Based on metabolomics analysis: metabolic mechanism of intestinal tract of Scylla paramamosain under low-salt saline-alkali water aquaculture environment.

Background: In recent years, the total production of mud crab Scylla paramamosain has been declining, and the breeding areas are faced with land shortage and shortage of breeding production, which needs to be solved urgently. S. paramamosain can survive and grow in a wide range of salinities is an excellent variety suitable for saline-alkali water aquaculture.

A wearable triboelectric impedance tomography system for noninvasive and dynamic imaging of biological tissues.

Tissue imaging is usually captured by hospital-based nuclear magnetic resonance. Here, we present a wearable triboelectric impedance tomography (TIT) system for noninvasive imaging of various biological tissues. The imaging mechanism relies on the obtained impedance information from the different soft human tissues.

Intrinsically photosensitive polyimide photoresist and its double crosslinking mechanism.

A new negative-working photoinitiator-free polyimide was developed for photolithographic processes. The polyimide introduced a photosensitive benzophenone unit into the backbone and a cross-linking group (methacrylate) into the side chains. A novel pre-functionalized diamine monomer was designed to avoid using corrosive sulfonyl chloride in the polyimide side-chain introduction step.

The involvement of amyloid-β in the central nervous system regulation underlying sleep deprivation-induced rapid ejaculation in rats.

Background: Although some studies suggest that sleep deprivation may affect ejaculation regulation, related research is limited, and the mechanisms remain unclear.

Aim: This study aimed to explore whether sleep deprivation influences ejaculation regulation through amyloid-beta and to investigate its potential mechanisms.

Materials And Methods: Normal ejaculating rats were randomly distributed into three separate groups for the study, and treated with sleep deprivation combined with saline gavage, sleep deprivation combined with sodium butyrate gavage, and control with saline gavage.

ADAR1 is required for acute myeloid leukemia cell survival by modulating post-transcriptional Wnt signaling through impairing miRNA biogenesis.

Recent extensive studies on the genomic and molecular profiles of acute myeloid leukemia (AML) have expanded the treatment options, including, a range of compounds represented by fms-like tyrosine kinase 3 and isocitrate dehydrogenase 1/2 inhibitors. However, despite this progress, further treatments for AML are still required. Adenosine deaminase acting on RNA 1 (ADAR1) has been shown to play an important oncogenic role in many cancers, but its involvement in AML progression remains underexplored.

Rape Yield Estimation Considering Non-Foliar Green Organs Based on the General Crop Growth Model.

To address the underestimation of rape yield by traditional gramineous crop yield simulation methods based on crop models, this study used the WOFOST crop model to estimate rape yield in the main producing areas of southern Hunan based on 2 years of field-measured data, with consideration given to the photosynthesis of siliques, which are non-foliar green organs. First, the total photosynthetic area index (TPAI), which considers the photosynthesis of siliques, was proposed as a substitute for the leaf area index (LAI) as the calibration variable in the model. Two parameter calibration methods were subsequently proposed, both of which consider photosynthesis by siliques: the TPAI-SPA method, which is based on the TPAI coupled with a specific pod area, and the TPAI-Curve method, which is based on the TPAI and curve fitting.

Triggering Oxygen Redox Cycles in Nickel Ferrite by Octahedral Geometry Engineering for Enhancing Oxygen Evolution.

Spinel-type nickel ferrite (NiFeO, x≤1) is a widely used electrocatalyst for the oxygen evolution reaction (OER). Due to the lower hybridization of metal-d and oxygen-p orbitals, the OER process on NiFeO follows the sluggish adsorbate evolution mechanism (AEM). Generally, activating the lattice oxygen to trigger the lattice-oxygen-mediated mechanism (LOM) can enhance the OER activity.

Transcriptome Proffling, Physiological and Biochemical Analyses Reveal Comprehensive Insights into Cadmium Stress in .

With the expansion of cities and the development of industries, heavy metal pollution has caused a serious negative impact on the growth and development of animals and plants, which has become a global economic and social problem. Cadmium (Cd) is one of the main heavy metals that threaten the growth and development of plants, and it can lead to the imminent extinction of plants in severe cases. The part of upper reaches of the Yangtze River in China from Yibin to the Three Gorges Reservoir has been contaminated with varying degrees of Cd, and a rare and endangered plant called also lives in this area.

Enhancing treatment outcomes for Acute Periprosthetic Hip Joint infection: optimizing debridement, antibiotics, and Implant Retention through vacuum sealing drainage in the deep tissue.

Background: Debridement, antibiotics, and implant retention (DAIR) for acute periprosthetic joint infection (PJI) is under debated since the reported success rate is inconsistent. This study aimed to explore the efficacy of vacuum sealing drainage (VSD) used as an adjunct to irrigation and debridement for acute PJI.

Methods: Patients undergoing debridement, irrigation with component retention, and application of vacuum seal drainage in the deep portion surrounding the infected sites from January 2014 to February 2021 were retrospectively reviewed.

Unveiling 8,12-dimethoxysanguinarine: A Potent Inhibitor of Breast Cancer Metastasis via FN1 Downregulation.

This study investigated the effects of 8,12-dimethoxysanguinarine (DSG) from Eomecon chionantha Hance on the malignant biological activity of breast cancer cells. RNA-sequencing measure analysis revealed that metastasis-related genes were significantly downregulated in DSG-treated MCF-7 cells. DSG significantly inhibits the migration ability in MCF-7 cells.

Blacking any Material Surface by Amyloid-Fortified Carbon Coating Toward High-Performance Large-Scale Solar Steam Generation System.

Enhancing the interfacial adhesion between carbon-based coatings and substrates through a simple method remains a challenge, mainly due to the intrinsic chemical inertness of carbon materials. Herein, a carbon nanosphere-based coating utilizing an amyloid-like protein aggregation strategy is developed, involving only the reaction of protein, reductant, and carbon nanospheres in an aqueous solution at room temperature. The resultant coating, enriched in amyloid-like protein structures, features both robust interfacial adhesion and high light absorption (≈98.

Antiviral signaling of a type III CRISPR-associated deaminase.

Prokaryotes have evolved diverse defense strategies against viral infection, such as foreign nucleic acid degradation by CRISPR-Cas systems and DNA/RNA synthesis inhibition via nucleotide pool depletion. Here, we report an antiviral mechanism of type III CRISPR-Cas-regulated ATP depletion, where ATP is converted into ITP by CRISPR-Cas-associated adenosine deaminase (CAAD) upon activation by either cA or cA, followed by hydrolysis into IMP by Nudix hydrolase, ultimately resulting in cell growth arrest. The cryo-electron microscopy structures of CAAD in its apo and activated forms, together with biochemical evidence, revealed how cA/cA binds to the CARF domain and abrogates CAAD autoinhibition, inducing substantial conformational changes that reshape the structure of CAAD and induce its deaminase activity.

Triboelectric sensor with ultra-wide linear range based on water-containing elastomer and ion-rich interface.

The incompatibility of the high sensitivity and wide linear range still restricts the further development of active sensors. Here we report a triboelectric pressure sensor based on water-containing triboelectric elastomer with gradient-based microchannels. Tiny amount of liquid is injected into the triboelectric elastomer and the pressure-induced water bridges can modulate the built-in electric field of the sensor, which enhance the signal linearity near the compression limit.

Development of a PMGDNI model to predict the probability of three-month unfavorable outcome acute ischemic stroke after endovascular treatment: a cohort study.

Background: Patients with acute large vessel occlusion stroke (ALVOS) may exhibit considerable variability in clinical outcomes following mechanical thrombectomy (MT). This study aimed to develop a novel statistical model predicting functional independence three months post-endovascular treatment for acute stroke and validate its performance within the cohort.

Method: Consecutive patients undergoing endovascular treatment for acute stroke with large vessel occlusion were randomly divided into a modeling group and a validation group in a 7:3 ratio.

Depressive symptoms mediate the association between dietary inflammatory index and sleep: A cross-sectional study of NHANES 2005-2014.

Background: Sleep pattern (sleep duration, trouble sleeping, sleep disorder) is associated with both energy density dietary inflammatory index (EDII) and depression. However, whether depression mediates the EDII-sleep pattern relationship is unclear.

Methods: 14,305 participants from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2014 were included in this study.

Nutrient effects on plant diversity loss arise from nutrient identity and decreasing niche dimension.

Two hypotheses have been used to explain the loss of plant diversity with nutrient addition. The nutrient identity hypothesis posits that biodiversity loss is due to a specific limiting nutrient, such as nitrogen (N) or phosphorus (P), while the niche dimension hypothesis posits that adding a larger number of limiting nutrients, regardless of their identity, results in biodiversity loss. These two hypotheses have not previously been tested together simultaneously.

Carcinoma-Astrocyte Gap Junction Interruption by a Dual-Targeted Biomimetic Liposomal System to Attenuate Chemoresistance and Treat Brain Metastasis.

Brain metastasis contributes substantially to the morbidity and mortality of various malignancies and is characterized by high chemoresistance. Intracellular communication between carcinoma cells and astrocytes through gap junctions, which are assembled mainly by the connexin 43 protein, has been shown to play a vital role in this process. However, effectively blocking the gap junctions between the two cell types remains extremely challenging because of insufficient drug delivery to the target site.

An engineered α1β1 integrin-mediated FcγRI signaling component to control enhanced CAR macrophage activation and phagocytosis.

Treatment of solid tumors remains difficult, and therefore there has been increased focus on chimeric antigen receptor macrophages (CAR-M) to challenge solid tumors. However, CAR domain design of of adoptive cell therapy, which leads to differences in antitumor activity and triggered antitumor potential, remains poorly understood for macrophages. We developed an α1β1 integrin-mediated Fc-gamma receptor I (FcγRI) signaling component for CAR-M specific activation and its antitumor potential.

High-Precision Measurement Method for Small Angles Based on the Defect Spot Mode of the Position-Sensitive Detector.

The paper proposes and verifies a small-angle measurement method based on the defect spot mode of the position-sensitive detector (PSD). With the output characteristics of the PSD in the defect spot mode and the size transformation properties of a focused beam, the measurement sensitivity can be significantly improved. Calibration experiments with the piezoelectric transducer (PZT) indicate that compared with the current PSD-based autocollimation method, the proposed method can improve the sensitivity of small-angle measurement by 57 times, and the measurement sensitivity of the proposed method can be further improved by optimizing the system parameters, while the proposed method has the advantages of a simple system and high real-time performance.