Publications by authors named "Peng-Ju Gong"

A growing amount of evidence has indicated immune genes perform a crucial position in the development and progression of breast cancer microenvironment. The purpose of our study was to identify immunogenic prognostic marker and explore potential regulatory mechanisms for breast cancer. We identified the genes related to ImmuneScore using ESTIMATE algorithm and WGCNA analysis, and we identified the differentially expressed gene (DEGs).

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Article Synopsis
  • - This study investigates the role of N6-methyladenosine (m6A) modifications in breast cancer, focusing on the expression levels of two specific methylation transferases, METTL14 and ZC3H13, which are found to be down-regulated in breast cancer instances.
  • - The low expression of METTL14 and ZC3H13 is linked to worse survival rates across various breast cancer subtypes and is correlated with specific cancer characteristics such as hormone receptor negativity and tumor grade progression.
  • - The research also highlights a positive relationship between the expression of METTL14, ZC3H13, and an anti-cancer factor (APC) as well as their involvement with immune cell infiltration
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Objective: Many primary tumors have insufficient supply of molecular oxygen, called hypoxia. Hypoxia is one of the leading characteristics of solid tumors resulting in a higher risk of local failure and distant metastasis. It is quite necessary to investigate the hypoxia associated molecular hallmarks in breast cancer.

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Gastric cancer (GC) is one of the most common malignant neoplasms of the digestive system, with China leading in terms of morbidity and mortality rates. Betulinic acid (BA) is a widely-occurring pentacyclic triterpenoid that has been reported to exhibit potent anti-inflammatory, antioxidant, and antitumor activities. BA can combat tumors by inducing apoptosis, regulating cell cycle, and inhibiting autophagy, but its mechanism of action in the context of GC is unclear.

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