Identification of Synergies in Fe, Co-Coordinated Polyphthalocyanines Scaffolds for Electrochemical CO Reduction Reaction.

The synergistic interaction between the isolated metal sites promoted the electrocatalytic activity of the catalysts. However, the structural heterogeneity of the isolated sites makes it challenging to evaluate this effect accurately. In this work, metal-coordinated polyphthalocyanine molecules (Fe-PPc, Co-PPc, FeCo-PPc) with long-range ordered and precise coordination structures are used as a platform to study the synergies of different isolated metal sites in the electrochemical CO reduction reaction.

Carbon-Doped Nickle Via a Fast Decarbonization Route for Enhanced Hydrogen Oxidation Reaction in Alkaline Media.

Nickel (Ni) based materials with non-metal heteroatom doping are competitive substitutes for platinum group catalyst toward alkaline hydrogen oxidation reaction (HOR). However, the incorporation of non-metal atom into the lattice of conventional fcc phase Ni can easily trigger a structural phase transformation, forming hcp phase nonmetallic intermetallic compounds. Such tangle phenomenon makes it difficult to uncover the relationship between HOR catalytic activity and doping effect on fcc phase Ni.

[Preparation of humanized anti-tissue factor antibody and its mechanism of killing colon cancer cells and inhibiting cell migration].

Objective To investigate the killing effect of humanized antibodies targeting tissue factors on colon cancer cells as well as migration-inhibiting effect. Methods Humanized anti-tissue factor antibody was purified by Protein A and gel filtration chromatography from cultured CHO-5G4.1 cells that highly express the antibody.

Design, Synthesis, and Preliminary Bioactivity Evaluation of 2,7-Substituted Carbazole Derivatives as Potent Autotaxin Inhibitors and Antitumor Agents†.

Background: Autotaxin-LPA signaling has been implicated in cancer progression, and targeted for the discovery of cancer therapeutic agents.

Objective: Potential ATX inhibitors were synthesized to develop novel leading compounds and effective anticancer agents.

Methods: The present work designs and synthesizes a series of 2,7-subsitituted carbazole derivatives with different terminal groups R [R = -Cl (I), -COOH (II), -B(OH)2 (III), or -PO(OH)2 (I-IV)].

[Preparation and characterization of a monoclonal antibody against human tissue factor with anticoagulation activity].

Objective: To prepare and characterize a monoclonal antibody (mAb) against human tissue factor (hTF) with anticoagulation activity.

Methods: BALB/c mice were immunized with truncated recombinant protein (rhTF243). Hybridoma cell lines were generated from cell fusion, and screened using indirect ELISA and prothrombin time (PT).