iRNAD: a computational tool for identifying D modification sites in RNA sequence.

Motivation: Dihydrouridine (D) is a common RNA post-transcriptional modification found in eukaryotes, bacteria and a few archaea. The modification can promote the conformational flexibility of individual nucleotide bases. And its levels are increased in cancerous tissues.

Identifying Phage Virion Proteins by Using Two-Step Feature Selection Methods.

Accurate identification of phage virion protein is not only a key step for understanding the function of the phage virion protein but also helpful for further understanding the lysis mechanism of the bacterial cell. Since traditional experimental methods are time-consuming and costly for identifying phage virion proteins, it is extremely urgent to apply machine learning methods to accurately and efficiently identify phage virion proteins. In this work, a support vector machine (SVM) based method was proposed by mixing multiple sets of optimal g-gap dipeptide compositions.

PHYPred: a tool for identifying bacteriophage enzymes and hydrolases.

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iTIS-PseTNC: a sequence-based predictor for identifying translation initiation site in human genes using pseudo trinucleotide composition.

Translation is a key process for gene expression. Timely identification of the translation initiation site (TIS) is very important for conducting in-depth genome analysis. With the avalanche of genome sequences generated in the postgenomic age, it is highly desirable to develop automated methods for rapidly and effectively identifying TIS.

iSS-PseDNC: identifying splicing sites using pseudo dinucleotide composition.

In eukaryotic genes, exons are generally interrupted by introns. Accurately removing introns and joining exons together are essential processes in eukaryotic gene expression. With the avalanche of genome sequences generated in the postgenomic age, it is highly desired to develop automated methods for rapid and effective detection of splice sites that play important roles in gene structure annotation and even in RNA splicing.

Identification of bacteriophage virion proteins by the ANOVA feature selection and analysis.

The bacteriophage virion proteins play extremely important roles in the fate of host bacterial cells. Accurate identification of bacteriophage virion proteins is very important for understanding their functions and clarifying the lysis mechanism of bacterial cells. In this study, a new sequence-based method was developed to identify phage virion proteins.

Identification of antioxidants from sequence information using naïve Bayes.

Antioxidant proteins are substances that protect cells from the damage caused by free radicals. Accurate identification of new antioxidant proteins is important in understanding their roles in delaying aging. Therefore, it is highly desirable to develop computational methods to identify antioxidant proteins.

Naïve Bayes classifier with feature selection to identify phage virion proteins.

Knowledge about the protein composition of phage virions is a key step to understand the functions of phage virion proteins. However, the experimental method to identify virion proteins is time consuming and expensive. Thus, it is highly desirable to develop novel computational methods for phage virion protein identification.

iHSP-PseRAAAC: Identifying the heat shock protein families using pseudo reduced amino acid alphabet composition.

Heat shock proteins (HSPs) are a type of functionally related proteins present in all living organisms, both prokaryotes and eukaryotes. They play essential roles in protein-protein interactions such as folding and assisting in the establishment of proper protein conformation and prevention of unwanted protein aggregation. Their dysfunction may cause various life-threatening disorders, such as Parkinson's, Alzheimer's, and cardiovascular diseases.

iRSpot-PseDNC: identify recombination spots with pseudo dinucleotide composition.

Meiotic recombination is an important biological process. As a main driving force of evolution, recombination provides natural new combinations of genetic variations. Rather than randomly occurring across a genome, meiotic recombination takes place in some genomic regions (the so-called 'hotspots') with higher frequencies, and in the other regions (the so-called 'coldspots') with lower frequencies.

iNuc-PhysChem: a sequence-based predictor for identifying nucleosomes via physicochemical properties.

Nucleosome positioning has important roles in key cellular processes. Although intensive efforts have been made in this area, the rules defining nucleosome positioning is still elusive and debated. In this study, we carried out a systematic comparison among the profiles of twelve DNA physicochemical features between the nucleosomal and linker sequences in the Saccharomyces cerevisiae genome.