Preoperative integrated oxidative stress score as a prognostic factor for predicting clinical outcomes in breast cancer patients received neoadjuvant chemotherapy: a real-world retrospective study.

The current study aims to investigate the prognostic value of breast cancer integrated oxidative stress score (BCIOSS) in patients with breast cancer who received neoadjuvant chemotherapy (NACT). A retrospective analysis of 104 breast cancer patients who underwent NACT from June 2009 to December 2015 was performed. The differences of BCIOSS of breast cancers in regard to variables were analyzed using Chi-square test and Fisher's exact test.

Bi-functional transcription factor SlbHLH95 regulates fruits flavonoid metabolism and grey mould resistance in tomato.

Flavonoids are polyphenolic secondary metabolites in tomato fruit with important roles in nutritional quality. Dissecting the transcriptional regulatory network modulating flavonoid metabolism is the first step to improve the nutritional quality of tomato fruits through molecular breeding technology. In this study, we identified a transcription factor SlbHLH95 as a key regulator in flavonoid metabolism through analysis of the MicroTom Metabolic Network (MMN) data set.

Anti photoaging mechanism of a novel recombinant human fibronectin peptide (rhFNP) derived from the extracellular matrix.

Photoaging is a major cause of skin ageing. Ultraviolet radiation is a key factor in this process, as it can increase the expression of inflammatory factors, promote an inflammatory response, and disrupt the balance between extracellular matrix (ECM) synthesis and degradation, resulting in impaired skin barrier function and increased skin sensitivity. Therefore, anti-inflammation and ECM remodelling are important directions in skin anti-aging research.

Burden of periodontal diseases in young adults.

We aimed to provide a comprehensive overview of the global burden of periodontal disease among young adults over the period from 1990 to 2019. The analysis considered various factors such as age, sex, country, and Socio-demographic Index (SDI). This study utilized GBD 2019 database to examine the trends in both incidence and disability-adjusted life years (DALY) rates of periodontal diseases among young adults from 1990 to 2019.

Integrating an entropy-driven DNA circuit with a tetrahedral scaffold as a generic electrochemical biosensor for amplified detection of microRNAs.

Detection of carcinogenesis-related miRNAs presents significant challenges due to their low abundance and high specificity, necessitating highly sensitive and reliable analytical methods. Herein, we propose a generic electrochemical biosensor for the sensitive and effective detection of miRNAs by rationally integrating an entropy-driven DNA circuit (EDC) with a tetrahedral scaffold. The key advancement of this work is the implementation of tetrahedral DNA nanostructures (TDNs) as both a scaffold and substrate for the EDC directly on the electrode surface.

Roles and therapeutic opportunities of ω-3 long-chain polyunsaturated fatty acids in lung cancer.

Over the past decades, researchers have continuously investigated the potential functions of long-chain polyunsaturated fatty acids (LCPUFAs) in cancers, including lung cancer. The ω-3 LCPUFAs, primarily consisting of eicosapentaenoic acid and docosahexaenoic acid, were found to modify inflammatory tumor microenvironment, induce cancer cell apoptosis and autophagy, and suppress tumor development when administered alone or with other therapeutical strategies. Although the precise anti-tumor mechanism has not been elucidated yet, ω-3 LCPUFAs are often used in the nutritional treatment of patients with cancer due to their ability to significantly improve patient's nutritional status, increase the sensitivity of tumor cells to treatments, and alleviate cancer-related complications.

Human Tyrosinase Displayed on the Surface of Chinese Hamster Ovary Cells for Ligand Fishing of Tyrosinase Inhibitors from Medicinal Plants.

Ligand fishing is a promising strategy for the screening of active ingredients from complex natural products. In this work, human tyrosinase (hTYR) was displayed on the surface of Chinese hamster ovary (CHO) cells for the first time; it was then used as bait to develop a new method for ligand fishing. The localization of hTYR on the CHO cell surface was verified by an enzyme activity test and fluorescence microscopy.

α-arbutin prevents UVA-induced skin photodamage via alleviating DNA damage and collagen degradation in NIH-3T3 cells.

Ultraviolet radiation (UV) causes certain side effects to the skin, and their accumulation to a certain extent can lead to accelerated aging of the skin. Recent studies suggest that α-arbutin may be useful in various disorders such as hyperpigmentation disorders, wound healing, and antioxidant activity. However, the role of α-arbutin in skin photodamage is unclear.

The association between stent design and patient exercise intensity: structural coupling effects and hemodynamic analysis.

Introduction: In-stent restenosis remains a significant challenge in coronary artery interventions. This study aims to explore the relationship between exercise intensity and stent design, focusing on the coupled response of the stent structure and hemodynamics at different exercise intensities.

Methods: A coupled balloon-stent-plaque-artery model and a fluid domain model reflecting structural deformation were developed to investigate the interaction between coronary stents and stenotic vessels, as well as their impact on hemodynamics.

An integrated transcriptomic analysis of brain aging and strategies for healthy aging.

Background: It is been noted that the expression levels of numerous genes undergo changes as individuals age, and aging stands as a primary factor contributing to age-related diseases. Nevertheless, it remains uncertain whether there are common aging genes across organs or tissues, and whether these aging genes play a pivotal role in the development of age-related diseases.

Methods: In this study, we screened for aging genes using RNAseq data of 32 human tissues from GTEx.

The impact of different treatments on thromboelastography and other conventional parameters in patients with colorectal cancer.

Objective: To comprehend the effects of diverse therapeutic interventions on thromboelastography (TEG) and conventional coagulation parameters among individuals diagnosed with colorectal cancer, this study aims to explore the clinical relevance of both thromboelastography and conventional coagulation metrics in evaluating coagulation function and predicting the incidence of thrombotic and hemorrhagic events in patients with colorectal cancer.

Methods: A cohort of 122 patients with colorectal cancer retrospectively recruited and divided into 2 groups: those undergoing surgical intervention (operation group) and those not subjected to surgery (non-operation group). According to the different types of treatment they received, the operation group was divided into chemotherapy-only group and a group receiving a combination of targeted therapy and chemotherapy.

Effects of individualized dietary programs provided by nurses on nutrition and micro-inflammation of patients undergoing peritoneal dialysis (PD): A non-randomized controlled study.

This study aimed to assess the effects of individualized dietary programs provided by nurses on the nutrition and micro-inflammation of patients undergoing peritoneal dialysis (PD). This study employed the convenience sampling method for selecting participants. Accordingly, 60 patients undergoing PD who visited a PD center from January to June 2022 were selected as the control group, and 60 patients undergoing PD who visited the same PD center from November 2022 to April 2023 were selected as the intervention group.

Effect of multidisciplinary medical nutrition therapy on the nutrition status of patients receiving peritoneal dialysis: A randomized controlled trial.

Background: Malnutrition is a prevalent complication in patients undergoing peritoneal dialysis (PD). This study established a multidisciplinary team for medical nutrition therapy (MNT) to investigate the impact of this approach on enhancing the nutrition, anemic, and microinflammatory status of patients receiving PD.

Methods: This randomized controlled trial study involved 81 patients undergoing PD (n = 41 in the intervention group, n = 40 in the control group).

Casting New Light on the Retinol and Retinyl Palmitate Functions as Chemical Enhancers for Transdermal/Topical Drug Delivery.

Retinol and retinyl palmitate, with excellent whitening and antioxidant activities, are widely used as essential functional ingredients in transdermal preparations and skincare products. Herein, for the first time, the influence and underlying mechanisms of retinol and retinyl palmitate on the skin penetration of caffeine are investigated. It is found that the penetration of caffeine is very significantly enhanced by retinol and retinyl palmitate with 2.

Chinese herbal medicine (JianPi-BuShen) and completion rate of adjuvant chemotherapy for patients with stage II and III colon cancer: A randomized clinical trial.

Purpose: Many cancer patients express interest in using herbal medicine during chemotherapy, but little is known about its benefits and risks. This study aimed to evaluate the effects of the Chinese herbal medicine JianPi-BuShen formula (JPBS) on adjuvant chemotherapy completion in colon cancer patients.

Patients And Methods: This multi-center, phase III, randomized, placebo-controlled trial included patients with stage II (high risk for recurrence) and stage III colon cancer following surgery, planning to receive CAPOX (capecitabine and oxaliplatin) chemotherapy.

Efficacy and safety of Atractylodes macrocephala-containing traditional Chinese medicine combined with neoadjuvant chemotherapy in the treatment of advanced gastric cancer: a systematic evaluation and meta-analysis.

Background: In China, Atractylodes-containing Chinese medicines are widely used as adjuvant therapy to neoadjuvant chemotherapy (NAC) in individuals diagnosed with advanced gastric cancer (AGC). Nevertheless, the findings concerning its effectiveness are still restricted. The aim from this research was to examine the efficiency and security Atractylodes macrocephala-containing traditional Chinese medicine together with NAC in the management of AGC.

Systemic immune-inflammation index values are associated with non-melanoma skin cancers: evidence from the National Health and Nutrition Examination Survey 2010-2018.

Introduction: The systemic immune-inflammation index (SII), based on peripheral lymphocyte, neutrophil, and platelet counts, has recently been investigated as a prognostic marker in several tumors. However, the SII has rarely been reported in skin cancers. In this study, we aimed to assess the association between SII values and the risk of occurrence of skin cancers.

The effect of multiple single cannulation technique on complications of arteriovenous fistulae: A meta-analysis.

Objective: To evaluate the effect of multiple single cannulation technique on the complications of arteriovenous fistula.

Methods: A comprehensive literature search was conducted to investigate the impact of multiple single cannulation technique on the complications of arteriovenous fistula. The search was performed in both Chinese and English databases including Wanfang Medicine, China National Knowledge Infrastructure, Vip, Pubmed, Embase, and The Cochrane Library, with a search period up to December 20, 2023.

Fast Screening of Tyrosinase Inhibitors in Nutt. by Ligand Fishing Based on Paper-Immobilized Tyrosinase.

Nutt. is an important medicinal plant in traditional Uyghur medicine. The skin-lightening potential of the flower has been recognized recently; however, the active compounds responsible for that are not clear.

N-acetylgalactosaminyltransferase GALNT6 is a potential therapeutic target of clear cell renal cell carcinoma progression.

High expression of truncated O-glycans Tn antigen predicts adverse clinical outcome in patients with clear cell renal cell carcinoma (ccRCC). To understand the biosynthetic underpinnings of Tn antigen changes in ccRCC, we focused on N-acetylgalactosaminyltransferases (GALNTs, also known as GalNAcTs) known to be involved in Tn antigen synthesis. Data from GSE15641 profile and local cohort showed that GALNT6 was significantly upregulated in ccRCC tissues.