Publications by authors named "Peng Wen"

Article Synopsis
  • * Denosumab is an anti-osteoporotic drug that reduces bone loss and may also improve aspects of sarcopenia, showing promise as a treatment for both conditions.
  • * Current research on Denosumab's effectiveness for sarcopenia, particularly in China, is limited, highlighting the need for further studies to better understand its mechanisms and impacts.
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The label probe plays a crucial role in enhancing the sensitivity of immunochromatographic assay. Time-resolved fluorescent microspheres (TRFMs) have provided accurate and reliable results for fast and immediate detection. In this study, parathion was used as a model molecule in the time-resolved fluorescence immunochromatographic assay (TRFICA) strip establishment using recognition element of anti-parathion nanobody (VHH9).

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Accurate monitoring of the depth of anesthesia (DoA) is essential for ensuring patient safety and effective anesthesia management. Existing methods, such as the Bispectral Index (BIS), are limited in real-time accuracy and robustness. Current methods have problems in generalizability across diverse patient datasets and are sensitive to artifacts, making it difficult to provide reliable DoA assessments in real time.

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The physiological and pharmacological benefits of hydrogen sulfide (HS) are well established, and various HS and persulfide donors have been developed. However, few studies have examined the pharmacokinetics of sulfur donors, as most activity and metabolism tests are conducted , limiting insights into their clinical applications. This study utilized butylphthalide (NBP), an approved drug for ischemic stroke, by integrating HS and persulfide moieties directly into NBP's carbonyl groups.

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Postoperative therapies for osteosarcoma present substantial challenges due to tumor recurrence and extensive bone defects. To tackle these challenges, laser powder bed fusion is utilized to fabricate biodegradable Zn-Li porous scaffolds that supress tumors and promote osteogenesis. After the structure design and composition selection, the Zn-0.

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The procedure of anterior cruciate ligament (ACL) allograft preparation can be divided into fresh-frozen method (FF-allograft) or freeze-dried method (FD-allograft). This study aims to biomechanically and histologically compare the graft to bone tunnel integration between the two allografts. In-vitro results indicated that FF-allograft and FD-allograft showed excellent biocompatibility and biomechanics, while FD-allograft showed a denser collagen fiber arrangement than FF-allograft and autograft.

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  • * Results indicated that severe OSAS significantly increases the risk of hypertension and that higher TyG-BMI levels correlate with an elevated risk of hypertension, especially in the highest quartile.
  • * TyG-BMI was found to mediate 41.3% of the association between OSAS and hypertension, highlighting its importance for evaluating hypertension risk in OSAS patients.
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A new type of label-free electrochemical immunosensor for the high-sensitivity determination of parathion was developed based on the oriented immobilization of nanobody (VHH9) on a gold nanoparticle-loaded polyvinyl alcohol/citric acid nanofiber membrane-modified electrode. The morphology characterization and assembly process of the modified materials were investigated using scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS). Under the optimum conditions, the label-free electrochemical immunosensor for parathion exhibited a linear range of 0.

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Efficient and simultaneous removal of anionic and cationic dyes from wastewater using low-cost and environmentally-friendly adsorbent is highly required. Herein, the carboxylated cellulose (carboxyl content: 2.97 mmol/g) derived from pomelo peel was extracted by a one-step HO/HSO-mediated oxidation method.

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As biodegradable materials, zinc (Zn) and zinc-based alloys have attracted wide attention owing to their great potential in biomedical applications. However, the poor strength of pure Zn and binary Zn alloys limits their wide application. In this work, a stir casting method was used to prepare the Zn-1Fe-Sr ( = 0.

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Article Synopsis
  • - The study highlights how intermittent fasting (IF) and combining it with isomalto-oligosaccharides (IMO) can help improve cognitive functions in mice fed a high-fat-high-fructose diet, with the combination treatment showing the best results.
  • - It suggests that these beneficial effects are linked to the suppression of specific signaling pathways related to inflammation and energy metabolism, as well as positive changes in the gut microbiome.
  • - The research indicates that IF + IMO not only promotes cognitive improvement but also counters cognitive decline associated with weight regain, presenting a new approach to addressing obesity-related cognitive issues.
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Background And Objective: Based on comprehensive network-pharmacology and molecular docking analysis, this study was intended to unveil the multiple mechanisms of Si-Ni-San (SNS) in treating anxious insomnia.

Methods: The compounds of SNS were meticulously analyzed, selected and standardized with references to their pharmacological attributes. The components included chaihu (Bupleurum chinense DC.

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  • Non-optimal temperature significantly contributes to global disease burden, but most studies have focused on outdoor temperatures, potentially leading to misclassification of personal temperature exposure.
  • The CKB-Air study analyzed temperature data from 477 participants across personal, household, and outdoor settings during summer and winter in China, recording around 88,000 person-hours of data.
  • The study found strong correlations between personal and household temperatures in winter and significant predictors for personal temperature exposure, achieving good prediction accuracy, while identifying a U-shaped relationship between personal temperature exposure and heart rate.
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Oxidized low-density lipoprotein (ox-LDL)-associated endothelial dysfunction is a critical factor in the initiation and progression of Atherosclerosis (AS). Annexin A1 is an important member of the annexin family. Despite its wide range of biological functions across various tissues and cells, the role of Annexin A1 in AS remains largely unexplored.

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  • * After exposure to PS-MPs, mice showed inflammation in various organs, as indicated by immune cell infiltration and increased proinflammatory signals, suggesting significant health impacts.
  • * Inflammatory responses were reduced when two specific receptors (TLR2 and TLR4) were inhibited, indicating a potential pathway for mitigating the effects of PS-MPs, although the specific macrophage response observed in vitro did not align with in vivo findings.
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  • Water pollution and agricultural waste are significant global challenges, prompting the creation of a biomass aerogel from waste taro stem microcrystalline cellulose (TS-MCC).
  • The optimized TS-MCC aerogel features a strong porous structure, high mechanical strength (65.04 kPa), and impressive adsorption capabilities for microplastics (418.6 mg/g) and dye (951.51 mg/g) across varying pH and ionic strength levels.
  • Adsorption mechanisms involve hydrogen bonding, electrostatic attractions, and π-π interactions, achieving high efficiencies even after multiple reuse cycles (92.37% for microplastics and 88.34% for dye), establishing it as an effective solution for contaminant removal.
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  • * The research involved a cohort of pregnant women to assess their dietary practices and the prevalence of obesity in their newborns, with findings showing 5.4% of neonates were obese.
  • * Key factors influencing neonatal obesity included increased fruit consumption and higher maternal education levels, indicating that promoting healthy diets and education can be effective in obesity prevention strategies.
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  • * The thioacid-modified NSAIDs demonstrate enhanced cyclooxygenase inhibition, potentially with better effectiveness, and avoid unnecessary structural changes, ensuring only the intended active ingredients are released.
  • * The design takes advantage of how esterases can efficiently break down thiocarboxylic acids for controlled HS release, and the study supports its concept through synthesis, kinetics assessment, pharmacological testing, and evaluations on toxicity and gut microbiota in animal models.
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Objective: Employing body composition analysis, this study aims to examine the influencing factors and conduct predictive analysis regarding sarcopenia incidence in the middle-aged and elderly population in China.

Methods: This study recruited inpatients from the General Medicine Department of Tongji Medical College Affiliated Union Hospital, Huazhong University of Science and Technology, as the subjects for a single-center retrospective study. Diagnosis was conducted according to the 2019 criteria from the Asian Working Group for Sarcopenia.

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Subways are widely used in major cities around the world, and subway fine particulate matter (PM) is the main source of daily PM exposure for urban residents. Exposure to subway PM leads to acute inflammatory damage in humans, which has been confirmed in mouse in vivo studies. However, the concrete mechanism by which subway PM causes airway damage remains obscure.

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  • The development of lithium metal batteries is challenged by poor electrochemical stability and low ionic conductivity in solid-state electrolytes.
  • A new azanide-based single-ion covalent organic framework (CN-iCOF) was designed, utilizing nitrile groups to enhance lithium ion transport and voltage stability.
  • This innovative framework demonstrated excellent Li dissociation, ionic conductivity at ambient temperature, and stable battery performance with high-voltage cathodes, showcasing its potential for improving high-performance batteries.
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Objective: Improved understanding of metabolic obesity phenotypes holds great promise for personalized strategies to combat obesity and its co-morbidities. Such investigation is however lacking in Tibetans with unique living environments and lifestyle in the highlands. Effects of altitude on heterogeneous metabolic obesity phenotypes remain unexplored.

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