Decoding mA RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance.

N-methyladenosine (mA) is a common chemical modification for mammalian mRNA and exhibits high dynamics in various biological processes. However, dynamics of mA RNA methylome during leukemogenesis remains unknown. Here, we delineate a comprehensive mA landscape during acute myeloid leukemia (AML) development and identify PRMT6 as a key for maintaining AML stem cells.

RNA mA Modification Plays a Key Role in Maintaining Stem Cell Function in Normal and Malignant Hematopoiesis.

N-methyladenosine (mA) is a commonly modification of mammalian mRNAs and plays key roles in various cellular processes. Emerging evidence reveals the importance of RNA mA modification in maintaining stem cell function in normal hematopoiesis and leukemogenesis. In this review, we first briefly summarize the latest advances in RNA mA biology, and further highlight the roles of mA writers, readers and erasers in normal hematopoiesis and acute myeloid leukemia.

Access to Multisubstituted 2(5 H)-Furanones Using Hydrogen Bonding-Promoted Ring-Closing Metathesis and Polyamine Workup.

Structurally complex 2(5 H)-furanones are potentially challenging targets for ring-closing metathesis (RCM). A hydrogen bonding-guided RCM strategy was developed in this study to provide 3-substituted and 3,4-disubstituted 2(5 H)-furanones in moderate to high yields with broad functional group tolerance. A workup procedure using ethylenediamine-derived polyamines such as tetraethylenepentylamine was also established to effectively remove Ru residues in products.

Rapid fabrication of transparent film directly from wood fibers with microwave-assisted ionic liquids technology.

Presently flexibly transparent film or nanopaper from all cellulose was mostly fabricated by assembling cellulose nanofibers disintegrated from macroscopic wood fibers which mostly suffers from potential environmental toxicity or high cost. In this work, we firstly reported an all-cellulose transparent film fabricated by a novel microwave-assisted ionic liquids technology (MILT). The use of MILT for treating the original all-cellulose paper brings nearly 2.

Rapid ILs-polishing Processes Toward Flexible Nanostructured Paper with Dually High Transparency and Haze.

Biodegradable highly nanostructured paper has received great interest in past years due to its excellent optical properties which facilitate its wide applications in green flexible electronics and devices. However, energy and/or time-consuming procedure during the process of fabricating most nanostructured transparent paper are presently the main obstacle to their scalable production. In this work, we demonstrated a novel nanostructured paper with dually high transparency (∼91%) and high haze (∼89%) that was directly fabricated from original paper with rapid ILs-polishing processes.

Transparent Electrode and Magnetic Permalloy Made from Novel Nanopaper.

We report a novel partial dissolution strategy to liberate uniform cellulose nanofibers with diameter of 5-10 nm from macroscopic cellulose fibers and promote separation of nanofibers in an aqueous environment by forming water-soluble sodium carboxymethylcellulose (CMC) through heterogeneous sodium acetoxylation of cellulose. With the obtained cellulose nanofibers, we fabricated nanopapers which exhibit high optical transparency of 90.5% (@550 nm) with promising mechanical properties and high thermal stability.

Rapid Dissolving-Debonding Strategy for Optically Transparent Paper Production.

Transparent paper is an alternative substrate for electronic devices due to its unique properties. However, energy-intensive and/or time-consuming procedures currently limit the scalable production of transparent paper. In this report, we demonstrate a rapid process to fabricate optically transparent paper with regenerative cellulose fibers (RCFs) by employing a dissolving-debonding strategy.