Publications by authors named "PengFei Hu"

Water availability in built environment, including heritage, plays a fundamental role in microbial colonization and subsequent biodeterioration. However, it is uncertain about the relationship between specific water characteristics and microbial development. Here, we applied water intrusion gravimetry (WIG) to quantify water distribution and then linked it to microbial growth by combining molecular biology techniques and petrophysical and mineralogical analyses.

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Covering: 2019 to 2024Secondary metabolites (SMs) are naturally occurring defense or signaling molecules that are also utilized as human and animal drugs, crop protection agents, and fine chemicals. Currently, SMs are primarily produced in monoculture settings, devoid of the intricate microbial interactions found in natural environments. Monoculture may lead to the silencing of gene clusters, requiring various genetic or bioprocess strategies to activate the biosynthesis of the corresponding metabolites.

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Nitrogen (N)-transferring microorganisms can exacerbate biodegradation of world cultural heritage. This forum article focuses on microorganisms with ammonia-oxidizing and related reactions, newly detected on stone monuments, with an emphasis on their ecological diversity, acid production, and mechanisms of biodeterioration. This analysis provides a new research framework for understanding biodeterioration and future conservation management.

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The structural disorder of the black butterfly assists in capturing sunlight across a wider spectral and angular range, injecting infinite vitality for omnidirectional and stimuli-responsive wave-absorbing materials. Here, the disordered micro-pores responding to terahertz (THz) waves through electromagnetic simulations, and then prepared via ice templating technology are analyzed and optimized. The customized disordered aerogel makes possible perfect terahertz response property with incidence-angle-insensitive and ultra-broadband.

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In recent years, unmanned aerial vehicle (UAV) technology has advanced significantly, enabling its widespread use in critical applications such as surveillance, search and rescue, and environmental monitoring. However, planning reliable, safe, and economical paths for UAVs in real-world environments remains a significant challenge. In this paper, we propose a multi-strategy improved red-tailed hawk (IRTH) algorithm for UAV path planning in real environments.

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Deer antler-derived reserve mesenchyme cells (RMCs) are a promising source of cells for cartilage regeneration therapy due to their chondrogenic differentiation potential. However, the regulatory mechanism has not yet been elucidated. In this study, we analyzed the role of microRNAs (miRNAs) in regulating the differentiation of RMCs and in the post-transcriptional regulation of chondrogenesis and hypertrophic differentiation at the molecular and histological levels.

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Objective: To analyze the early- to mid-term clinical efficacy of personalized 3D-printed structural metal spacer technology in reconstructing massive bone defects during complex total knee arthroplasty (TKA) and revision surgery.

Methods: A single-center retrospective study was conducted on nine patients with severe bone defects who underwent TKA between 2018 and 2024. The general condition, surgical details, and clinical improvement of these patients were recorded and analyzed by clinical doctors.

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Human adenovirus (HAdV) is a widely spread respiratory pathogen that can cause infections in multiple tissues and organs. Previous studies have established an association between HAdV species B (HAdV-B) infection and severe community-acquired pneumonia (SCAP). However, the connection between SCAP-associated HAdV-B infection and host factor expression profile in patients has not been systematically investigated.

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Ovarian development is a complex process involving multiple genes, but the molecular mechanisms underlying this process in Takifugu rubripes remain poorly understood. This study aimed to identify genes associated with ovarian development in T. rubripes and to investigate the regulatory mechanisms of oocyte maturation.

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By manipulating their asymmetric electronic spin states, the unique electronic structures and unsaturated coordination environments of single atoms can be effectively harnessed to control their magnetic properties. In this research, the first investigation is presented into the regulation of magnetic properties through the electronic spin states of single atoms. Magnetic single-atom one-dimensional materials, M-N-C/ZrO (M = Fe, Co, Ni), with varying electronic spin states, are design and synthesize based on the electronic orbital structure model.

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Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive diseases and has remarkably high mortality rates. In recent years, altered metabolism has been shown to contribute to the maintenance of pancreatic cancer malignancies. However, the molecular mechanism underlying glucose metabolism reprogramming remains elusive.

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The molecular regulation mechanisms for maintaining the homeostasis of mesenchymal stem cells still remains poorly defined. Antler reserve mesenchymal cells (RM cells) persist through the whole rapid antler growth stage as a reserved stem cell population capable of division and differentiation, that makes the RM cells a unique model in stem cell regulation and cancer mechanism studies. Herein, we sequenced and analyzed the extracellular vesicles (EVs) of RM cells in the growth center of antler, and identified a high expression level of miR-143-3p and its target genes IGF1R, TGFβ1, BMP2, etc.

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As a global focus of animal husbandry, pigs provide essential meat resources for humans. Therefore, analyzing the genetic basis of adaptability, domestication, and artificial selection in pigs will contribute to further breeding. This study performed a genome-wide selection sweep analysis to identify candidate genes related to domestication and adaptive selection via data from 2413 public genotypes.

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The reconstruction of damaged neural circuits is critical for neurological repair after brain injury. Classical brain-computer interfaces (BCIs) allow direct communication between the brain and external controllers to compensate for lost functions. Importantly, there is increasing potential for generalized BCIs to input information into the brains to restore damage, but their effectiveness is limited when a large injured cavity is caused.

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Article Synopsis
  • Researchers developed Co-MoC nanoparticles within nitrogen-doped carbon nanofibers, showcasing a unique bamboo-like structure to tackle the challenges in efficient electrocatalysts for hydrogen evolution reactions (HER) and water splitting across different pH levels.
  • The combination of ultra-small MoC particles (≈5 nm) and cobalt (Co) optimizes the catalyst's electronic structure and enhances its electrocatalytic performance, achieving low overpotentials (86, 116, and 145 mV) for significant current density in alkaline, acidic, and neutral conditions.
  • The study highlights the potential of these Co-MoC/NCNFs in energy conversion applications, with a low required cell voltage of 1.59
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Neural crest cells (NCCs) are central to vertebrate embryonic development, giving rise to diverse cell types with unique migratory and differentiation capacities. This study examines the molecular characteristics of cranial neural crest cell (CNCC)-derived mesenchymal cells, specifically those from teeth which in deer show continuous but limited growth, and antlers, which exhibit remarkable regenerative capabilities. Here, through single-cell RNA sequencing analysis, we uncover shared gene expression profiles between adult antlerogenic and dental mesenchymal cells, indicating common developmental pathways.

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Article Synopsis
  • Scientists studied how tiny living things (microbes) break down old stone structures around the world.
  • They found that different climates, like dry or humid, affect which types of bacteria are present on these stones.
  • Some microbes help convert chemicals, like ammonia and sulfur, which plays a big role in protecting and breaking down these ancient stones.
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Optimizing the reactivity and selectivity of single-atom catalysts (SACs) remains a crucial yet challenging issue in heterogeneous catalysis. This study demonstrates selective catalysis facilitated by a polyoxometalates-mediated electronic interaction (PMEI) in a Pt single-atom catalyst supported on CeO modified with Keggin-type phosphotungstate acid (HPW), labeled as Pt/CeO-HPW. The PMEI effect originates from the unique arrangement of isolated Pt atoms and HPW clusters on the CeO support.

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Monoatomic-layered carbon materials, such as graphene and amorphous monolayer carbon, have stimulated intense fundamental and applied research owing to their unprecedented physical properties and a wide range of promising applications. So far, such materials have mainly been produced by chemical vapour deposition, which typically requires stringent reaction conditions compared to solution-phase synthesis. Herein, we demonstrate the solution preparation of free-standing nitrogen-doped amorphous monolayer carbon with mixed five-, six- and seven-membered (5-6-7-membered) rings through the polymerization of pyrrole within the confined interlayer cavity of a removable layered-double-hydroxide template.

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Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome with various phenotypes, and obesity is one of the most common and clinically relevant phenotypes of HFpEF. Obesity contributes to HFpEF through multiple mechanisms, including sodium retention, neurohormonal dysregulation, altered energy substrate metabolism, expansion of visceral adipose tissue, and low-grade systemic inflammation. Glucagon-like peptide-1 (GLP-1) is a hormone in the incretin family.

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The effect of crevice size on the crevice corrosion of N80 carbon steel was investigated by electrochemical measurements and surface analysis in a CO-saturated NaCl-HAc solution. The N80 carbon steel exhibits a high susceptibility to crevice corrosion in this environment, which can be initiated immediately without an induction period for specimens with crevice sizes of 100 μm, 300 μm, and 500 μm. Typically, crevice solutions become more acidic during crevice corrosion; however, in this study, the crevice solution became alkaline, resulting in galvanic corrosion between the inner and outer steel surfaces and leading to severe crevice corrosion.

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Nitrite-oxidizing bacteria (NOB) are undesirable in the anaerobic ammonium oxidation (anammox)-driven nitrogen removal technologies in the modern wastewater treatment plants (WWTPs). Diverse strategies have been developed to suppress NOB based on their physiological properties that we have understood. But our knowledge of the diversity and mechanisms employed by NOB for survival in the modern WWTPs remains limited.

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Article Synopsis
  • Microbial metabolism in landfill leachate is key to breaking down organic pollutants like bisphenol A (BPA), though research on BPA degradation in these environments is limited.
  • A global study found high levels of BPA in landfill leachates and identified major BPA-degrading bacteria such as Proteobacteria, Firmicutes, and Bacteroidota across 113 sites.
  • The study highlights that these BPA degraders work together with other bacteria to also manage nitrogen and sulfur removal and methane breakdown, suggesting complex interactions that could inform future research on BPA and microbial communities in various environments.
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Litter size is a key indicator of production performance in livestock. However, its genetic basis in goats remains poorly understood. In this work, a genome-wide selection sweep analysis (GWSA) on 100 published goat genomes with different litter rates was performed for the first time to identify candidate genes related to kidding rate.

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