Publications by authors named "Peng-jun Su"
Background And Aims: Natural killer (NK) cells play an important role in biliary atresia (BA) pathogenesis; human poliovirus receptor (PVR) is an important NK-cell modulator. Here, we explored the role of PVR in BA pathogenesis.
Methods: Poliovirus receptor expression and NK cell-associated genes were detected in human BA samples and a rotavirus-induced BA mouse model using quantitative PCR and immunofluorescence staining.
Background: Constipation is one of the most common chronic digestive complaints. Gastrointestinal transit studies have divided it into three patterns: normal transit, slow transit constipation (STC), and outlet obstruction. It has been demonstrated that STC patients respond poorly to standard therapies, and the etiology of STC remains poorly understood.
View Article and Find Full Text PDFObjective: Functional constipation (FC) is a common complaint in childhood but the prevalence still remains unclear, the aim of this study was to explore the prevalence of FC in childhood in the northern parts of China.
Methods: A screening program on FC in childhood was carried out in 5 northern cities (Beijing, Tianjin, Shenyang, Changchun, Harbin) of China according to symptoms under the Rome III criteria. Random clustered sampling of the inhabitants was carried out under stratification of cities, geographic zones, schools or nurseries.
[Preliminary study on diagnostic standard of functional constipation in children from five cities in North China].
Zhonghua Wei Chang Wai Ke Za Zhi
September 2010
Article Synopsis
- The study aimed to identify diagnostic criteria for functional constipation (FC) in children aged 4-14 in five northern cities of China using the Rome III guidelines.
- Researchers distributed nearly 20,000 questionnaires to assess symptoms, resulting in 19,638 responses and further examinations for those who met FC criteria to rule out other conditions.
- Key findings revealed 18 symptoms linked to FC with statistically significant differences compared to a control group, highlighting factors like infrequent bowel movements and hard stools as strong indicators for diagnosis.
Objective: To quantitatively observe the sensory neurons innervating the levator ani muscle and explore the cause of poor post-operative anorectal function in patients with anorectal malformation (ARM).
Methods: Combining the microsurgery and microinjection techniques, we investigated the deficiency of sensory neurons of the spinal cord in fetal rats with anorectal malformation by injecting the retrograde tracer fluorogold (FG) into the muscle levator ani. Sixty 11 days pregnant female rats were fed with ethylenethiourea (ETU) so as to cause ARM in the fetuses.