[Updated reproductive toxicology of polybrominated diphenyl ether].

Since 1970, polybrominated diphenyl ether (PBDE) has been widely used as additive flame retardants in everyday consumer products, including polyurethane foam and electronic products like mattresses and upholstered furniture. Thermoplastics, mixed in polymers, do not chemically bond with plastics, textiles, etc., and therefore can be separated from the product into the environment.

Implementation and validation of an in-house geometry optimization software for SRS VMAT planning of multiple cranial metastases.

Purpose: The implementation and evaluation of an in-house developed geometry optimization (GO) software are described. The GO script provides optimal lesion clustering, isocenter placement, and collimator angle of each arc for cranial multi-lesion stereotactic radiosurgery (SRS) volumetric modulated arc therapy (VMAT) planning.

Materials And Methods: An Eclipse-plugin program was developed to facilitate automatic plan geometry generation for multiple metastases SRS VMAT plans.

[Distribution and Drug Sensitivity of Pathogens Causing Nosocomial Infection in Patients with Hematological Granulocytosis].

Objective: To investigate the distribution and drug resistance of nosocomial infection pathogens in AL patients with hematological agranulocytosis, so as to provide evidence for the clinical rational use of antibiotics.

Methods: Pathogenic data of 504 hospitalized patients with agranulocytosis caused by nosocomial infection in the Department of Hematology, the First Hospital of Lanzhou University from May 2015 to May 2018 were collected and retrospectively analyzed for the distribution of pathogenic bacteria and the results of drug susceptibility.

Results: The isolated pathogenic bacteria strains amounted to 184, out of which, 168 strains (91.

Interaction between TaNOX7 and TaCDPK13 Contributes to Plant Fertility and Drought Tolerance by Regulating ROS Production.

Reactive oxygen species (ROS) homeostasis is critical for both physiological processes and stress responses of plants. NADPH oxidases (NOXs) are the key producers of ROS in plants. However, their functions in ROS homeostasis and plant growth regulation in wheat () are little investigated.

[Clinical Features of Nosocomial Infections in Agranulocytosis Patients with Hematological Malignancies and Analysis of Risk Factors].

Objective: To explore the clinical features and risk factors for nosocomial infections in agranulocytosis patients with hematological malignancies so as to provide basis for clinical prevention and treatment of nosocomial infections.

Methods: The clinical data of 725 patients with agranulocytosis in the First Hospital of Lanzhou University from May 2015 to May 2018 were retrospectively analyzed, including sex, age, primary disease, treatment stage, agranulocytosis degree, agranulocytosis duration, nosocomial infection, infectous site, average length of stay and average days of infection. Univariate analysis (Chi-square test) and multivariate analysis (non-conditional Logistic regression models) were used to analyze the risk factors of nosocomial infection.

Using HJ-CCD image and PLS algorithm to estimate the yield of field-grown winter wheat.

Remote sensing has been used as an important means of estimating crop production, especially for the estimation of crop yield in the middle and late growth period. In order to further improve the accuracy of estimating winter wheat yield through remote sensing, this study analyzed the quantitative relationship between satellite remote sensing variables obtained from HJ-CCD images and the winter wheat yield, and used the partial least square (PLS) algorithm to construct and validate the multivariate remote sensing models of estimating the yield. The research showed a close relationship between yield and most remote sensing variables.

NADPH Oxidases: The Vital Performers and Center Hubs during Plant Growth and Signaling.

NADPH oxidases (NOXs), mostly known as respiratory burst oxidase homologs (RBOHs), are the key producers of reactive oxygen species (ROS) in plants. A lot of literature has addressed ROS signaling in plant development regulation and stress responses as well as on the enzyme's structure, evolution, function, regulation and associated mechanisms, manifesting the role of NOXs/RBOHs as the vital performers and center hubs during plant growth and signaling. This review focuses on recent advances of NOXs/RBOHs on cell growth, hormone interaction, calcium signaling, abiotic stress responses, and immunity.

Quantitative monitoring of leaf area index in wheat of different plant types by integrating NDVI and Beer-Lambert law.

Normalized difference vegetation index (NDVI) is one of the most important vegetation indices in crop remote sensing. It features a simple, fast, and non-destructive method and has been widely used in remote monitoring of crop growing status. Beer-Lambert law is widely used in calculating crop leaf area index (LAI), however, it is time-consuming detection and low in output.

Calmodulin Is the Fundamental Regulator of NADK-Mediated NAD Signaling in Plants.

Calcium (Ca) signaling and nicotinamide adenine dinucleotide (NAD) signaling are two basic signal regulation pathways in organisms, playing crucial roles in signal transduction, energy metabolism, stress tolerance, and various developmental processes. Notably, calmodulins (CaMs) and NAD kinases (NADKs) are important hubs for connecting these two types of signaling networks, where CaMs are the unique activators of NADKs. NADK is a key enzyme for NADP (including NADP and NADPH) biosynthesis by phosphorylating NAD (including NAD and NADH) and therefore, maintains the balance between NAD pool and NADP pool through an allosteric regulation mode.

[Values of Different Prognostical Score Systems in Evaluation of Clinical Efficacy for Patients with Newly Diagnosed Chronic Myeloid Leukemia].

Objective: To explore the values of 4 prognostic score systems in evaluation of clinical effecacy for patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatnib mesylate (IM) and the relationship between 4 prognostic score systems and deep molecular response (MR4.5).

Methods: The clinical data of 240 CML-CP patients treated with imatinib mesylate in our hospital between Janunay 2008 and December 2017 were analyzed retrospecively.

[Clinical Analysis of Serum Calcium Level in 86 Cases of Newly Diagnosed Multiple Myeloma].

Objective: To investigate the serum calcium level in 86 patients with newly diagnosed multiple myeloma (MM) and its correlation with clinical features.

Methods: The clinical data of 86 patients with newly diagnosed multiple myeloma in our hospital from 2009 to 2016 were retrospectively analyed. Clinical data of sex, age, hemoglobin, albumin, globulin, creatinine, uric acid, serum phosphorus, β2-microglobulin, immunophenotyping and disease staging were collected.

Genome-Wide Identification and Functional Analysis of NADPH Oxidase Family Genes in Wheat During Development and Environmental Stress Responses.

As the key producers of reactive oxygen species (ROS), NADPH oxidases (NOXs), also known as respiratory burst oxidase homologs (RBOHs), play crucial roles in various biological processes in plants with considerable evolutionary selection and functional diversity in the entire terrestrial plant kingdom. However, only limited resources are available on the phylogenesis and functions of this gene family in wheat. Here, a total of 46 NOX family genes were identified in the wheat genome, and these NOXs could be classified into three subgroups: typical TaNOXs, TaNOX-likes, and ferric reduction oxidases (TaFROs).

[Soil quality assessment under different cropping system and straw management in farmland of arid oasis region].

To reveal the regulatory mechanism of agricultural management practices on soil quality, an experiment was carried out to study the different cropping system and straw management on soil organic carbon and fractions and soil enzyme activity in farmland of arid oasis region, which would provide a scientific basic for enhancing agricultural resources utilization and sustainable development. In crop planting planning area, we took the mainly crop (cotton, wheat, maize) as research objects and designed long-term continues cropping and crop rotation experiments. The results showed that the soil organic carbon (SOC), soil microbial biomass C, labile C, water-soluble organic C, and hot-water-soluble organic C content were increased by 3.

Cellular and Molecular Basis of Neurodegeneration in Parkinson Disease.

It has been 200 years since Parkinson disease (PD) was described by Dr. Parkinson in 1817. The disease is the second most common neurodegenerative disease characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta.

Diabetes Mellitus and Alzheimer's Disease: The Protection of Epigallocatechin-3-gallate in Streptozotocin Injection-Induced Models.

Diabetes mellitus is considered as a risk factor of Alzheimer's disease (AD), the front runner of neurodegenerative disorders. Streptozotocin (STZ) is a toxin for pancreatic β-cell, which can construct a model of insulin deficient diabetes through intraperitoneal or intravenous injection. A model generated by intracerebroventricular STZ (icv-STZ) also shows numerous aspects of sporadic AD.

Noninvasive evaluation of corneal viscoelasticity based on displacement in response to acoustic radiation force.

Noninvasive assessment of corneal mechanical properties in vivo will help to the understanding of the pathogenesis and early diagnosis of ectatic corneal disorders. This study presented a noninvasive method that assesses the corneal biomechanical properties by exciting the cornea with acoustic radiation force and monitoring its displacement using a dual-frequency confocal transducer. A 3.

Toll-like receptor 2 and dectin-1 function as promising biomarker for infection.

In recent years, along with the wide application of organ transplantation and immunosuppressive agents, as well as the abuse of broad spectrum antibiotics, the incidence of invasive fungal infections has been increasing gradually. The present study aimed to identify novel biomarkers in cells infected with . Human umbilical vein endothelial cells (HUVECs) were infected with and then harvested at different time-points (0, 1, 2, 4 and 6 h).

Enantioselective Total Synthesis of (-)-Pavidolide B.

The enantioselective synthesis of (-)-pavidolide B (1) was achieved in a linear sequence of 10 steps. The key steps are (a) an enantioselective organocatalytic cyclopropanation; (b) a radical-based cascade annulation for the regio- and diastereo-selective synthesis of the highly functionalized lactone 3 bearing the characteristic tricyclic core and seven contiguous stereocenters;

Influenza virus non‑structural protein 1 inhibits the production of interferon β of alveolar epithelial cells upon the infection of influenza A H1N1.

Influenza A affects a large population worldwide. Influenza virus evades immune responses via various mechanisms, including through the modification of the immune microenvironment. Influenza virus non‑structural protein 1 (NS1) encoded by the virus genome inhibits type I interferon (IFN) signaling pathways, which is essential for viral clearance.