Dietary 5-hydroxytryptophan supplementation improves growth performance and intestinal health of weaned piglets.

This study investigated the effects of dietary 5-hydroxytryptophan (5-HTP) supplementation on growth performance, apparent total tract digestibility (ATTD), blood profile, intestinal morphology, transcriptomics, and microbial composition in weaned piglets. A total of twenty-four 28-day-old weaned piglets (Landrace × Large Yorkshire, 8.28 ± 1.

Healthy eating patterns associated with reduced risk of inflammatory bowel disease by lowering low-grade inflammation: evidence from a large prospective cohort study.

Background: Limited epidemiological evidence exists regarding the role of healthy eating patterns in reducing the risk of Crohn's disease (CD) and ulcerative colitis (UC). This study aimed to investigate the association between adherence to four established healthy eating patterns and subsequent CD or UC risk, and further examined whether these associations are linked to anti-inflammatory mechanisms.

Methods: We conducted a prospective cohort study of 197,391 participants from the UK Biobank who completed at least one dietary questionnaire and were free from inflammatory bowel disease or cancer at baseline.

Ketogenic diet in treating sepsis-related acquired weakness: is it friend or foe?

Background: Sepsis is the body's extreme response to an infection leading to organ dysfunction. Sepsis-related acquired weakness (SAW), a critical illness closely related to metabolic disorders, is characterized by generalized sepsis-induced skeletal muscle weakness, mainly manifesting as symmetrical atrophy of respiratory and limb muscles. Muscle accounts for 40% of the body's total mass and is one of the major sites of glucose and energy absorption.

Tone classification of online medical services based on 1DCNN-BiLSTM.

In order to improve the recognition rate of the tone classification of doctors in online medical services scenarios, we propose a model that integrates a one-dimensional convolutional neural network (1DCNN) with a bidirectional long short-term memory network (BiLSTM). Firstly, significant tone types within online medical services scenarios were identified through a survey questionnaire. Secondly, 68 features in both the time and frequency domains of doctors' tone were extracted using Librosa, serving as the initial input for the model.

Unraveling chained optimization strategies for carbon emission control in WWTPs and effective water utilization within complicated water systems.

China faces severe water scarcity and significant greenhouse gas (GHG) emission pressures. As significant sources of GHG emission within urban system, wastewater treatment plants (WWTPs) exhibit a clear coupling relationship between wastewater treatment and urban water usage. However, the lack of trace of the water‑carbon nexus has created an obstacle to coordinating water utilization strategies and low-carbon wastewater treatment.

Constructing small for gestational age prediction models: A retrospective machine learning study.

Objective: To develop machine learning prediction models for small for gestational age with baseline characteristics and biochemical tests of various pregnancy stages individually and collectively and compare predictive performance.

Study Design: This retrospective study included singleton pregnancies with infants born between May 2018 and March 2023. Small for gestational age was defined as a birth weight below the 10th percentile according to the Intergrowth-21st fetal growth standards.

Solitary Scapula Metastasis From Intrahepatic Cholangiocarcinoma Detected by PET/CT.

A 59-year-old man presented with a mass and pain in the left side of his back for 6 months. 18F-FDG PET/CT demonstrated increased FDG uptake in the inferior aspect of his left scapula and the left hepatic lobe, highly suggesting the possibility of hepatic malignancy with solitary scapula metastasis. Finally, solitary scapula metastasis from intrahepatic cholangiocarcinoma was confirmed.

Surface engineering activation of mixed valence copper selenide: A high-performance anode for long life zinc-ion rock-chair batteries.

Rechargeable aqueous zinc-ion batteries (AZIBs) are an attractive alternative to lithium-ion batteries (LIBs) for large-scale energy storage, which offer high ionic conductivity and environmental advantages. However, challenges such as dendrite growth and limited coulombic efficiency (CE) limit electrochemical performance of AZIBs thus hindering their practical application. This study designs a polypyrrole (PPy)-coated copper selenide composite (CuSe@PPy) that works via Zn insertion/extraction mechanism.

Shared differential factors underlying individual spontaneous neural activity abnormalities in major depressive disorder.

Background: In contemporary neuroimaging studies, it has been observed that patients with major depressive disorder (MDD) exhibit aberrant spontaneous neural activity, commonly quantified through the amplitude of low-frequency fluctuations (ALFF). However, the substantial individual heterogeneity among patients poses a challenge to reaching a unified conclusion.

Methods: To address this variability, our study adopts a novel framework to parse individualized ALFF abnormalities.

Effects of adding niacinamide to diets with normal and low protein levels on the immunity, antioxidant, and intestinal microbiota in growing-finishing pigs.

This study aimed to investigate the effects of nicotinamide (NAM) applied to diets with different crude protein levels on immune function, antioxidant capacity, and intestinal flora in growing-finishing pigs. Forty barrows (37.0±1.

Systemic immune-related spleen radiomics predict progression-free survival in patients with locally advanced cervical cancer underwent definitive chemoradiotherapy.

Purpose: Systemic immunity is essential for driving therapeutically induced antitumor immune responses, and the spleen may reflect alterations in systemic immunity. This study aimed to evaluate the predictive value of contrast-enhanced CT-based spleen radiomics for progression-free survival (PFS) in patients with locally advanced cervical cancer (LACC) who underwent definitive chemoradiotherapy (dCRT). Additionally, we investigated the role of spleen radiomics features and changes in spleen volume in assessing systemic immunity.

Alterations of oral microbiome and metabolic signatures and their interaction in oral lichen planus.

Background: Oral lichen planus (OLP) is a chronic oral mucosal inflammatory disease with a risk of becoming malignant. Emerging evidence suggests that microbial imbalance plays an important role in the development of OLP. However, the association between the oral microbiota and the metabolic features in OLP is still unclear.

Comparative transcriptional analyses of the striatum in the chronic social defeat stress model in C57BL/6J male mice and the gut microbiota-dysbiosis model in Kumming mice.

Depression is a complex disorder with multiple contributing factors, and chronic stress has previously been recognized as a major causative factor, while gut microbes have also been found to be involved in depression recently. However, gene expression in depression models with different etiologies is unclear. Here, we compared the transcriptomes of the striatum in chronic social defeat stress (CSDS) model of C57BL/6J male mice and fecal microbiota transplant (FMT) model of Kumming male mice.

Identification of the m6A/m5C/m1A methylation modification genes in Alzheimer's disease based on bioinformatic analysis.

Background: As a progressive neurodegenerative disease, the comprehensive understanding of the pathogenesis of Alzheimer's disease (AD) is yet to be clarified. Modifications in RNA, including m6A/m5C/m1A, affect the onset and progression of many diseases. Consequently, this study focuses on the role of methylation modification in the pathogenesis of AD.

Molecular insights into biological transformation mechanism of sulfathiazole by Chlorella sorokiniana: Deciphering the uptake, translocation, and biotransformation.

As a sustainable approach to wastewater treatment, microalgae have been extensively used to degrade antibiotics. However, the underlying mechanisms involved in the degradation process remain unclear. Therefore, this study investigated the biotransformation mechanism of sulfathiazole (STZ) by Chlorella sorokiniana (C.

Neural and molecular investigation into the paraventricular thalamus for chronic restraint stress induced depressive-like behaviors.

Introduction: Disturbance of neural circuits and chronic stress contribute to depression onset. Given the crucial role of paraventricular nucleus of thalamus (PVT) in emotional behaviors, however, the specific neural and molecular mechanism of PVT in depression still unclear.

Objective: Our study aim to explore the neural and molecular mechanism of PVT in depression.

Neurofeedback technique for treating male schizophrenia patients with impulsive behavior: a randomized controlled study.

Background: Schizophrenia is one of the most severe mental disorders, frequently associated with aggression and violence, particularly in male patients. The underlying mechanisms of violent behavior in these patients remain unclear, limiting effective treatment options and highlighting the need for further research into interventions for impulsive behaviors. This study aims to evaluate the clinical efficacy of neurofeedback treatment in hospitalized male schizophrenia patients exhibiting impulsive behaviors.

A scoping review of preclinical intensive care unit-acquired weakness models.

Background: Animal models focusing on neuromuscular outcomes are crucial for understanding the mechanisms of intensive care unit-acquired weakness (ICU-AW) and exploring potential innovative prevention and treatment strategies.

Aim: To analyse and evaluate preclinical ICU-AW models.

Methods: We manually searched five English and four Chinese databases from 1 January 2002, to 1 February 2024, and reviewed related study references.