Large-scale genomic and phenomic analyses of modern cultivars empower future rice breeding design.

Modern cultivated rice plays a pivotal role in global food security. China accounts for nearly 30% of the world's rice production and has bred numerous cultivated varieties over the last decades that are well adapted to diverse growing regions. However, the genomic bases that underlie the phenotypes of modern cultivars are poorly characterized, limiting access to this vast resource for breeding of specialized, regionally adapted cultivars.

Phosphorus Doping Coupled with Gradient Film Strategy to Achieve Thermochromic Performance Enhancement of VO.

Nonmetal elements have remarkable potential in modulating the metal-insulator transition behavior of VO, but little is known about their impact on thermochromic performance. Here, phosphorus (P) is successfully doped into VO by the precursor decomposition diffusion. XPS spectra, together with DFT calculations, demonstrate V-substitutional doping (Pv).

Highly Sensitive Detection of Engrailed-2 Protein Biomarker in Urine for Using Solution-Gated Graphene Transistor Diagnosis of Prostate Cancer.

Engrailed-2 (EN2) protein, a transcription factor in the homologous domain expressed in prostate cancer (PCa) cells and secreted into the urine, is considered a promising biomarker for noninvasive detection of PCa. EN2 protein in urine samples can be obtained by noninvasive means, but the low biomarker concentration in urine samples poses a great challenge for noninvasive detection of the PCa biomarker. Herein, we develop a solution-gated graphene transistor (SGGT) biosensor to detect the biomarker of the EN2 protein for PCa diagnosis.

The protective role of muscone in the development of COPD.

Background: Muscone, a key component of musk, exhibits anti-inflammatory properties. However, its therapeutic potential in inflammatory lung diseases, such as chronic obstructive pulmonary disease (COPD), remains largely unexplored. This study aimed to investigate whether Muscone could exert a protective effect in a mouse model of COPD .

Flexible TiCT MXene Film Coupled with Defect-Rich MoO Spacer-Contributor toward High-Performance Wearable Energy Storage.

MXene film-derived flexible supercapacitors have shown great application foreground for wearable electronics, but the capacitive characteristics, especially when faced with mechanical deformations, are not satisfactory. Herein, a new kind of flexible electrode, MX/D-MoO, is developed by using TiCT MXene film (MX) and defect-rich MoO (D-MoO) as the "main body" and "spacer-contributor", respectively. Results indicate that, with D-MoO intercalation, notably enlarged layer spacing of TiCT nanosheets and boosted electrochemical active sites are fulfilled, which have facilitated wondrous property increases of 342% and 239% when compared to raw MX and MX/MoO, respectively.

One-stop combined coronary-craniocervical computed tomography angiography with low-dose body coverage using artificial intelligence iterative reconstruction: a clinically feasible solution to multi-territorial atherosclerosis diagnosis.

Background: Computed tomography angiography (CTA) is an effective means to detect atherosclerosis yet a whole-body scan may involve excessive dose that can only be considered in extreme cases. This study is to test the feasibility and value of adding a low-dose body CTA to the combined coronary-craniocervical CTA by using artificial intelligence iterative reconstruction (AIIR).

Methods: A total of 100 patients scheduled for one-stop combined coronary-craniocervical CTA were enrolled to receive an extended CTA covering from intracranial to iliofemoral arteries, by adding a low-dose body CTA to the coronary-craniocervical CTA.

A multifunctional hydrogel of cellulose nanofiber/microfibrillated cellulose hierarchical network for photothermal antibacterial and all-solid supercapacitor assembly.

In recent years, flexible-hydrogel wearable devices have undergone rapid development while photothermal therapy, energy storage/conversion, and other fields have been widely developed and used. However, the poor mechanical properties of hydrogels can affect their stability and reliability in practical applications, and it is often difficult to achieve both excellent mechanical properties and multifunctional characteristics. This study prepared a hierarchical cellulose network/PVA multifunctional composite hydrogel (MCPH) using cellulose nanofiber as fine fibers and microfibrillated cellulose as coarse fibers.

Cost-effective whole-cell biosynthesis of ursodeoxycholic acid using engineered with a multienzyme cascade.

Ursodeoxycholic acid (UDCA) can be used as a drug to treat various liver and bile diseases. Currently, the biological synthesis of UDCA is predominantly conducted via a two-step enzymatic process in which synthesis is catalyzed by 7α-hydroxysteroid dehydrogenase (7α-HSDH) and 7β-hydroxysteroid dehydrogenase (7β-HSDH) in succession, utilizing chenodeoxycholic acid (CDCA) as the substrate. In this study, an engineered () strain, designated UCA23, was constructed.

Characterization of the Pore Structure and Influencing Factors of CH Adsorption Capacity in Marine Shale Gas Reservoirs.

To enhance the understanding of the gas-bearing characteristics of marine shale gas reservoirs, shale samples from well ZG3, southern Sichuan Basin, China, were selected as the focus of this study. A series of analyses, namely total organic carbon (TOC) content, large-field stitching scanning electron microscope technology (LFS-SEM), X-ray diffraction (XRD), gas adsorption (CO+N), and CH adsorption experiment, were conducted to characterize the micropore structure of the shale comprehensively. Utilizing fractal theory, the study explored the relationships among the shale pore structure, organic pore content, heterogeneity, and CH adsorption capacity.

Accurate Diagnosis of Pancreatic Ductal Adenocarcinoma by Detection of miRNA-196a Biomarker in Exosome Using Solution-Gated Graphene Transistor with Antifouling Design.

The accurate diagnosis of pancreatic ductal adenocarcinoma (PDAC) suffers low specify, and low sensitivity of biomarker detection. In complex biological fluid environments, nonspecific adsorption is prevalent, posing challenges to the accurate detection of biomarkers at low concentrations. Herein, a highly sensitive and selective solution-gated graphene transistor (SGGT) is fabricated for the detection of miRNA-196a in exosomes to diagnose PDAC.

Efficacy of Multidisciplinary Pain Management for Advanced Cancer Patients.

Objectives: The objective of this study is to assess the efficacy and affecting factors of a multidisciplinary team (MDT) on cancer-related pain in patients with advanced cancer.

Methods: A retrospective analysis was performed on patients receiving pain management from November 2018 to December 2023 by the MDT. Pain intensity, pain management index (PMI), pain response, and Barthel index of activities of daily living (BADL) were assessed at baseline and/or after 2 weeks of MDT interventions.

Clinical and Multiorgan Proteomics Characteristics of the Diverse Fatal Phase in Super Elderly Patients With SARS-CoV-2 Infection: A Descriptive Study.

This study aims to identify the risk factors associated with clinical outcomes and the proteomic changes in organs related to fatal SARS-CoV-2 infection within the super-elderly population. This retrospective analysis included all elderly individuals with COVID-19 admitted to the Second Medical Center of PLA General Hospital from December 2022 to January 2023. The follow-up period ended on March 30, 2023.

Primary pulmonary adenoid cystic carcinoma: A study of clinicopathological features and molecular alterations in twenty-one cases.

Background: Primary pulmonary adenoid cystic carcinoma (PACC) is a rare malignant tumor. Despite the growing sophistication of ACC research, scant studies have delved into the unique molecular alterations of ACC originating from the lung and the clinical features associations.

Method: Paraffin-embedded specimens of primary PACC tissues pathologically confirmed at the Affiliated Hospital of Qingdao University within the past decade were collected.

The influence of the position and quantity of thiophene or acetylene groups on the photoelectric properties of dye-sensitized solar cells.

To investigate the influence of the position and quantity of thiophene or acetylene groups on the photoelectric properties of dye-sensitized solar cells (DSSCs), density functional theory (DFT) were employed to simulate five zinc porphyrin dye molecules (T-3, T-3-D, T-3-A, T-3-AD, and T-3-ace). The optimized geometry indicated that T-3-ace possessed superior planar properties, attributed to incorporating the acetylene groups, facilitating the charge transfer process. The lower lowest unoccupied molecular orbital (LUMO) energy levels of T-3-ace and T-3-D suggested that introducing thiophene or acetylene groups on the donor side enhanced the electron absorption capability of the dyes.

Study on the Influence of External Electric Field Control and Vibrational Quantum Effect on the Charge Separation Mechanism in Fullerene-Based Systems.

Based on the DCV-C system of fullerene acceptor organic solar cell active materials, the charge transfer process of D-A type molecular materials under the action of an external electric field () was explored. Within the range of electric field application, the excited state characteristics exhibit certain regular changes. Based on reducing the excitation energy, the excitation mode shows a trend of developing toward low excited states.

Cardiac computer tomography-derived radiomics in assessing myocardial characteristics at the connection between the left atrial appendage and the left atrium in atrial fibrillation patients.

Objectives: To evaluate the feasibility of utilizing cardiac computer tomography (CT) images for extracting the radiomic features of the myocardium at the junction between the left atrial appendage (LAA) and the left atrium (LA) in patients with atrial fibrillation (AF) and to evaluate its asscociation with the risk of AF.

Methods: A retrospective analysis was conducted on 82 cases of AF and 56 cases in the control group who underwent cardiac CT at our hospital from May 2022 to May 2023, with recorded clinical information. The morphological parameters of the LAA were measured.

Disrupted Paraventricular Hypothalamic Nucleus Functional Connectivity in Parkinson's Disease With Constipation.

Background: Constipation is one of the most common non-motor symptoms in patients with Parkinson's disease (PD), which could manifest during the early stage of the disease. However, the etiology of constipation in PD remains largely unknown. Previous studies supported that gastrointestinal dysfunction may be associated with functional connectivity alterations in paraventricular hypothalamic nucleus (PVN).

W/Mo/Cr Doping Modulates the Negative-Positive Inversion Gas Sensing Behavior of VO(M1).

The anomalous gas sensing behavior has garnered significant attention from researchers, prompting a re-evaluation of the gas sensing theory. This work focuses on inversion gas sensing behavior induced by element doping. W/Mo/Cr-doped VO(M1) samples are synthesized, and their sensing behaviors are investigated.

Dual Roles of Heterotrophic Ammonia-Oxidizing Bacteria in Enhancing Compensatory Growth upon Post-Drought in Maize.

This study investigates the mechanisms driving maize compensatory growth upon post-drought, to reveal how the root's original cytokinins are regulated by the two-fold roles of heterotrophic bacteria with ammonia-oxidizing (HAOB) capabilities. The HAOB' dual roles encompass influencing root cytokinin synthesis and transport through nitrification and a direct pathway. Experiment 1 involved introducing the application of varying amounts of NO to the roots to examine how nitrification affects cytokinin roots-to-leaves transport.

Interaction of inflammatory factors related to pulmonary infection and TLR4/NF-κB signaling pathway in patients with spontaneous intracerebral hemorrhage.

Objective: To investigate the interaction of inflammatory factors related to pulmonary infection and the TLR4/NF-κB signaling pathway in patients with spontaneous intracerebral hemorrhage (ICH).

Methods: A total of 325 critically ill ICH patients treated in our hospital from May 2021 to February 2024 were selected for this study. Based on whether the patient developed a pulmonary infection during treatment, they were divided into the infection group (n = 86) and the non-infection group (n = 239).

Spatial distribution of bacteria in response to phytoplankton community and multiple environmental factors in surface waters in Sanggou Bay.

Coastal bays link terrestrial and oceanic carbon reservoirs and play important roles in marine carbon cycles. Particulate organic carbon (POC) produced by phytoplankton is a major autochthonous carbon source in coastal bays. Previous studies on the fate of POC produced by phytoplankton mainly focused on the relationship between phytoplankton and zooplankton in classic food webs, while our knowledge on the roles of bacterioplankton is still limited, particularly in bays under highly intensive aquaculture activities.

Theoretical Insights into High- Superconductivity of Structurally Ordered YThH: A First-Principles Study.

There has been a marked increase in interest in high-temperature superconductors over the past few years, sparked by their potential to revolutionize multiple fields, including energy generation and transportation. A particularly promising avenue of exploration has emerged in the form of ternary superhydrides, compounds composed of hydrogen along with two other rare-earth elements. Our investigation focuses on the search for Y-Th-H ternary compounds; employing an evolutionary search methodology complemented by electron-phonon calculations reveals a stable superhydride, 6̅2-YThH, capable of exhibiting a critical temperature ( ) as high as 222 K at 200 GPa along a few low- novel hydrides.

Aberrant brain structural-functional coupling and structural/functional network topology explain developmental delays in pediatric Prader-Willi syndrome.

Prader-Willi syndrome (PWS) is a neurodevelopmental disorder characterized by dysplasia in early life. Psychoradiology studies have suggested that mental and behavioral deficits in individuals with PWS are linked to abnormalities in brain structural and functional networks. However, little is known about changes in network-based structural-functional coupling and structural/functional topological properties and their correlations with developmental scales in children with PWS.

Novel Selectivity: Target of Gas Sensing Defined by Behavior.

Traditional selectivity of gas sensors determined by the magnitude of the response value has significant limitations. The distinctive inversion sensing behavior not only defies the traditional sensing theory but also provides insight into defining selectivity. Herein, the novel definition of selectivity is established in a study with VO(M1).

Endoscopic ultrasound-guided biliary drainage percutaneous transhepatic biliary drainage for malignant biliary obstruction after endoscopic retrograde cholangiopancreatography failure.

In a recent issue of the , a meta-analysis investigated the safety and efficacy of electrocautery-enhanced lumen-apposing metal stent (ECE-LAMS) implantation for managing malignant biliary obstruction following failed endoscopic retrograde cholangiopancreatography. This manuscript endeavors to offer a comprehensive look at the progression of endoscopic ultrasound-guided biliary drainage (EUS-BD) technologies, weighing their merits and drawbacks against traditional percutaneous methods. Several meta-analyses and randomized controlled trials have compared the performance of EUS-BD and percutaneous transhepatic cholangiodrainage (PTCD).