Publications by authors named "Peng S"

Article Synopsis
  • The study aimed to explore how salivary properties, body fat, and dental caries were related in Hong Kong adolescents aged 12-15.
  • It involved 921 participants from local schools, with a focus on measuring dental health (using the DMFT index), saliva characteristics, and body measurements to analyze correlations.
  • Results indicated that adolescents with higher caries levels had poorer salivary flow and buffering capacity, alongside higher body fat, suggesting a possible connection between body fat and dental health.
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  • The text discusses a theory related to the circulatory system's flow and its connection to the disease myasthenia gravis, highlighting deficiencies and disarrangements in the body.
  • It suggests that acupuncture diagnosis and treatment should target restoring balance to the middle organs and enhancing the functions of other organs to combat health issues.
  • The goal of this approach is to improve both motor and non-motor functions, including movement, speech, and mental health in affected patients.
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  • The study investigates a deep learning algorithm, ResCANet, designed to accurately delineate clinical target volumes for cervical and endometrial cancer during radiotherapy, assessing its effectiveness in various patient groups.! -
  • It involved a total of 332 patients, with a focus on performance metrics such as dice similarity coefficient and sensitivity, showing promising results in both internal (e.g., 74.8% DSC) and external validations (e.g., 77.1% DSC for endometrial cases)! -
  • The findings suggest that ResCANet effectively supports automatic delineation with minimal revisions needed, enhancing efficiency and demonstrating generalizability across different cancer types.!
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  • * The study introduces a mechanical immune checkpoint inhibitor (MICI) that uses cyclodextrin (CD) lipids to reduce cholesterol in tumor cell membranes, resulting in stiffer cells that trigger better lymphocyte activation.
  • * This approach shows promising results in mouse models for breast cancer and melanoma, and highlights a new mechanical factor in boosting the immune response against tumors without negatively impacting lymphocyte activity.
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  • Sepsis-induced acute lung injury (ALI) involves severe lung inflammation and cell death, with the underlying mechanisms not fully understood, leading researchers to study the role of sirtuin 4 (SIRT4) in this condition.
  • Experiments using cell and animal models demonstrated that higher SIRT4 levels improved cell survival, reduced inflammation, and enhanced overall health in both cultured cells and CLP rats, suggesting SIRT4 has protective effects against sepsis-induced ALI.
  • The findings revealed that SIRT4 alleviates lung injury by inhibiting specific signaling pathways (JAK2/STAT3 and PI3K/AKT/mTOR), indicating that increasing SIRT4 could be a new treatment strategy for this type
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The demand for food has increased dramatically as the global population increases, putting more strain on the sustainability of agriculture. To fulfill this requirement, it is imperative to develop brand-new technologies. The application potential of nanozymes in the plant and environmental sectors is progressively becoming apparent as a result of their effective enzymatic catalytic activity and the distinctive characteristics of nanomaterials, including size, specific surface area, optical properties, and thermal properties.

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  • * 390 adults with diabetes in Changsha, China participated, leading to the development of the Brief Diabetic Foot Risk Screening Scale with 6 dimensions and 19 items after thorough analysis.
  • * Results demonstrated strong validity and reliability, with good content validity (I-CVI > 0.8), internal consistency (Cronbach's α = 0.770), and excellent test-retest reliability (0.958), indicating the scale effectively identifies diabetic foot risk.
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  • The Board of International Human Phenome Consortium (IHPC) is instrumental in guiding the global Human Phenome Project, focusing on large-scale biomedicine research to understand human phenomes.* -
  • A recent virtual meeting showcased advancements in phenomics, including the development of the first human phenome Atlas, which aids in understanding limb growth, disease prevention, and early diagnosis.* -
  • The board discussed frameworks for phenome measurements, the PhenoBank Initiative, and the importance of standardized platforms and databases for efficient research collaboration.*
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Pyroxenes (AMXO) consisting of infinite one-dimensional edge-sharing MO chains and bridging XO tetrahedra are fertile ground for finding quantum materials. Thus, here, we have studied calcium cobalt germanate (CaCoGeO) and calcium cobalt silicate (CaCoSiO) crystals in depth. Heat capacity data show that the spins in both compounds are dominantly Ising-like, even after being manipulated by high magnetic fields.

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  • Cerebrovascular disease (CVD) is a major cause of dementia, and detecting vascular cognitive impairment (VCI) in these patients is a significant challenge.
  • Researchers analyzed clinical and neuroimaging data from 307 CVD subjects to create a multimodal deep learning model using vision transformer and extreme gradient boosting techniques.
  • The hybrid model achieved strong performance, comparable to expert clinicians, and is capable of highlighting important brain regions and clinical features that aid in the diagnosis of VCI, making it a valuable tool for clinical decision support.
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Surface electromyography (sEMG) is a widely employed bio-signal that captures human muscle activity via electrodes placed on the skin. Several studies have proposed methods to remove sEMG contaminants, as non-invasive measurements render sEMG susceptible to various contaminants. However, these approaches often rely on heuristic-based optimization and are sensitive to the contaminant type.

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  • Despite advances in treatment for HER2-positive breast cancer, many patients face drug resistance that negatively impacts their survival.
  • This study created a risk model using data from TCGA and GEO to predict patient outcomes and identify key genes related to drug resistance, focusing on 5 specific genes.
  • It revealed that MED1, along with two other genes, plays a significant role in drug resistance, suggesting that targeting MED1 could be a promising strategy to overcome this challenge.
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Psoriasis is a chronic autoimmune disease that badly affects the life quality of patients and their families. Inadequate efficacy, safety risks, high cost and low compliance of current psoriasis drugs urge development of novel small molecular drugs. In this study, two series of 37 novel compounds were designed and synthesized as inhibitors of phosphodiesterase 4 (PDE4) that specifically hydrolyzes second messenger cAMP and is an effective target for treatment of inflammatory diseases.

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The development of bifunctional photogenerated carrier-assisted electrocatalytic (PCA-EC) electrodes that operate with stability at large current-density remains a significant challenge. Herein, we demonstrate a simple sputtering-deposition process to synthesize a novel MnWO/FeCoNi Mott-Schottky heterojunction coating and deposit it on a pure Ti substrate to prepare high-performance PCA-EC electrodes, which exhibits enhanced light absorption range/intensity and rapidly separated photogenerated electron-hole pairs. This design allows photogenerated electrons to directly participate in the hydrogen evolution reaction (HER), while the strong oxidation of photogenerated holes significantly reduces the defect formation energy of active metals, thereby facilitating the rapid reconstruction of highly active Ni(FeCo)OOH/MnOOH species for the oxygen evolution reaction (OER).

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  • Some studies suggest that autoimmune disorders might be related to prostate cancer, but it's not clear how or if they're connected.
  • Researchers looked at various autoimmune diseases to see if any are linked to the risk of getting prostate cancer.
  • Their results showed that certain autoimmune diseases, like rheumatoid arthritis, could increase the risk of prostate cancer, while others, like autoimmune hyperthyroidism, might protect against it.
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  • Aggression is a major issue in society, particularly among neuropsychiatric patients, but its underlying neural mechanisms and treatment options remain unclear.
  • Researchers analyzed data from 182 Vietnam War veterans with head injuries to identify a specific brain network linked to aggression, finding a key hub in the right prefrontal cortex and other connected regions.
  • The study suggests that targeting this aggression-associated brain circuit through neuromodulation methods, like deep brain stimulation, could be a potential therapeutic approach for managing aggression-related symptoms.
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Traditionally, the classification of HIV-1 M group subtypes has depended on statistical methods constrained by sample sizes. Here HIV-1-M-SPBEnv was proposed as the first deep learning-based method for classifying HIV-1 M group subtypes via env gene sequences. This approach overcomes sample size challenges by utilizing artificial molecular evolution techniques to generate a synthetic dataset suitable for machine learning.

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  • Researchers found that studying brain activity in different people can be tricky because it doesn’t always give the same results.
  • They discovered that while individual brain activity during working memory tasks is different, there are common networks that our brains use.
  • Using a special technique called activation network mapping, they showed that understanding these brain networks can help predict how well someone performs on memory tasks, which is even better than just looking at brain activity alone.
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Background: Previous research revealed an association between coffee consumption and depressive symptoms. However, the results differed between studies in adults and adolescents. Additionally, limited research on coffee and depressive symptoms has distinguished between black and sugar-sweetened coffee.

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Central venous access devices (CVADs) are integral to cancer treatment. However, catheter-related thrombosis (CRT) poses a considerable risk to patient safety. It interrupts treatment; delays therapy; prolongs hospitalisation; and increases the physical, psychological and financial burden of patients.

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While community walkability is recognized as a key environmental factor for health status, evidence linking it specifically to hypertension is rather limited. To fill the knowledge gap, we concluded a cross-sectional study among 6421 eligible participants from the Wuhan Chronic Disease Cohort. A well-developed algorithm was performed to evaluate community walkability across Wuhan, quantified as Walk Score.

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  • Alcohol is the most widely consumed and abused psychoactive drug, yet the brain mechanisms behind its effects are not fully understood.
  • Researchers identified a protein called TMEM132B, which acts as an auxiliary subunit for GABA receptors, influencing their functioning and how alcohol impacts them.
  • In experiments with mice lacking TMEM132B, researchers found decreased GABA transmission and heightened compulsive alcohol consumption, suggesting TMEM132B-GABA interactions are important for understanding alcohol’s effects and related behaviors.
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  • Harsh climatic conditions and lack of topsoil in China's cold resistance zone pose challenges for ecological restoration of open-pit mine dumps, leading researchers to develop synthetic soil using mineral black clay.
  • The introduction of an ecological restoration bacteria (ERB) consortium significantly altered the native bacterial community structure, increasing diversity by combating the dominance of inhibitory bacteria.
  • This microbial alteration improved soil composition and plant diversity, promoting the growth of Salsola collina and Medicago sativa, enhancing nutrient cycling, and fostering beneficial plant-microbe interactions for successful ecological remediation.
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Recently, pyrene-based covalent organic frameworks (PyCOFs) have aroused great interest because the large planar structure of the pyrene unit could effectively enhance the interlayer π-π interaction and promote the separation and migration of carriers, significantly improving the crystallinity and photoelectrical properties of PyCOFs. Since the first PyCOF-containing boroxate linkage was reported in 2008 by the Yaghi group, many PyCOFs with different kinds of linkages have been reported, exhibiting great potential applications in different fields such as adsorption/separation, chemical sensing, catalysis, energy storage, However, as far as we know, the reviews related to PyCOFs are rare, although PyCOFs have been widely reported to show promising applications. Thus, it is right time and important for us to systematically summarize the research advance in PyCOFs, including the synthesis with different linkages and applications.

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