Publications by authors named "Pengchao Yang"
Article Synopsis
- The study aimed to compare the effectiveness of oblique lumbar interbody fusion (OLIF) and transforaminal lumbar interbody fusion (TLIF) in treating complex degenerative lumbar spondylolisthesis (CDLS) by examining spinopelvic parameters and clinical outcomes.
- A total of 71 patients underwent either OLIF (31 patients) or TLIF (40 patients) from January 2018 to December 2020, with results showing that OLIF had lower postoperative C-reactive protein levels, shorter hospital stays, and better correction rates of slippage compared to TLIF.
- OLIF also demonstrated better long-term improvements in spinopelvic parameters, such as lumbar lordosis angle and pelvic
Activating Nrf2 by small molecules is a promising strategy to treat postmenopausal osteoporosis. However, there is currently no Nrf2 activator approved for treating chronic diseases, and the downstream mechanism underlying the regulation of Nrf2 on osteoclast differentiation remains unclear. Here, we found that bitopertin, a clinical-stage glycine uptake inhibitor, suppresses osteoclast differentiation and ameliorates ovariectomy-induced bone loss by activating Nrf2.
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