Cancer cell-extrinsic STING shapes immune-active microenvironment and predicts clinical outcome in gastric cancer.

Purpose: The activation of cGAS-STING pathway can be triggered by cytosolic double-stranded DNA (dsDNA) in tumor and non-tumor compartments. We aim to assess the constitutive expression of dsDNA-cGAS-STING axis in different cellular contexts and compare their relative contribution to clinical outcomes.

Methods: A cohort of 154 cases of patients with newly diagnosed gastric cancer were enrolled in this study to evaluate the histo-score of cytosolic dsDNA, cGAS, and STING via immunohistochemistry as well as the types and densities of tumor-infiltrating immune cells.

Co-adsorption enhancement of formaldehyde/carbon dioxide over modified hexagonal boron nitride for whole-surface capture purification.

Simultaneous capture of formaldehyde (HCHO) and carbon dioxide (CO) in indoor air is promising of achieving indoor-air purification. Of all potential adsorbents, hexagonal boron nitride (h-BN) is one of the most suitable species owing to facile formation of attraction points. Therefore, in this study, performances of HCHO and CO being adsorbed over pure/modified h-BN are systematically investigated via density functional theory (DFT) calculations.

Relating Tabooness to Humor and Arousal Ratings in American English: What the F*** Is so Funny?

Emotion can have a profound effect on language processing, and taboo words have been increasingly used in research as highly emotional, negatively valenced stimuli. However, because taboo words as a lexical category are socially constructed and semantically idiosyncratic, they may also have complex emotional characteristics. This complexity may not be fully considered by researchers using taboo words as research stimuli.

Identification of molecular pattern and prognostic risk model based on ligand-receptor pairs in liver cancer.

Introduction: The tumor microenvironment of hepatocellular carcinoma is composed of multiple cells, and the interactive communication between cells drives tumor progression and characterizes the tumor. Communication between cells is mainly achieved through signal transduction between receptor ligands, and the rise of single-cell technology has made it possible to analyze the communication network between cells.

Methods: We applied a train of bioinformatic techniques and in vitro experiments.

Research on nonsteady-state adsorption and regulation towards stabler adsorption for benzene over single-wall carbon materials.

With the intention of separating benzene (CH) from indoor polluted air and collecting it in a cleaner way, it is promising of getting CH adsorbed on activated carbon materials with outstanding physicochemical properties. In this study, how CH is adsorbed over single-wall carbon materials and relevant adsorption processes are enhanced is thoroughly investigated via density functional theory (DFT). Especially, distinction between partial and whole effects of adsorbents on CH adsorption, features of electron distribution across section of adsorption forms, and regulation mechanism of nonsteady-state adsorption for CH are key points.

Macrophage metabolism reprogramming EGCG-Cu coordination capsules delivered in polyzwitterionic hydrogel for burn wound healing and regeneration.

Excessive reactive oxygen species (ROS) at severe burn injury sites may promote metabolic reprogramming of macrophages to induce a deteriorative and uncontrolled inflammation cycle, leading to delayed wound healing and regeneration. Here, a novel bioactive, anti-fouling, flexible polyzwitterionic hydrogel encapsulated with epigallocatechin gallate (EGCG)-copper (Cu) capsules (termed as EGCG-Cu@CB) is engineered for burn wound management, which is dedicated to synergistically exerting ROS-scavenging, immune metabolic regulation and pro-angiogenic effects. EGCG-Cu@CB can scavenge ROS to normalize intracellular redox homeostasis, effectively relieving oxidative damages and blocking proinflammatory signal transduction.

Diagnostic and prognostic value of deregulated long non-coding RNA RPPH1 in patients with severe community-acquired pneumonia: a retrospective cohort study.

Background: Severe community-acquired pneumonia (SCAP) is one of the most common critical and acute diseases in the respiratory and acute medicine department. The expression and significance of lncRNA RPPH1 (RPPH1) in SCAP were assessed aiming to explore a biomarker assisting in the screening and management of SCAP.

Methods: This study is a retrospective study enrolled 97 SCAP patients, 102 mild community-acquired pneumonia (MCAP) patients, and 65 healthy individuals.

Development and validation of a contrast-enhanced CT-based radiomics nomogram for preoperative diagnosis in neuroendocrine carcinoma of digestive system.

Objectives: To develop and validate a contrast-enhanced CT-based radiomics nomogram for the diagnosis of neuroendocrine carcinoma of the digestive system.

Methods: The clinical data and contrast-enhanced CT images of 60 patients with pathologically confirmed neuroendocrine carcinoma of the digestive system and 60 patients with non-neuroendocrine carcinoma of the digestive system were retrospectively collected from August 2015 to December 2021 at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, and randomly divided into a training cohort (n=84) and a validation cohort (n=36). Clinical characteristics were analyzed by logistic regression and a clinical diagnosis model was developed.

Tanshinone IIA and hepatocellular carcinoma: A potential therapeutic drug.

Because of its high prevalence and poor long-term clinical treatment effect, liver disease is regarded as a major public health problem around the world. Among them, viral hepatitis, fatty liver, cirrhosis, non-alcoholic fatty liver disease (NAFLD), and autoimmune liver disease are common causes and inducements of liver injury, and play an important role in the occurrence and development of hepatocellular carcinoma (HCC). Tanshinone IIA (TsIIA) is a fat soluble polyphenol of Salvia miltiorrhiza that is extracted from Salvia miltiorrhiza.

FGFR2 upregulates PAI-1 via JAK2/STAT3 signaling to induce M2 polarization of macrophages in colorectal cancer.

Fibroblast growth factor receptor 2 (FGFR2) is frequently activated by overexpression or mutation, and an abnormal fibroblast growth factor (FGF)/FGFR signaling pathway is associated with the occurrence, development, and poor prognosis of colorectal cancer (CRC). Our preliminary analysis found that plasminogen activator inhibitor-1 (PAI-1) expression may be related to FGF/FGFR signaling, however, their role in the tumor immune microenvironment remains unclear. In this study, we observed markedly higher PAI-1 expression in CRC patients with poor survival rates.

Identification of molecular patterns and prognostic models of epithelial-mesenchymal transition- and immune-combined index in the gastric cancer.

Epithelial-mesenchymal transition (EMT) and the immune microenvironment play important roles in the progression of gastric cancer (GC), but the joint role of both in GC is not clear. We identified EMT- and immune-related genes (EIRGs), and the molecular subtypes of EIRGs were identified by unsupervised cluster analysis. Then, we constructed an accurate EIRG_score model by using differential genes of molecular subtypes.

Pan-Cancer Analysis of OLFML2B Expression and Its Association With Prognosis and Immune Infiltration.

The function of olfactomedin-like 2B (OLFML2B), as a member of the olfactomedin domain-containing protein family, remains ambiguous, especially in tumors. The current study explores the possible correlation between OLFML2B, prognosis, and immune infiltration in pan-cancer. We applied a number of bioinformatics techniques to probe the prospective function of OLFML2B, consisting of its association with prognosis, clinicopathology, alteration, GSEA, tumor microenvironment (TME), immune-associated genes, immune infiltration, tumor mutational burden (TMB), microsatellite instability (MSI), and drug sensitivity in several cancer types.

KIF2C is a Biomarker Correlated With Prognosis and Immunosuppressive Microenvironment in Human Tumors.

Kinesin superfamily member 2C (KIF2C) is an essential regulator of the cell cycle and its aberrant expression can promote tumor progression. However, the mechanism of KIF2C in pan-cancer is unclear.Data were obtained from public databases, including The Cancer Genome Atlas (TCGA), UALCAN, TIMER and CellMiner.

Fe-Catalyzed CO Adsorption over Hexagonal Boron Nitride with the Presence of HO.

The energy barrier of CO chemically adsorbed on hexagonal boron nitride (h-BN) is relatively big. In order to cut down the energy barriers and facilitate fast adsorption of CO, it is necessary to apply catalysts as a promoter. In this study, single-atom iron is introduced as the catalyst to reduce the energy barriers of CO adsorbed on pure/doped h-BN.

CO adsorption enhancement over Al/C-doped h-BN: A DFT study.

Reducing energy barriers of CO being chemisorbed on hexagonal boron nitride (h-BN) is a kernel step to efficiently and massively capture CO. In this study, aluminum/carbon (Al/C) atoms are used as dopants to alter surface potential fields of h-BN, which aims at lowering energy barriers of adsorption processes. Through theoretical calculations, direct-adsorption structures/properties of CO, joint-adsorption structures/properties of CO/HO, transition state (TS) energy barriers, effects of temperatures on adsorption energies/TS energy barriers and changes of reaction rate constants over different adsorbents are investigated in detail in order to reveal how doping of Al/C atoms promotes CO adsorption strength over doped h-BN.

Arsenic adsorption enhancement performances of Mn-modified γ-AlO with flue gas constituents involved.

Some flue gas constituents have negative effects on AsO adsorption of γ-AlO so promoting arsenic adsorption performances under complicated flue gas conditions is necessary based on previous studies. In this study, γ-AlO is modified with manganous nitrate and then Mn-modified γ-AlO is used as the adsorbents in experiments. Besides, molecular dynamics (MD) simulations and density functional theory (DFT) calculations are performed to explore mechanisms of how loadings of Mn enhance arsenic adsorption features of γ-AlO when being affected by flue gas constituents in microscale and mesoscale, respectively.

The distribution and conversion of selenite and selenate with the bubbling of simulated flue gas in simulated WFGD slurry.

Selenium is one of the hazardous trace elements emitted from coal-fired power plants. The distribution of selenium in Wet Flue Gas Desulfurization (WFGD) process is still unclear and even in controversial, impeding the development of selenium removal technologies. This research has found that the selenite in simulated slurry could be reduced by SO while selenate has not been affected.

What Is the Readiness Potential?

The readiness potential (RP), a slow buildup of electrical potential recorded at the scalp using electroencephalography, has been associated with neural activity involved in movement preparation. It became famous thanks to Benjamin Libet (Brain 1983;106:623-642), who used the time difference between the RP and self-reported time of conscious intention to move to argue that we lack free will. The RP's informativeness about self-generated action and derivatively about free will has prompted continued research on this neural phenomenon.

MicroRNA-1301-3p promotes the progression of non-small cell lung cancer by targeting Thy-1 and predicts poor prognosis of patients.

The role of microRNA (miR)-1301-3p has been investigated in breast cancer and colorectal cancer. Dysregulation of miR-1301-3p expression in non-small cell lung cancer (NSCLC) is speculated to be associated with tumor progression, which was systemically investigated in the present study. Reverse transcription-quantitative PCR analysis was performed to detect miR-1301-3p expression in 124 paired tissue samples and cultured cell lines.

Effects of O, SO, HO and CO on AsO adsorption by γ-AlO based on DFT analysis.

In order to reveal the affecting mechanisms of flue gas on AsO adsorption by γ-AlO and to enhance the adsorbing capacities of γ-AlO, the influences of flue gas constituents on AsO adsorption on γ-AlO(0 0 1) surface are investigated theoretically via density functional theory (DFT) in this study. The flue gas constituents selected include O, HO, SO and CO. O converts nearly all of the physisorption structures into chemisorption structures except one structure, in which the O electron cloud does not interact with AsO molecule and therefore does not enhance the capture of AsO.

Research on the removal of AsO by γ-AlO adsorption based on density functional theory.

In order to protect selective catalytic reduction (SCR) catalysts for flue gas denitration in coal-fired power plants, the adsorption of AsO on γ-AlO(0 0 1) surface is investigated theoretically through density functional theory (DFT) in this study. The adsorption sites, adsorption structures, adsorption energies, electronic clouds, transition processes, and intermediate and transition structures are investigated. The theoretical results indicate that the adsorption of AsO molecule on the surface of γ-AlO(0 0 1) could be either physical or chemical, depending on the sites the molecule hangs over.

Lamina feedback neurons regulate the bandpass property of the flicker-induced orientation response in Drosophila.

Natural scenes contain complex visual cues with specific features, including color, motion, flicker, and position. It is critical to understand how different visual features are processed at the early stages of visual perception to elicit appropriate cellular responses, and even behavioral output. Here, we studied the visual orientation response induced by flickering stripes in a novel behavioral paradigm in Drosophila melanogaster.

Differentiation of Theta Visual Motion from Fourier Motion Requires LC16 and R18C12 Neurons in Drosophila.

Many animals perceive features of higher-order visual motion that are beyond the spatiotemporal correlations of luminance defined in first-order motion. Although the neural mechanisms of first-order motion detection have become understood in recent years, those underlying higher-order motion perception remain unclear. Here, we established a paradigm to assess the detection of theta motion-a type of higher-order motion-in freely walking Drosophila.