Real-world comparison of palbociclib, abemaciclib, and dalpiciclib as first-line treatments for Chinese HR+/HER2-metastatic breast cancer patients: a multicenter study (YOUNGBC-28).

Background: In recent years, the combination of CDK4/6 inhibitors (CDK4/6i) and endocrine therapy (ET) has emerged as the standard first-line treatment for hormone receptor positive (HR+) and human epidermal growth factor receptor 2 negative (HER2-) metastatic breast cancer (MBC) patients. However, the comparison between the efficacy of CDK4/6i has been poorly explored before. Moreover, it remains unclear about the optimal choice of CDK4/6i in the first-line treatment for HR+/HER2- MBC patients in Asian, especially Chinese populations.

Association between Mediterranean diet adherence and Parkinson's disease: a systematic review and meta-analysis.

Background And Aims: Parkinson's disease (PD) is a chronic neurodegenerative disorder, and past research suggests that adherence to the Mediterranean diet (MD) may influence the risk of PD. However, there are varying conclusions among different studies regarding the correlation between long-term adherence to the MD and the occurrence of PD. This meta-analysis aimed to investigate the association between MD adherence and PD incidence.

One Stone for Multiple Birds: Copolymer with Multifunctional Groups Boosts the Cycling Stability of Lithium Cobalt Oxide Cathodes at 4.5 V.

High-voltage LiCoO is a promising cathode material for ultrahigh-energy lithium-ion batteries, particularly in the commercialization of 5G technology. However, achieving long-term operational stability remains a significant challenge. Herein, a quaterpolymer additive with multiple functional groups is introduced to enhance the electrochemical performance of LiCoO cathode at 4.

Artificial Intelligence-Based Classification of Anatomical Sites in Esophagogastroduodenoscopy Images.

Background: A full examination of gastrointestinal tract is an essential prerequisite for effectively detecting gastrointestinal lesions. However, there is a lack of efficient tools to analyze and recognize gastric anatomy locations, preventing the complete portrayal of entire stomach. This study aimed to evaluate the effectiveness of artificial intelligence in identifying gastric anatomy sites by analyzing esophagogastroduodenoscopy images.

A Novel Scoring System to Predict Acute Radiation Enteritis Recovery in Cervical Cancer Patients Undergoing Concurrent Chemoradiotherapy: A Southwest China Cohort Study.

Purpose: To establish a pragmatic and effective predictive model for monitoring the recovery of radiation enteritis (RE) in cervical cancer patients undergoing concurrent chemoradiotherapy (CCRT).

Methods: This study included 105 cervical cancer patients undergoing CCRT. We assessed baseline clinicopathologic characteristics, evaluated the effects of CCRT on circulating immune cells, tumor biomarkers, and inflammatory cytokines, and developed a predictive scoring system, the Immune-Tumor-Score (ITS), using the LASSO-Cox regression model.

Stable sequential dynamics in prefrontal cortex represents subjective estimation of time.

Time estimation is an essential prerequisite underlying various cognitive functions. Previous studies identified 'sequential firing' and 'activity ramps' as the primary neuron activity patterns in the medial frontal cortex (mPFC) that could convey information regarding time. However, the relationship between these patterns and the timing behavior has not been fully understood.

Prognostic factors of preterm neonates with gastrointestinal perforation: a retrospective cohort study from a tertiary neonatal center's 13-year experience in China.

This study aimed to describe the clinical features of preterm neonatal gastrointestinal perforation (GIP) and evaluate the prognostic factors. This retrospective study comprised 191 preterm neonates diagnosed with GIP, who were categorized into survival and non-survival groups. Clinical and demographic data, laboratory and imaging features, and outcomes were retrospectively collected.

Casticin inhibits proliferation of Non-small cell lung cancer cells through regulating reprogramming of glucose metabolism.

Background: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, with poor prognosis due to its rapid progression and resistance to existing therapies. Metabolic reprogramming, particularly alterations in glucose metabolism, is a key mechanism underlying tumor growth and progression, providing potential targets for novel therapeutic strategies. Casticin (CAS), a bioactive flavonoid, has shown anticancer effects in various cancers, but its specific role in NSCLC metabolism remains unclear.

Green entrepreneurial orientation and environmental performance a moderated mediation perspective of perceived environmental innovation and stakeholder pressure.

The current research examines how green entrepreneurial orientation affects environmental performance in Pakistan's manufacturing industries. It also examines the function of environmental innovation as a mediator in this relationship. In addition, stakeholder pressure is a moderating variable between green entrepreneurial orientation and environmental performance.

Metal-organic framework membranes with scale-like structure for efficient propylene/propane separation.

The fabrication of metal-organic framework (MOF) membranes with high propylene/propane selectivity, high mechanical endurance and ease of scaling up always remains a challenge. Inspired by the ubiquitous biological wear-resistant structure, here we show ZIF-67 membranes with a tangential-normal interlaced structure (TN-ZIF-67) for one-step acquisition of polymer-grade propylene, which is endowed with the merits of intergranular defect elimination, partial ZIF-67 lattice flexibility restriction and anti-wear of the membrane surface. The TN-ZIF-67 membrane exhibits an optimal propylene/propane mixture separation factor of 221, and the separation performance remained unchanged after 1.

Multi-scale structure and digestible process of wheat starch as affected by distribution behavior of rice glutelin amyloid fibril aggregates during gelatinization and digestion.

The effect of distribution behaviors of rice glutelin amyloid fibril aggregates (RAFA) on the structures and digestible process of wheat starch was investigated, and the interaction was revealed by molecular dynamics simulations. Rice glutelin (RG)/RAFA enhanced the long-range ordered structure of starch, and the relative crystallinity of gelatinized RAFA-wheat starch reached 14.35 %.

Structure and function of the human mitochondrial MRS2 channel.

The human mitochondrial RNA splicing 2 protein (MRS2) has been implicated in Mg transport across mitochondrial inner membranes, thus having an important role in Mg homeostasis critical for mitochondrial integrity and function. However, the molecular mechanisms underlying its fundamental channel properties such as ion selectivity and regulation remain unclear. Here we present a structural and functional investigation of MRS2.

Ultra-sensitive detection of norovirus using a three-in-one CRISPR platform based on a DNA hydrogel and composite functional nanomaterials.

The ultrasensitive sensor with three optical response mechanisms was proposed for the determination of trace amounts of norovirus using a 3-in-1 GCSNAs (a gap-containing spherical nucleic acid nanoparticles) probe. A simple and highly sensitive three-mode biosensor with Raman, colorimetric, and fluorescence functions was proposed and implemented using the GCSNAs probe and a DNA hydrogel for norovirus detection. When the virus exists, the trans-cleavage activity of CRISPR-Cas12a was activated by double-stranded dsDNA (dsDNA) generated by reverse transcription and recombinase polymerase isothermal amplification (RT-RPA) to degrade the DNA hydrogel/GCSNA composition and release the three-in-one (3-in-1) probe-GCSNA, realising the triple ultrasensitive detection of norovirus.

Quantification of intratumoral heterogeneity using habitat-based MRI radiomics to identify HER2-positive, -low and -zero breast cancers: a multicenter study.

Background: Human epidermal growth factor receptor 2-targeted (HER2) therapy with antibody-drug conjugates has proven effective for patients with HER2-low breast cancer. However, intratumoral heterogeneity (ITH) poses a great challenge in identifying HER2-low tumors. ITH signatures were developed by quantifying ITH to differentiate HER2-positive, -low and -zero breast cancers.

A novel multiple plant-based milk alternative containing various preprocessed grains achieves better performance in protein digestibility and free amino acid profile via in vitro gastrointestinal digestion analysis.

Plant-based milk alternatives are sustainable, hypoallergenic, and nutrient-rich, but challenges related to their lower bioavailability compared with animal-based milk still exist. In this study, we developed a multiple plant-based milk alternative using germinated soybeans and fermented cereals, and compared the protein digestible behaviors with commercial soy and bovine milk via in vitro gastrointestinal digestion. The multiple plant-based milk alternative possessed a higher level of essential amino acids and amino acid scores than the soy milk and a smaller percentage of low-molecular-weight peptides than the bovine milk.

Carnosol alleviates cisplatin-induced acute kidney injury by regulating apoptosis and pyroptosis.

The use of the common anticancer drug cisplatin (CP) in clinical practice often leads to acute kidney injury (AKI); however, no protective therapy is available. Therefore, new drugs that reduce the nephrotoxicity induced by CP are urgently needed. Carnosol (CA) is an antioxidant found.

A new benzodioxole derivative from the marine-derived sp. SYPHU 0002.

a new benzodioxole derivative 1,3-benzodioxole-2-one-4--methylcarboxylamide (), two new natural products -(aminocarbonyl)-2,3-dimethoxy-benzamide () and 2,3-dimethoxy--methylbenzamide (), along with eight known compounds (-), were isolated from the marine-derived sp. SYPHU 0002. The structures of compounds - were determined through comprehensive spectroscopic analyses, including HRESIMS, 1D and 2D NMR.

Effect of femoral prosthesis flexion angle on unicompartmental knee arthroplasty with mobile platform.

Objective: To investigate the effect of the flexion angle of a femoral prosthesis on the postoperative clinical outcome of patients with knee osteoarthritis who are undergoing unicompartmental knee arthroplasty.

Methods: Patients were divided into three groups according to the flexion angle of the femoral prosthesis following unicompartmental knee arthroplasty. Group A comprised patients with a flexion angle of the femur prosthesis of less than 5°, Group B included those with a flexion angle of 5° to 10°, and Group C consisted of patients with a flexion angle of the femur prosthesis greater than 10°.

Quercetin Alleviates Scleral Remodeling Through Inhibiting the PERK-EIF2α Axis in Experiment Myopia.

Purpose: This study aims to investigate the effect of quercetin (QUE) on scleral remodeling by inhibiting the PERK-EIF2α signaling pathway and to evaluate its potential role in slowing myopia.

Methods: Lens-induced myopia (LIM) guinea pigs were obtained and treated with QUE. After 4 and 6 weeks of treatments, ocular biological measurements were conducted.

Multi-cycle terahertz generation in lithium niobate wafer stacks via mid-infrared pumping.

Near-infrared laser-pumped optical rectification (OR) using quasi-phase matching (QPM) in lithium niobate (LN) is widely employed to generate multi-cycle terahertz (THz) pulses, which, however, suffer from low efficiency. Here, we demonstrate that mid-infrared pumping is an effective approach to increase the efficiency of multi-cycle THz generation. By using a 2.

High potential in synergizing the reduction of dissolved organic carbon concentration and carbon dioxide emissions for submerged-vegetation-covered river networks.

Various technologies and projects have been explored and developed for the synergetic control of environmental pollution and carbon emissions in aquatic ecosystems. Planting submerged vegetation in shallow waters was also expected to achieve this purpose. However, the magnitude and mechanism of carbon dioxide (CO) emission affected by submerged vegetation is not clear enough in complex aquatic ecosystems.