampling patterns give rise to redundancy between multi-contrast images and limit their model performance; 2) most methods focus on the information in the image domain, prior knowledge in the k-space domain has not been fully explored; and 3) most networks are manually designed and lack certain physical interpretability.

Design, synthesis and biological evaluation of 2,4,6- trisubstituted triazine derivatives as new nonpeptide small-molecule SIRT5 inhibitors.

Human sirtuin 5 (SIRT5) participates in a variety of metabolic disorder-associated diseases, including cancer. Inhibition of SIRT5 has been confirmed to provide a new strategy for treatment of related diseases. Previously, we discovered a pyrimidine skeleton inhibitor XIV, which showed low micromolar inhibitory activity against SIRT5.

Structure-Activity Relationship Studies of 2,4,5-Trisubstituted Pyrimidine Derivatives Leading to the Identification of a Novel and Potent Sirtuin 5 Inhibitor against Sepsis-Associated Acute Kidney Injury.

Sepsis-associated acute kidney injury (AKI) is a serious clinical problem without effective drugs. Inhibition of sirtuin 5 (SIRT5) has been confirmed to protect against AKI, suggesting that SIRT5 inhibitors might be a promising therapeutic approach for AKI. Herein, structural optimization was performed on our previous compound (IC = 3.

DNA-Programmable AgAuS-Primed Conductive Nanowelding Wires-Up Wet Colloids.

Self-assembly of nanomaterials, directed by molecular or supramolecular interactions, is a powerful strategy to build nanoscale devices. Despite many advantages of such solution-based processes, a big challenge is to realize interparticle ohmic contacts toward facilitated charge transport over a long distance. We report a new concept of primed nanowelding to thread solution-borne nanoparticles in prescribed assemblies.

Decoupled Roles of DNA-Surfactant Interactions: Instant Charge Inversion, Enhanced Colloidal and Chemical Stabilities, and Fully Tunable DNA Conjugation of Shaped Plasmonic Nanocrystals.

Surfactant-dictated syntheses of nanomaterials with well-defined shapes offer an extra dimension of control beyond nanoparticle size and chemical composition on the properties and self-assembly behaviors of colloidal materials. However, the surfactant bilayers on nanocrystals often cause great difficulty toward DNA grafting due to their unfavorable electrostatic charges and dense surface packing. Herein a revisit to this dilemma unveils a rapid charge inversion and enhanced colloidal/chemical stabilities of cationic-bilayer-covered nanocrystals upon DNA adsorption.

Boosting framework via clinical monitoring data to predict the depth of anesthesia.

Background: Prediction of the depth of anesthesia is a difficult job in the biomedical field.

Objective: This study aimed to build a boosting-based prediction model to predict the depth of anesthesia based on four clinical monitoring data.

Methods: Boosting is a framework algorithm that is used to train a series of weak learners into strong learners by assigning different weights according to their classification accuracy.

5-HTT, BMPR2, EDN1, ENG, KCNA5 gene polymorphisms and susceptibility to pulmonary arterial hypertension: A meta-analysis.

Background: The influence of 5-HTT, BMPR2, EDN1, ENG, KCNA5 genes polymorphisms on susceptibility of pulmonary arterial hypertension remains uncertain. This meta-analysis is conducted for further study.

Methods: We conducted a literature search on PubMed and ISI web of science databases for searching relevant articles until November 2017.

Identification of four novel XPC mutations in two xeroderma pigmentosum complementation group C patients and functional study of XPC Q320X mutant.

Xeroderma pigmentosum (XP) is a rare, recessive hereditary disease characterized by sunlight hypersensitivity and high incidence of skin cancer with clinical and genetic heterogeneity. We collected two unrelated Chinese patients showing typical symptoms of XPC without neurologic symptoms. Direct sequencing of XPC gene revealed that patient 1 carried IVS1+1G>A and c.

Genotype-phenotype correlation in Chinese patients with dystrophic epidermolysis bullosa pruriginosa.

Dystrophic epidermolysis bullosa pruriginosa (DEB-Pr) is a rare variant of dystrophic epidermolysis bullosa (DEB) due to dominant or recessive mutations in the COL7A1 gene. More than 40 mutations in COL7A1 have been described in DEB-Pr. The aim of this study was to understand the genotype-phenotype correlation in Chinese patients with DEB-Pr.

[Therapeutic efficiency of amphotericin B liposome modified by RMP-7 to transport drug across blood brain barrier].

Aim: To study the therapeutic efficiency of amphotericin B liposome (AmB-L) targeting to the brain in mice with meningitis.

Methods: Amphotericin B liposome targeting to the brain were prepared by film-sonication method. Their concentration and encapsulation percentage were determined.

Histopathologic and scanning electron microscope examination of the nail and hair in chronic mucocutaneous candidiasis.

The case of a 4-year-old boy with chronic mucocutaneous candidiasis is reported. Nail sections stained with periodic acid-Schiff and Grocott-Gomori methenamine-silver showed pseudohyphae running haphazardly within the nail. Scanning electron microscopy showed hyphae penetrating into the nail plate and the hair shaft.