Publications by authors named "Peng-Zhe Qin"

Background: Quantitative evidence on the impact of meteorological factors on influenza transmissibility across different virus types/subtypes is scarce, and no previous studies have reported the effect of hourly temperature variability (HTV) on influenza transmissibility. Herein, we explored the associations between meteorological factors and influenza transmissibility according to the influenza type and subtype in Guangzhou, a subtropical city in China.

Methods: We collected influenza surveillance and meteorological data of Guangzhou between October 2010 and December 2019.

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Article Synopsis
  • The study explores the relationship between megacity expansion and the gap between health-adjusted life expectancy (HALE) and overall life expectancy (LE) in Guangzhou, China.
  • Despite increases in both LE and HALE, the gap between them is widening, indicating a decline in quality of life.
  • Factors like personal wealth, population growth, urbanization, and healthy aging are crucial for narrowing this gap, suggesting that multiple social determinants should be considered in public health planning.
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Background: The first community transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant of concern (VOC) in Guangzhou, China occurred between May and June 2021. Herein, we describe the epidemiological characteristics of this outbreak and evaluate the implemented containment measures against this outbreak.

Methodology/principal Findings: Guangzhou Center for Disease Control and Prevention provided the data on SARS-CoV-2 infections reported between 21 May and 24 June 2021.

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The effectiveness of inactivated SARS-CoV-2 vaccines against the Delta variant, which has been associated with greater transmissibility and virulence, remains unclear. We conducted a test-negative case-control study to explore the vaccine effectiveness (VE) in real-world settings. We recruited participants aged 18-59 years who consisted of SARS-CoV-2 test-positive cases ( = 74) and test-negative controls ( = 292) during the outbreak of the Delta variant in May 2021 in Guangzhou city, China.

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Background: Studies related to the SARS-CoV-2 spikes in the past few months, while there are limited studies on the entire outbreak-suppressed cycle of COVID-19. We estimate the cause-specific excess mortality during the complete circle of COVID-19 outbreak in Guangzhou, China, stratified by sociodemographic status.

Methods: Guangzhou Center for Disease Control Prevention provided the individual data of deaths in Guangzhou from 1 January 2018 through 30 June 2020.

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Article Synopsis
  • China faced an initial peak and decline of COVID-19 cases in early 2020, leading to ongoing regional outbreaks and resurgences in other countries.
  • In Guangzhou, a small outbreak under 100 cases prompted extensive genomic surveillance, revealing diverse viral variants primarily transmitted within households rather than on flights.
  • Enhanced public health measures for overseas travelers, including mandatory testing and quarantine, were found effective in containing the virus's spread and highlighted the importance of genomic data for informing public health strategies.
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From 11 March to 6 July 2020, a total of 268 imported cases of COVID-19 from abroad were confirmed in Guangzhou. 74% of the imported cases were detected during customs inspection and 19% under centralized quarantine. We advocate for legally enforced quarantine and monitoring of quarantined persons.

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Objective: To find out the data sources of respiratory syndromes and their components from the outpatients of general hospitals and to describe the time distribution and mutual relations of different respiratory syndromes. Feasibility of respiratory syndromes used for early warning surveillance on respiratory infectious disease was also under research.

Methods: Retrospective investigation on Hospital Information System (HIS) was implemented in a general hospital in Guangzhou, 2005, and data of outpatients was collected and classified into different syndromes.

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  • A study in Guangzhou in 2006 investigated a human case of avian influenza to determine if it could be transmitted to close contacts.
  • The patient had no recent travel or contact with infected poultry, and 56 close contacts were monitored for 7 days without any signs of infection.
  • The findings suggest that, unlike SARS, avian influenza does not easily spread from human to human, indicating limited transmission potential.
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A patient may have been infected with highly pathogenic avian influenza virus H5N1 in Guangzhou, People's Republic of China, at a food market that had live birds. Virus genes were detected in 1 of 79 wire cages for birds at 9 markets. One of 110 persons in the poultry business at markets had neutralizing antibody against H5N1.

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An asymptomatic case of severe acute respiratory syndrome (SARS) occurred early in 2004, during a community outbreak of SARS in Guangzhou, China. This was the first time that a case of asymptomatic SARS was noted in an individual with antigenemia and seroconversion. The asymptomatic case patient and the second index case patient with SARS in the 2003-2004 outbreak both worked in the same restaurant, where they served palm civets, which were found to carry SARS-associated coronaviruses.

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The genomic sequences of severe acute respiratory syndrome coronaviruses from human and palm civet of the 2003/2004 outbreak in the city of Guangzhou, China, were nearly identical. Phylogenetic analysis suggested an independent viral invasion from animal to human in this new episode. Combining all existing data but excluding singletons, we identified 202 single-nucleotide variations.

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Objective: To analyze the epidemiological characteristics, related risk factors, measures for its control of severe acute respiratory syndrome (SARS).

Methods: Data on epidemiological features, pathogens and measures for control were collected and analyzed.

Results: Since Jan 2003, infectious atypical pneumonia (AP) has become epidemic in Guangzhou city.

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