A Bicyclic Dioxetane Chemiluminescence Nanoprobe for Peroxynitrite Imaging in Vivo.

Peroxynitrite (ONOO) is a critical biomarker associated with a wide array of diseases including cancer, inflammatory conditions, and neurodegenerative disorders. This study introduces an innovative chemiluminescence nanoprobe (CLNP) based on a bicyclic dioxetane structure, designed for highly sensitive and specific in vivo imaging of ONOO. Our CLNP demonstrates exceptional capabilities in generating high-contrast imaging of disease lesions, with applications verified across tumor models, acute inflammation, and acute liver injury scenarios.

A lysosome-targeting rhodamine fluorescent probe for Cu detection and its applications in test kits and zebrafish imaging.

Tracing copper ions levels in the environment and subcellular microenvironment is crucial due to the key role copper ions play in physiological and pathological processes. Herein, a novel naphthalimide-fused rhodamine probe Rh-Naph-Cu was prepared through modification with phenylhydrazine to produce a closed and non-fluorescent spirolactam. Based on the copper-induced spirolactam ring-opening and hydrolysis process, Rh-Naph-Cu can be employed as a fluorescence off-on probe for copper ions with high selectivity, high sensitivity (limit of detection: 33.

The novel HLA-A*02:1146 allele, identified by Sanger dideoxy nucleotide sequencing in a Chinese individual.

HLA-A*02:1146 differs from HLA-A*02:01:01:01 by one nucleotide in exon 1.

Fifteen acute retrobulbar optic neuritis associated with COVID-19: A case report and review of literature.

Background: A subtype of the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is suggested to be responsible for the outbreak in Northern China since the quarantine was lifted in December 2022. The coronavirus disease 2019 virus is primarily responsible for the development of respiratory illnesses, however, it can present a plethora of symptoms affecting a myriad of body organs. This virus has been theorized to be linked to demyelinating lesions of the peripheral and central nervous system including transverse myelitis and acute retrobulbar optic neuritis (ARON).

Simulation-Assisted DNA Nanodevice Serve as a General Optical Platform for Multiplexed Analysis of Micrornas.

Small frame nucleic acids (FNAs) serve as excellent carrier materials for various functional nucleic acid molecules, showcasing extensive potential applications in biomedicine development. The carrier module and function module combination is crucial for probe design, where an improper combination can significantly impede the functionality of sensing platforms. This study explores the effect of various combinations on the sensing performance of nanodevices through simulations and experimental approaches.

Acute Mesenteric Ischemia in Patients with COVID-19: Review of the literature.

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a global health emergency. In addition to common respiratory symptoms, some patients with COVID-19 infections may experience a range of extra-pulmonary manifestations, such as digestive system involvement. Patients with COVID-19 have been reported to suffer from acute mesenteric ischemia (AMI) that is associated with disease-related severity and mortality.

A lateral flow dipstick combined with reverse transcription recombinase polymerase amplification for rapid and visual detection of the BVDV and BPIV3.

Bovine respiratory disease complex (BRDC) is a serious disease affecting feedlot cattle in China and likely other places worldwide. Bovine viral diarrhea virus (BVDV) and bovine parainfluenza virus type 3 (BPIV3) are principally responsible for causing BRDC, and are a major strain to the industrial economy. Eradication of these viruses/disease requires swift viral identification and treatment.

[Polycyclic Aromatic Hydrocarbons in Surface Soil of China (2000-2020): Temporal and Spatial Distribution, Influencing Factors].

With the rapid development of China's economy and society, the polycyclic aromatic hydrocarbon (PAH) pollution of surface soil has attracted increasing attention. Based on a systematic review, this study identified 166 relevant papers (published from 2000 to 2020) dealing with the contamination of 16 PAHs in the surface soil of China and summarized the pollution level, temporal, and spatial distribution influencing factors of PAHs with statistics, spatial interpolation analysis, and source analysis methods. The results showed that the surface soil of China has been polluted by human-caused PAHs, with a median concentration of 675.

Katanin P80 expression correlates with lymph node metastasis and worse overall survival in patients with breast cancer.

Objective: The aim of this study was to investigate the correlation of katanin P80 expression with clinicopathological features and overall survival (OS) in surgical breast cancer (BC) patients.

Methods: Four hundred and fourteen BC patients underwent surgery were analyzed in this retrospective cohort study. Katanin P80 expression was examined by immunofluorescence assay.

[Prognostic Value of Morphology and Hans Classification in Diffuse Large B Cell Lymphoma].

Objective: To investigate the prognostic value of morphology and Hans classification in diffuse large B cell lymphoma（DLBCL）.

Methods: Clinical data of 249 patients diagnosed with DLBCL in our hospital and Hangzhou Xixi hospital during Jan 2006 to Dec 2016 were analyzed retrospectively. These patients were classified into 3 groups: immunoblastic variant（IB） group, centroblastic variant（CB） group and others group according to the cell morphology.

[Nitrogen flow characteristic and use efficiency in mixed crop-livestock system in North China Plain: Hebei Jinlong Circular Agriculture Farm as an example].

Scale and intensive development of mixed crop-livestock agriculture is inevitable in North China Plain (NCP), and nitrogen (N) is one of the key elements that linked the crop and livestock production. Here, we used Hebei Jinlong Circular Agriculture Farm as an example, to analyze the N flow and use efficiency, by using data from literature, on-farm survey and modeling. Further, several on-farm N management improvement practices were proposed and evaluated through scenario analysis, to supply technical support and scientific basis not only for achieving higher N use efficiency and productivity at the farm level, but also providing a new model of circular agriculture in NCP.

Targeting of phospho-eIF4E by homoharringtonine eradicates a distinct subset of human acute myeloid leukemia.

More than half of the patients with acute myeloid leukemia (AML) fail to achieve long-term disease-free survival with current therapies and novel therapeutic strategies are urgently needed. The effects of homoharringtonine (HHT) on the growth of AML cell lines and primary leukemia cells were examined using MTT, colony formation assay. The effects of HHT on both eukaryotic translation initiation factor 4E (eIF4E) and phospho-eIF4E(p-eIF4E) were examined through western blot and immunofluorescence staining.

Several [Gd-M] Heterometal-Organic Frameworks with [Gd] as Nodes: Tunable Structures and Magnetocaloric Effect.

Tunable structures and magnetocaloric effect (MCE) of seven MOFs with [Gd] as nodes are explored. The [Gd] node is realized from mononuclear [Gd] to binuclear paddle-wheel [Gd], tetranuclear tetrahedral [Gd], and pentanuclear trigonal bipyramidal [Gd]. Meanwhile, the magnetic entropy changes from 19.

[Effect of long noncoding RNA SPRY4-IT1 on proliferation and metastasis of medulloblastoma].

Objective: To investigate the effects of long non-coding RNA SPRY4-IT1 (LncRNA) on proliferation and metastasis of medul-loblastoma cells.

Methods: SPRY4-IT1siRNA and control fluorescence siRNA were transfected into medulloblastoma cell line Daoy with Lipo-fe ctamine 2000 and were divided into control group and si-SPRY4-IT1 group. Relative expression of SPRY4-IT1 mRNA were detected by real-time quantitative PCR.

[Effect of matrine on cell apoptosis and proliferation and the apoptosis related proteins of human medulloblastoma D341 cells in vitro].

Objective: To investigate the apoptosis and proliferation effect of matrine on human medulloblastoma cell line D341 in vitro and the effect of the expression of the related caspase 3 and caspase 9 proteins.

Methods: The D341 cells were cultivated successfully in vitro. Then the cells were divided into 5 groups according to the concentration of matrine (0.

[The relationship between hypermethylation of Syk gene promoter and medulloblastoma cell invasion and metastasis].

Objective: To investigate the effect of demethylation of Syk gene promoter by the methylation transferase inhibitor 5-aza-CdR on the invasion and metastasis of medulloblastoma cell line Daoy.

Methods: Medulloblastoma cell line Daoy was treated with 5-aza-CdR Methylation-specific PCR, real time-PCR and Western blot were used to detect Syk gene promoter methylation status, Syk mRNA and protein expression respectively. Transwell was employed to study the invasion and metastasis of medulloblastoma cell line Daoyby counting the cells that had invaded through Matrigel and migrated to the undersurface of the membrane before and after treatment of 5-aza-CdR.

Ultrastrong Alkali-Resisting Lanthanide-Zeolites Assembled by [Ln60] Nanocages.

Zeolites, as one of the most important porous materials, are most widely utilized in sorbents, catalysis, and ion-exchange fields. However, the multi-functional lanthanide-zeolites constructed exclusively by lanthanide ions and oxygen linkers are to our knowledge unknown hitherto. Herein, we, for the first time, report the unique structure and multifunctions of lanthanide zeolites (1·Gd, 1·Tb, 1·Dy), featuring 60 nuclear [Ln60] nanocages as building blocks and ultrastrong alkali-resisting.

Heterometal-organic frameworks as highly sensitive and highly selective luminescent probes to detect I⁻ ions in aqueous solutions.

Two cationic heterometal-organic frameworks (Eu-Zn (1·NO₃⁻) and Tb-Zn (2·NO₃⁻)) with NO3(-) counter-anions in the channels are structurally and luminously characterized. Both of them can serve as highly sensitive and highly selective luminescent probes for detecting I(-) ions in aqueous solutions. In particular, 2·NO₃⁻ can selectively and reversibly detect I(-) with a fast response time of just 10 s and an extremely low detection limit of 0.

New strategy to construct single-ion magnets: a unique Dy@Zn₆ cluster exhibiting slow magnetic relaxation.

Two unique heptanuclear clusters Ln@Zn6 (Ln = Dy (1), Er (2)) were structurally and magnetically characterized. Each Dy(3+)/Er(3+) is located in a nona-coordinate D(3h) coordination environment, and is encapsulated in a diamagnetic Zn6 cage. Compound 1 exhibits single-ion magnetic behavior, and is the first example of a single-ion magnet (SIM) constructed through embedding one magnetic anisotropic metal ion into a diamagnetic cage.

Unique (3,12)-connected coordination polymers displaying high stability, large magnetocaloric effect and slow magnetic relaxation.

Two unique 3D coordination polymers based on octahedral [Ln6] (Ln = Gd (), Dy ()) clusters as nodes were synthesized, exhibiting a novel (3,12)-connected topology with the symbol of (4(20)·6(26)·8(20))(4(3))4. The magnetic studies reveal that shows a -ΔSm = 46.6 J kg(-1) K(-1), falling among the largest values known to date, and displays slow magnetic relaxation behavior.

Structures, luminescence, and slow magnetic relaxation of eight 3D lanthanide-organic frameworks.

Eight three-dimensional lanthanide-organic frameworks: [Ln(BPDC)1.5(DMF)(H2O)2]·2H2O (Ln = Eu (1), Gd (2), Tb (3), Dy (4); BPDC = 4,4'-dicarboxylate-2,2'-dipyridine anion), [Ln(BPDC)(DMF)2(NO3)] (Ln = Eu (5), Gd (6), Tb (7), Dy (8)) were fabricated and structurally characterized. Compounds 1-4 are isostructural, belonging to the triclinic system with space group P1¯, while compounds 6-8 belong to the monoclinic system with space group C2/c.

Anion-induced changes of structure interpenetration and magnetic properties in 3D Dy-Cu metal-organic frameworks.

Two novel Dy-Cu MOFs were structurally and magnetically characterized. The results reveal that it is the first example of anion-induced change of structure interpenetration and magnetic properties in 3d-4f MOFs.

Structural diversity and magnetic properties of five copper-organic frameworks containing one-, two-, and three-types of organic ligands.

Five novel compounds {[Cu(CMA)]·0.8H(2)O}(n) (1), {[Cu(CMA)(bpy)(0.5)]·0.

3 D MOFs containing trigonal bipyramidal Ln5 clusters as nodes: large magnetocaloric effect and slow magnetic relaxation behavior.

Two 3D heterometal-organic frameworks based on infrequent trigonal bipyramidal Ln(5)  clusters as nodes were structurally and magnetically characterized (Ln=Gd (1), Dy (2)). The results indicate large MCE of up to 30.7 J kg(-1)  K(-1) in 1 and slow magnetic relaxation behavior in 2.

Fast capture and separation of, and luminescent probe for, pollutant chromate using a multi-functional cationic heterometal-organic framework.

We present one 3D cationic MOF (1-ClO(4)), which exhibits high thermal stability and strong alkali resistance. More importantly, it displays fast, selective capture of, and acts as a luminescent probe for, pollutant CrO(4)(2-) by anion exchange. Additionally, 1-ClO(4) exhibits interesting slow magnetic relaxation behavior at low temperature.