Extraction, characterization, and biological activity in vitro of polysaccharides from discarded young fig fruits based on various extraction methods.

Discarded young fig fruits (DYFFs) are rich in polyphenols, polysaccharides, and other active substances, and fig polysaccharides (FPs) extracted from DYFFs using different methods vary in structure, processing characteristics, and biological activities, which are of great research value. The polysaccharides extracted from DYFFs using different extraction methods were used to compare the structures, processing characteristics, and biological activities of FPs, and to research the conformational relationships. The yield of MDP (6.

Homogeneously Distributed Heterostructure Energizes and Replenishes Oxygen Species for Boosting Toluene Oxidation on Perovskite Oxide Catalysts.

Enriching oxygen species in perovskite catalysts provides more active sites for the catalytic oxidation of air pollutants, but its further application in environmental chemical engineering is still constrained by the inherent lack of oxygen species reactivity and the difficulty of replenishing depleted oxygen species. Herein, we present a scalable one-pot strategy for the in situ fabrication of a homogeneously distributed heterostructure, which brings LaCuO perovskite a 58-fold activity enhancement and robust antisintering/water/coke in toluene oxidation, higher than currently reported perovskite catalysts. Superior to the single "oxygen enrichment" effect of conventional surface-aggregated heterostructures, the homogeneously distributed heterostructures induce the reactivity enhancement of adsorbed oxygen and the backfilling/replenishment of depleted lattice oxygen, which break through the rate-determining steps of the low-temperature Langmuir-Hinshelwood and the high-temperature Mars-van Krevelen mechanisms, respectively.

Regulation of alternative splicing by CBF-mediated protein condensation in plant response to cold stress.

Cold acclimation is critical for the survival of plants in temperate regions under low temperatures, and C-REPEAT BINDING FACTORs (CBFs) are well established as key transcriptional factors that regulate this adaptive process by controlling the expression of cold-responsive genes. Here we demonstrate that CBFs are involved in modulating alternative splicing during cold acclimation through their interaction with subunits of the spliceosome complex. Under cold stress, CBF proteins accumulate and directly interact with SKI-INTERACTING PROTEIN (SKIP), a key component of the spliceosome, which positively regulates acquired freezing tolerance.

Distribution and Antibiotic Resistance Analysis of 13,048 Clinically Common Isolates.

Objective: This study investigated the distribution and antibiotic resistance profiles of common bacteria isolated from clinical specimens at a hospital's microbiology laboratory between 2020 and 2022.

Methods: A retrospective analysis was conducted on microbial culture results from clinical specimens collected over three years, including sample types, departmental distribution, pathogen species, and resistance profiles.

Results: A total of 13,048 unique pathogenic strains were isolated, predominantly from respiratory and urine specimens.

ArgR-dependent bacterial resistance to host lipid droplets in Edwardsiella piscicida.

Lipid droplets (LDs), as innate immune hubs, function in the front line of antimicrobial defense involved in the host-pathogen arms race. Particularly for intracellular bacterial pathogens, the endowed capacity to resist host LDs can effectively facilitate pathogen in vivo colonization and evasion from the host's innate immune response. Here, to investigate the genetic mechanisms of intracellular bacteria response to host LDs, we utilized transposon insertion sequencing to dissect critical fitness determinants of Edwardsiella piscicida under the treatment of LDs isolated from its native host, turbot.

Clinical comparative study of the modified superior mesenteric artery approach in total laparoscopic radical resection for right colon cancer - a single-center retrospective study.

Background: To explore the safety and feasibility of the modified approach for accessing the superior mesenteric artery (SMA) in total laparoscopic radical resection for right colon cancer.

Methods: This single-center retrospective study included 107 patients who underwent total laparoscopic radical resection of right colon cancer at The First Affiliated Hospital of Wannan Medical College between August 2022 and December 2023. 53 patients were in the modified SMA approach (modified group) and 54 patients were in the traditional SMA approach (control group).

The effects and mechanisms of aqueous Persicaria capitata extract on uropathogenic Escherichia coli adhesion.

Background: Urinary tract infections (UTIs) in humans are common, with uropathogenic Escherichia coli (UPEC) being the primary pathogen. The adhesive capabilities of UPEC are a substantial pathogenicity factor. Due to limitations of first-line antibiotics, Persicaria capitata (Buch.

Lattice Oxygen Engineering on Perovskite Oxide Catalysts: Concurrent Enhancement of Reactivity and Replenishment for Volatile Organic Compounds Oxidation.

The catalytic volatile organic compound oxidation poses a dilemma for perovskite (ABO) catalysts, as their high lattice oxygen reactivity (electron-deficient O) depends on attracting coordinated oxygen electrons through an increased electronegativity of B-site cations, but this impedes the healing of oxygen vacancies and thus results in a low concentration of active lattice oxygen due to the limited O dissociation in electron-deficient environments. Herein, we compress [Co/MnO] octahedra through A-site Cs doping in the double perovskite (LaCoMnO), which optimizes the orbital hybridization between Co/Mn 3d and O 2p. This promotes electron transfer from O to Co/Mn while reducing Co/Mn electronegativity, resulting in a synergistic improvement of lattice oxygen reactivity and oxygen vacancy healing.

Hole-Mediated Lattice Oxygen Redox Design for Perovskite Oxide Catalysts.

Present design and application of perovskite oxide catalysts assume lattice oxygen redox (LOR) mechanisms that depend on lattice oxygen activity without consideration of the entire redox cycle. Herein, using in situ characterizations and theoretical calculations, we uncover a hole-mediated LOR cycle on p-type Sr-deficient SrFeO (SFO-Srv) perovskites in CO oxidation reaction. Sr vacancies activate surface lattice oxygen of SFO-Srv and promote formation of highly covalent Fe-O sites.

The utility and feasibility of three-dimensional reconstruction in surgical planning for multiple pulmonary nodules: a prospective self-controlled study.

Background: Three-dimensional (3D) is a useful tool for visualizing computed tomography (CT) scans, facilitating a clearer understanding of the spatial relationships between pulmonary lesions and the branching architecture of the bronchi and blood vessels. Several studies have demonstrated the benefit of preoperative 3D reconstruction in terms of intraoperative safety and short-term surgical outcomes after thoracoscopic surgery. However, evidence regarding the impact of 3D reconstruction on surgical planning of anatomical partial lobectomy (APL) is still lacking.

Functional connectivity changes in the prefrontal-thalamic-cerebellar circuit in adolescents with first-episode Schizophrenia.

Background: The role of functional connectivity (FC) changes in the prefrontal-thalamic-cerebellar circuit in schizophrenia has received widespread attention. Currently, domestic and international studies on this circuit have focused on adults, while the FC of this circuit in the brains of adolescent patients with schizophrenia (AOS) has been less reported.

Methods: We recruited 124 subjects who underwent resting-state functional magnetic resonance imaging scans at baseline, using key brain regions in the prefrontal-thalamic-cerebellar circuit as seed regions, to investigate the FC in AOS versus healthy controls.

Contrastive-learning of language embedding and biological features for cross modality encoding and effector prediction.

Identifying and characterizing virulence proteins secreted by Gram-negative bacteria are fundamental for deciphering microbial pathogenicity as well as aiding the development of therapeutic strategies. Effector predictors utilizing pre-trained protein language models (PLMs) have shown sound performance by leveraging extensive evolutionary and sequential protein features. However, the accuracy and sensitivity of effector prediction remain challenging.

Single-cell RNA sequencing reveals the intercellular crosstalk and the regulatory landscape of stromal cells during the whole life of the mouse ovary.

The heterogeneity of ovarian mesenchymal/stromal cells has just been revealed in both mice and humans. However, it remains unclear about the cellular development trace and the intercellular communication network in the whole life of the ovary. In the study, we integrated ours and published single-cell RNA sequencing data from E11.

Modulation of Co spin state at CoO crystalline-amorphous interfaces for CO oxidation and NO decomposition.

Modulation of electronic spin states in cobalt-based catalysts is an effective strategy for molecule activations. Crystalline-amorphous interfaces often exhibit unique catalytic properties due to disruptions of long-range order and alterations in electronic structure. However, the mechanisms of molecule activation and spin states at interfaces remain elusive.

A new selective mediastinal lymph node dissection for clinical peripheral stage IA invasive non-small-cell lung cancer: a propensity-score matching study.

Background: The optimal extent of lymph node resection for early-stage non-small cell lung cancer (NSCLC) remains a topic of debate in the medical community. We aimed to assess the surgical and prognostic outcomes based on the extent of mediastinal lymph node dissection (MLND) for resectable clinical stage IA NSCLC.

Methods: From 2016 to 2018, 1,166 patients with clinical stage IA NSCLC who underwent lobectomy or segmentectomy with complete mediastinal lymph node dissection (C-MLND) or selective mediastinal lymph node dissection (S-MLND) at five hospitals were enrolled.

Machine learning-based radiomics for guiding lymph node dissection in clinical stage I lung adenocarcinoma: a multicenter retrospective study.

Background: Preoperative assessment of lymph node status is critical in managing lung cancer, as it directly impacts the surgical approach and treatment planning. However, in clinical stage I lung adenocarcinoma (LUAD), determining lymph node metastasis (LNM) is often challenging due to the limited sensitivity of conventional imaging modalities, such as computed tomography (CT) and positron emission tomography/CT (PET/CT). This study aimed to establish an effective radiomics prediction model using multicenter data for early assessment of LNM risk in patients with clinical stage I LUAD.

Generalized Stokes polarimetry design for a 3-D polarization field.

Optical polarization is three-dimensional (3-D). Its complete information is described by the nine-component generalized Stokes vector (GSV). However, existing Stokes polarimetry and its design theory are primarily based on the paraxial four-component Stokes vector and 4 × 4 Mueller matrices.

[Comparative study on metabolites in rat liver microsomes, urine, feces and bile between Shuganning Injection and Scutellariae Radix extract].

This study aims to compare the metabolic differences of baicalin and its analogues between Shuganning Injection and Scutellariae Radix extract. Twelve SD rats were randomly divided into a Shuganning Injection group and a Scutellariae Radix extract group, with 6 rats in each group. Their liver microsomes were incubated with the drugs, and then the samples were collected.

Association of depressive symptoms and cardiovascular health with mortality among U.S. adults.

Background: Depression and cardiovascular health (CVH) are interconnected, and both are independently associated with mortality. However, the joint effects of depressive symptoms and CVH on mortality remain unclear.

Methods: By utilizing the National Health and Nutrition Examination Survey (NHANES) 2007-2018, we included 18,679 adults aged ≥20 years without cardiovascular diseases (CVD).

A Nomogram Model for Predicting Recurrent Coronary Thrombosis in Kawasaki Disease Patients.

Background: Coronary thrombosis is a serious cardiovascular complication of Kawasaki disease (KD), and recurrence of coronary thrombosis increases the short-term risk of myocardial infarction and the long-term risk of coronary artery disease. However, there are currently no studies predicting the recurrence of coronary thrombosis, so the aim of this study was to develop and validate a nomogram to predict recurrent coronary thrombosis in KD patients.

Methods: This was a retrospective study of data from 149 KD patients who had a history of previous coronary disease at the Children's Hospital of Chongqing Medical University from 2013 to 2020.

Secondary-ion-promoted active site redistribution in molecular sieves: A strategy to enhance catalyst bifunctionality.

As the frontier of environmental catalysis, mercury removal by deNO unit over bifunctional catalyst has emerged. However, it is fundamentally challenging to achieve simultaneous NO and mercury removal in industrial flue gas due to the commercial selective catalytic reduction (SCR) molecular sieves' lack of demercuration active centers. Herein, we demonstrate an active site in situ reconfiguration approach to enhance the oxidation of elemental mercury and immobilize divalent mercury by modified commercial SCR catalysts.

Unifying topological structure and self-attention mechanism for node classification in directed networks.

Graph data is essential for modeling complex relationships among entities. Graph Neural Networks (GNNs) have demonstrated effectiveness in processing low-order undirected graph data; however, in complex directed graphs, relationships between nodes extend beyond first-order connections and encompass higher-order relationships. Additionally, the asymmetry introduced by edge directionality further complicates node interactions, presenting greater challenges for extracting node information.

Predicting axillary lymph node metastasis in breast cancer using a multimodal radiomics and deep learning model.

Objective: To explore the value of combined radiomics and deep learning models using different machine learning algorithms based on mammography (MG) and magnetic resonance imaging (MRI) for predicting axillary lymph node metastasis (ALNM) in breast cancer (BC). The objective is to provide guidance for developing scientifically individualized treatment plans, assessing prognosis, and planning preoperative interventions.

Methods: A retrospective analysis was conducted on clinical and imaging data from 270 patients with BC confirmed by surgical pathology at the Third Hospital of Shanxi Medical University between November 2022 and April 2024.

Unveiling the Proton-Electron Transfer Pathway in Zn-Embedded N-Doped Carbon Catalyst for Enhanced CO Electroreduction.

Proton-electron transfer (PET) processes play a pivotal role in numerous electrochemical reactions; yet, effectively harnessing them remains a formidable challenge. Consequently, unveiling the PET pathway is imperative to elucidate the factors influencing the efficiency and selectivity of small molecule electrochemical conversion. In this study, a Zn-NC model catalyst with N and C vacancies was synthesized using a hydriding method to investigate the universal impact of PET on CO electroreduction.