Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis.

The necrosis of pancreatic acinar cells is a key molecular event in the progression of acute pancreatitis (AP), with disturbances in mitochondrial energy metabolism considered to be a direct causative factor of acinar cell necrosis. Histidine triad nucleotide-binding protein 2 (HINT2) has been implicated in the development of various diseases, whereas its involvement in the progression of AP remains unclear. This study aims to investigate the role of HINT2 in AP.

Multisite synergistic interaction induced selective adsorption of CB5-TiCT complex for strontium ion: A combined theoretical and experimental study.

In this work, we use a well-defined water-soluble macrocyclic molecule cucurbit[5]uril (CB5) to modify 2D TiCT MXene and assemble a novel high-performance adsorbent CB5-TiCT for Sr ion by density functional theory and experimental methods. The structural stabilities of two distinct types of CB5-TiCT (T = F, O and OH) complexes, i.e.

PbS@NiFe-LDH heterojunction: an efficient photo-assisted electrocatalyst for the OER.

Recently, photo-assisted electrocatalysis as an emerging catalytic approach that combines the technologies of photocatalysis and electrocatalysis has attracted great interest among researchers. Under this circumstance, the NiFe-LDH compounded with PbS based (PbS@NFHS) heterojunction with both photoactive and electrocatalytic properties was constructed for the first time through an ambient etching route and a subsequent low-temperature hydrothermal method. The as-prepared catalyst displayed a novel hierarchical 3D open structure based on nanosheets, which offered numerous electrochemically active sites, facilitated the swift diffusion of ions and enhanced both electrical conductivity and catalytic stability, thus significantly improving the catalytic performance.

Effects of pesticide dichlorvos on liver injury in rats and related toxicity mechanisms.

Dichlorvos (DDVP) is an organophosphorus pesticide commonly utilized in agricultural production. Recent epidemiological studies suggest that exposure to DDVP correlates with an increased incidence of liver disease. However, data regarding the hepatotoxicity of DDVP remain limited.

Environmental and Clinical Factors Concerning Gastrointestinal Bleeding: An Umbrella Review of Meta-Analyses.

Objectives: Gastrointestinal bleeding, an emergency and critical disease, is affected by multiple factors. This study aims to systematically summarize and appraise various factors associated with gastrointestinal bleeding.

Design: Umbrella review.

Injectable supramolecular hydrogel co-loading abemaciclib/NLG919 for neoadjuvant immunotherapy of triple-negative breast cancer.

The efficacy of cancer immunotherapy relies on a sufficient amount of functional immune cells. Triple-negative breast cancer lacks enough immune cell infiltration, and adjuvant therapy is necessary to prime anti-tumor immunity. However, the improvement in efficacy is unsatisfactory with concern about inducing systemic immunotoxicity.

Network Toxicology and Molecular Docking Analysis of Tetracycline-Induced Acute Pancreatitis: Unveiling Core Mechanisms and Targets.

Acute pancreatitis (AP), induced by tetracycline, a widely used antibiotic, poses significant clinical and toxicological challenges, yet its molecular mechanisms remain unclear. This study aims to promote drug toxicology strategies for the effective investigation of the putative toxicity and potential molecular mechanisms of antibiotic drugs through the study of tetracycline in AP. Using the SwissTargetPrediction, SEA Search, Super-PRED, GeneCards, Drugbank, Online Mendelian Inheritance in Man (OMIM), and Therapeutic Target Database (TTD), we identified 259 potential targets associated with tetracycline exposure and AP.

Comparative study of single-port single-channel and single-port multi-channel adrenalectomy in various maximum tumor diameters.

Background: Investigating the application of single-port single-channel and single-port multi-channel adrenalectomy in various maximum tumor diameters.

Methods: Retrospective analysis of clinical data from 218 adrenal tumors treated with single-port retroperitoneoscopic adrenalectomy at Lianyungang Clinical Medical College of Nanjing Medical University from September 2018 to November 2023. All adrenal tumors are benign lesions classified as T1 stage.

Predictive value of serum neurofilament light chain for cognitive impairment in Parkinson's disease.

Background: Neurofilament light chain (NfL) has recently emerged as a key indicator of neurodegeneration. In this study, our hypothesis is that the levels of blood-derived NfL and its accumulation during the Parkinson's disease (PD) progression could serve as a potential biomarker for predicting subsequent cognitive decline. To investigate this, we conducted a study utilizing a large single-center cohort.

Influencing factors of ocular pain in dry eye disease patients at high altitude.

Aim: To quantify the severity and frequency of ocular pain in Tibetan plateau patients with dry eye, and to evaluate the related factors affecting ocular pain.

Methods: A retrospective study included 160 cases of dry eye disease (DED) patients who were treated from July 2022 to June 2023. Age, gender, occupation, illness course, anxiety, plateau duration, plateau protection, ocular surface disease index scale (OSDI), break-up time (BUT), Schirmer I test (SIT), conjunctivitis, history of ophthalmic medication, autoimmune disease, the workload of daily near vision range, smoking and overnight stay were obtained comprehensive ophthalmic assessment, and their duration was followed up.

Coumarin-based fluorescent probes for the detection of copper (II) and imaging in mice of Wilson's disease.

Copper is an essential redox-active metal nutrient, with tightly regulated homeostasis. Copper homeostasis is closely linked to various diseases, making it a critical area of study. Fluorescent probes serve as powerful tools for investigating these conditions.

Prediction of ADN/ANF cocrystal and its theoretical properties.

Context: Ammonium dinitramide (ADN) is highly hygroscopic, which poses significant challenges in its practical applications. Consequently, mitigating this hygroscopic nature has been a primary focus in the research and development of ADN. This study investigated the properties of the ADN/3-amino-4-nitrofurazan (ANF) cocrystal using density functional theory, molecular dynamics, and Monte Carlo methods.

Naked-eye and fluorescence resonance energy transfer based ratiometric fluorescent probe for rapid, sensitive and selective detection of hydrazine and its applications in imaging of environmental samples and living systems.

Hydrazine, a compound recognized for its carcinogenic and genotoxic properties, presents a significant threat to human health via environmental exposure and drug metabolism. The detection of hydrazine is essential for safeguarding human health. However, a tool capable of accurately detecting hydrazine across diverse sample types, such as soil, water sources, and plant specimens contaminated by hydrazine leakage, as well as cells and live mice containing endogenously generated hydrazine from drug metabolism, is still lacking.

Interleukin 15-Presenting Nanovesicles with Doxorubicin-Loaded Ferritin Cores for Cancer Immunochemotherapy.

Interleukin 15 (IL15) is crucial for fostering the survival and proliferation of nature killer (NK) cells and cytotoxic T lymphocytes (CTLs), playing a pivotal role in tumor control. However, IL15 supplementary therapy encounters challenges such as systemic inflammation and non-specific stimulation of cancer cells. Herein, a nanovesicle termed DoxFILN, comprising a membrane presenting IL15/IL15 receptor α complexes (IL15c) and a core of doxorubicin-loaded ferritin (Dox-Fn) are reported.

Conformation Influences Biological Fates of Peptide-Based Nanofilaments by Modulating Protein Adsorption and Interfilament Entanglement.

Filamentous structures exert biological functions mediated by multivalent interactions with their counterparts in sharp contrast with spherical ones. The physicochemical properties and unique behaviors of nanofilaments that are associated with multivalent interaction with protein are poorly understood. Here, peptide-based nanofilaments containing different homotetrapeptidic inserts are reported and their protein adsorption and biological fates are tested.

Mussel-inspired oxidized sodium alginate/cellulose composite sponge with excellent shape recovery and antibacterial properties for the efficient control of non-compressible hemorrhage.

Enhancing the hemostatic efficacy and minimizing blood loss in the body has consistently been a primary objective for researchers. This study improved the hemostatic efficacy and tissue adhesion strength of the hemostatic material by augmenting the aldehyde groups in the side chains of sodium alginate. Additionally, it immobilized the aldehyde-modified sodium alginate onto the surface of the hemostatic material through complexation with iron ions, thereby enhancing its antibacterial properties.

Mechanism of traditional drug treatment of cancer-related ascites: through the regulation of IL-6/JAK-STAT3 pathway.

Context: Our clinical observation found that JiJiaoLiHuang Pill (JJLH), a classic traditional Chinese medicine (TCM) formulation, can significantly reduce the abdominal circumference of patients with malignant ascites, increase urine output, and improve the quality of life of patients, with preliminary efficacy. But, the exact mechanism is not yet clear.

Objective: Based on the above observations, the potential mechanism of action of the treatment was preliminarily explored.

In situ phase engineering during additive manufacturing enables high-performance soft-magnetic medium-entropy alloys.

Additive manufacturing (AM) shows promise as a method for producing soft-magnetic multicomponent alloys for use in electric motors and sustainable electromobility applications. However, the simultaneous achievement of a high saturation magnetic flux density (B) and a low coercivity (H) in AM soft-magnetic materials remains challenging. Herein, we present an approach that integrates an elemental powder mixture of FeCoNi with FeO nano-oxides, which is then subjected to laser powder bed fusion (LPBF) followed by high-temperature annealing to achieve an FCC-structured FeCoNi MEA/FeO composite.

Synthetic promoter design in based on multinomial diffusion model.

Generative design of promoters has enhanced the efficiency of creation of functional sequences. Though several deep generative models have been employed in biological sequence generation, including variational autoencoder (VAE) or Wasserstein generative adversarial network (WGAN), these models might struggle with mode collapse and low sample diversity. In this study, we introduce the multinomial diffusion model (MDM) for promoter sequence design and propose a structured set of criteria for effectively comparing the performance of generative models.

Engineered manganese-BODIPY coordinated nanoadjuvants for enhanced NIR-II photo-metalloimmunotherapy.

Immunotherapy, a pivotal and promising approach for tumor treatment, has demonstrated prominent clinical efficacy. However, its effectiveness is often impeded by insufficient antitumor immune responses attributed to the immunosuppressive tumor microenvironment (TME). The combination of immune activation through the stimulator of interferon genes (STING) pathway and phototherapy holds great potential for surmounting this challenge in advanced tumor immunotherapy.

Combination of edge enhancement and cold diffusion model for low dose CT image denoising.

Objectives: Since the quality of low dose CT (LDCT) images is often severely affected by noise and artifacts, it is very important to maintain high quality CT images while effectively reducing the radiation dose.

Methods: In recent years, the representation of diffusion models to produce high quality images and stable trainability has attracted wide attention. With the extension of the cold diffusion model to the classical diffusion model, its application has greater flexibility.

Causal relationships between epilepsy and the microstructure of the white matter: A Mendelian randomization study.

To examine the causal bidirectional relationships between epilepsy and microstructural changes in the white matter (WM). A genome-wide association study meta-analysis of the International League Against Epilepsy Consortium on Epilepsy and 360 WM imaging-derived phenotypes (IDPs) from the UK Biobank was used for the analysis. Genetic correlation analyses were conducted based on summary statistics of various "IDP-epilepsy" pairs for 2-sample Mendelian randomization (MR) analysis to explore the causal relationships.

Mobile stroke units based on rural emergency medical stations for pre-hospital intravenous thrombolysis of stroke in remote areas.

Objectives: To explore a novel model of mobile stroke units (MSUs) integrated with rural emergency medical stations for pre-hospital care of stroke patients in remote areas.

Methods: We used MSUs + Ambulance mode, where both the MSUs and conventional ambulances are sent to the patient's location. The conventional ambulance coordinates with the MSUs to choose the fastest route to meet and transfer the patient at the point along the way.

The MON1-CCZ1 complex plays dual roles in autophagic degradation and vacuolar protein transport in rice.

Autophagy is a highly conserved cellular program in eukaryotic cells which mediates the degradation of cytoplasmic components through the lysosome, also named the vacuole in plants. However, the molecular mechanisms underlying the fusion of autophagosomes with the vacuole remain unclear. Here, we report the functional characterization of a rice (Oryza sativa) mutant with defects in storage protein transport in endosperm cells and accumulation of numerous autophagosomes in root cells.