Stabilizing lattice oxygen interface with dual-functional NiFeO coating and Ni/Fe co-doping strategy towards high-performance sodium-ion layered oxide cathodes.

P2-NaMnFeNiO (MNF811) has garnered considerable attention due to its low cost and high energy density, while the poor structural and air stability and lattice oxygen evolution lead to undesirable electrochemical performance. Here, a NiFeO surface coating triggering a Ni/Fe co-doping strategy has been reported to suppress lattice oxygen evolution, eliminate poor air stability and mitigate the detrimental P2-OP4 phase transition. Furthermore, the NiFeO coating layer with air stability protects P2-NaMnFeNiO (MFN811@NF) cathode from reacting with moist air, and endows the P2-NaMnFeNiO electrode with three-dimensional fast sodium-ion diffusion channels and stable cathode/electrolyte interface (CEI), benefiting from the NiFeO coating layer.

Enhancing hydrogen evolution by heterointerface engineering of Ni/MoN catalysts.

Molybdenum nitrides have garnered significant attention for their potential in the hydrogen evolution reaction (HER) due to their metallic behavior, abundant reserves, and pH-universal stability. However, their unsatisfactory hydrogen adsorption limits industrial applications. Heterostructures can be designed to introduce defects and modulate the electronic structure of catalysts to optimize hydrogen adsorption to enhance HER.

Enhancing the Performance of Perovskite Environmental Sensors through the Synergistic Effect of the Natural Antioxidant.

All-inorganic perovskite CsPbX is considered to be the next-generation optical material due to its excellent optical properties and potential applications in optoelectronics. However, the inherent ionic crystal property makes it susceptible to interaction with moisture and oxygen in the ambient atmosphere and hinders the development of stable perovskite devices. Herein, a natural and nontoxic molecule, ascorbic acid (AA), is introduced to improve the performance of perovskite nanocrystals.

Improved object detection method for autonomous driving based on DETR.

Object detection is a critical component in the development of autonomous driving technology and has demonstrated significant growth potential. To address the limitations of current techniques, this paper presents an improved object detection method for autonomous driving based on a detection transformer (DETR). First, we introduce a multi-scale feature and location information extraction method, which solves the inadequacy of the model for multi-scale object localization and detection.

Application of Acinetobacter radioresistens to promote the growth of Cucumis sativus L. contaminated with polystyrene microplastics.

Currently, although many studies have successfully screened microorganisms with the ability to degrade microplastics (MPs), few studies have focused on their practical application and impacts on the soil-microbe-plant ecosystem. By adding polystyrene-microplastics (PS-MPs) and Acinetobacter radioresistens to the soil, this study aimed to assess their effects on the soil-microbe-plant ecosystem. The findings indicated that PS-MPs enhanced the growth of cucumber (Cucumis sativus L.

Protocol for alleviating alcohol-induced conditioned place preference in mice using alternating bilateral sensory stimulation.

Alternating bilateral sensory stimulation (ABS) is a clinical physical therapy technique effective in treating post-traumatic stress disorder (PTSD). However, its utilization in treating conditions beyond PTSD remains limited. Here, we present a protocol to reduce ethanol-induced conditioned place preference (CPP) using 4 Hz ABS.

An Analysis of the Effectiveness and Safety of Upadacitinib in the Treatment of Inflammatory Bowel Disease: A Multicenter Real-World Study.

Inflammatory bowel disease (IBD) requires effective treatment options. Upadacitinib, a Janus kinase 1 (JAK1) inhibitor, has shown effectiveness in trials for Crohn's disease (CD) and ulcerative colitis (UC). This study evaluates its real-world effectiveness and safety.

Compact high-bandwidth single-beam optically-pumped magnetometer for biomagnetic measurement.

Optically-pumped magnetometer (OPM) has been of increasing interest for biomagnetic measurements due to its low cost and portability compared with superconducting quantum interference devices (SQUID). Miniaturized spin-exchange-relaxation-free (SERF) OPMs typically have limited bandwidth (less than a few hundred Hertz), making it difficult to measure high-frequency biomagnetic signals such as the magnetocardiography (MCG) signal of the mouse. Existing experiments mainly use SQUID systems to measure the signal.

Monotropein attenuates renal cell carcinoma cell progression and M2 macrophage polarization by weakening NF-κB.

Purpose: The study aimed to investigate the effect and mechanism of monotropein on renal cell carcinoma (RCC).

Methods: After monotropein and NF-κB receptor activator (RANKL) treatment, cell proliferation, invasion, and apoptosis were evaluated using CCK-8, Transwell, and flow cytometry. Primary macrophages co-cultured with monotropein-treated RCC cells were analyzed to evaluate macrophage polarization using qRT-PCR, western blot, and ELISA assays by detecting the expression of M2 markers (CD206, CD168) and cytokines (IL-10, TGF-β).

Effectiveness of nurse-led care in patients with rheumatoid arthritis: a systematic review and meta-analysis.

Objectives: This study sought to assess the effectiveness of nurse-led care (NLC) in patients with rheumatoid arthritis (RA).

Methods: We conducted a comprehensive search of the Cochrane Library, Web of Science, PubMed, Embase, CINAHL, ClinicalTrials.gov databases and the references from relevant literature published prior to May 2023.

Effects of polystyrene microplastics on the growth and metabolism of highland barley seedlings based on LC-MS.

Microplastics are widely present in the environment and can adversely affect plants. In this paper, the effects of different concentrations of microplastics on physiological indices and metabolites of highland barley were investigated for the first time using a metabolomics approach, and revealed the response mechanism of barley seedlings to polystyrene microplastics (PS-MPs) was revealed. The results showed that the aboveground biomass of highland barley exposed to low (10 mg/L) and medium (50 mg/L) concentrations of PS-MPs increased by 32.

HMOX1-LDHB interaction promotes ferroptosis by inducing mitochondrial dysfunction in foamy macrophages during advanced atherosclerosis.

Advanced atherosclerosis is the pathological basis for acute cardiovascular events, with significant residual risk of recurrent clinical events despite contemporary treatment. The death of foamy macrophages is a main contributor to plaque progression, but the underlying mechanisms remain unclear. Bulk and single-cell RNA sequencing demonstrated that massive iron accumulation in advanced atherosclerosis promoted foamy macrophage ferroptosis, particularly in low expression of triggering receptor expressed on myeloid cells 2 (TREM2) foamy macrophages.

Full-length transcriptome annotation of a pyrosome, Pyrosoma atlanticum (Chordata, Thaliacea).

Pyrosomes represent a group of marine holozooplankton. They do not exist as individual entities but as intricate colonies comprising numerous zooids, well-known for their bioluminescent properties. Pyrosomes inhabit most oceanic waters spanning tropical to temperate regions.

Near-Infrared Light Driven Reversible Photoelectrochemical Bioassay by S-Scheme All-Polymer Blends for Acetylcholinesterase Activity Monitoring.

Photoelectrochemical (PEC) biosensing, recognized for its heightened sensitivity, faces limitations in its application for diagnosis due to the inefficiency of UV-visible light-driven photoactive materials in nontransparent biological samples. In this study, we investigate the potential of an S-scheme all-polymer heterojunction comprising a prototype nonfullerene polymeric acceptor (PYIT) and carbon nitride to develop a near-infrared (NIR) light-driven PEC biosensor for monitoring acetylcholinesterase activity in nontransparent human whole blood. The distinct molecular structure of PYIT enables efficient light absorption in the NIR region, enhancing sensitivity in nontransparent biological samples.

A phase III, randomized, controlled noninferiority trial to study the efficacy and safety of imipenem/cilastatin/relebactam (IMI/REL) vs piperacillin/tazobactam (PIP/TAZ) in patients with hospital-acquired bacterial pneumonia (HABP) or ventilator-associated bacterial pneumonia (VABP).

Objectives: Imipenem/cilastatin/relebactam (IMI/REL) is a β-lactam/β-lactamase inhibitor combination effective against gram-negative pathogens. Efficacy and safety of IMI/REL were studied in critically ill adults with hospital-acquired bacterial pneumonia (HABP) or ventilator-associated bacterial pneumonia (VABP).

Methods: In this phase III, double-blind, multinational, randomized trial (NCT03583333), adults with HABP/VABP were randomized 1:1 to receive intravenous IMI/REL (500 mg/250 mg) or piperacillin/tazobactam (PIP/TAZ; 4000 mg/500 mg) every 6 h for 7-14 days.

Road surface semantic segmentation for autonomous driving.

Although semantic segmentation is widely employed in autonomous driving, its performance in segmenting road surfaces falls short in complex traffic environments. This study proposes a frequency-based semantic segmentation with a transformer (FSSFormer) based on the sensitivity of semantic segmentation to frequency information. Specifically, we propose a weight-sharing factorized attention to select important frequency features that can improve the segmentation performance of overlapping targets.

Evaluating the diagnostic performance of [F]ALF-NOTA-FAPI-04 PET/CT in gastric cancer: a comparative study with [F]FDG PET/CT.

Purpose: To compare the diagnostic value of [F]ALF-NOTA-FAPI-04 positron emission tomography/computed tomography (PET/CT) and F-fluorodeoxyglucose (FDG) PET/CT in gastric cancer.

Methods: This single-center retrospective analysis included 65 patients with gastric cancer who received both [F]FDG and [F]ALF-NOTA-FAPI-04 PET/CT for initial staging or restaging. Histopathological manifestations, typical imaging manifestations, follow-up imaging, and comprehensive clinical assessment were used as reference criteria.

Rationale and Design of Dual Antiplatelet Therapy in Patients with Coronary Multi-Vessel Disease (DAPT-MVD): A Multicenter, Randomized, Controlled Trial.

Background: The optimal duration of dual antiplatelet therapy (DAPT) for patients with coronary multi-vessel disease (MVD) who have received drug-eluting stents (DES) remains unclear.

Hypothesis And Methods: The Dual Antiplatelet Therapy in Patients with Coronary Multi-Vessel Disease (DAPT-MVD) study is a multicenter, open-label, randomized controlled trial designed to assess the efficacy and safety of extended DAPT in MVD patients 12 months following DES implantation. We plan to enroll 8250 patients across approximately 100 sites in China.

N-Acetylneuraminic acid triggers endothelial pyroptosis and promotes atherosclerosis progression via GLS2-mediated glutaminolysis pathway.

Vascular endothelial injury initiates atherosclerosis (AS) progression. N-Acetylneuraminic acid (Neu5Ac) metabolic disorder was found to intensify endothelial mitochondrial damage. And GLS2-associated glutaminolysis disorder contributed to mitochondrial dysfunction.

The Differences Between Sculptra and AestheFill Reconstitution Processes.

Biostimulators have been increasingly popular for facial rejuvenation in recent years. Among them, Sculptra (based on poly-L-lactic acid (PLLA)) and AestheFill (based on poly-D,L-lactic acid (PDLLA)) are supplied as lyophilized powders in vials. Both need to be reconstituted with sterile water into homogeneous suspensions before injection.