Acid-responsive aggregated carrot-derived nanoantioxidants alleviate oxidative stress and restore osteoblast activity.

Background: Excessive generation of reactive oxygen species is a hallmark of the osteoporotic bone microenvironment, which leads to the damage of mitochondrial function and the deactivation of osteoblasts. Fruits and vegetables are rich sources of antioxidants, which play a key role in scavenging free radicals and maintaining the body's homeostasis.

Results: Herein, we have developed a type of vesicle coming from carrots as nanoantioxidants to counteract oxidative stress and restore the vitality of osteoblasts for reversing osteoporosis.

Building trisubstituted ethylenes from terminal alkenes debrominative ring-opening trifluoromethylations of geminal dibromocyclopropanes.

CuI-catalyzed regio- and stereoselective dehalogenative ring-opening trifluoromethylations of geminal dibromo- or dichlorocyclopropanes or monobromocyclopropanes delivered stereodefined trisubstituted or disubstituted ethylenes bearing a CHCF group in good yields. Purple light-promoted reductive monodebromination of -dibromocyclopropanes was also developed.

Study on Differential Metabolite Active Ingredients in Maize Roots Based on Network Pharmacology and Metabolomics Analysis.

Maize is a globally important crop. Roots are the main part of maize and are mainly used for soil improvement and for maintaining crop growth as agricultural waste. Their application scope is relatively small.

Maize 4-coumarate coenzyme A ligase gene positively regulates drought stress response in .

Maize is a major food crop in China, and drought is one of the major abiotic stresses that threaten the growth and development of the crop, seriously affecting the crop yield. 4-coumaric acid coenzyme A ligase () is a key enzyme in the phenylpropane metabolic pathway, which can regulate the lignin content of the plant and play an important role in the plant's resistance to drought stress, plays an important role in plant resistance to drought stress. In the present study, we screened the differentially expressed up-regulated gene under drought stress by pre-transcriptome sequencing data (PRJNA793522) in the laboratory, and analyzed the significant up-regulation of gene in roots under drought stress by qRT-PCR(Real-Time Quantitative Reverse Transcription PCR).

Nanocomposite hydrogels optimize the microenvironment by exterior/interior crosstalk for reprogramming osteoporotic homeostasis in bone defect healing.

Discovering new tactics for healing bone defects becomes a worldwide challenge in osteoporosis patients. The disordered acidic microenvironment plays a pivotal role in driving the imbalance of bone homeostasis regulated by osteoblasts and osteoclasts. However, the scarcity of hydrogel materials developed to optimize local bone microenvironment has made osteoporotic defect healing more challenging.

Carbonized Wood Decorated with Ternary Heterogeneous MoS-MoP-MoC Nanoparticles for pH-Universal Hydrogen Evolution.

The assembly of diverse active materials significantly enhances the efficiency of the electrocatalytic hydrogen evolution reaction (HER). Herein, we prepare a three-phase composite structure electrocatalyst on carbonized wood, in which molybdenum carbide and molybdenum phosphide are attached to molybdenum sulfide nanosheets (MoS-MoP-MoC@CW) through the hydrothermal method in combination with high-temperature calcination for a pH-universal HER. MoS possesses abundant unsaturated coordination edge active sites, thus facilitating the adsorption and desorption of the hydrogen intermediate (H*).

Comparison of the mid-term outcomes of laparoscopic and percutaneous nephroscopic laser unroofing for the treatment of single renal cyst: a single-center retrospective study.

Purpose: Renal cysts are the most common benign disease of the kidneys, and their increasing size cause compression symptoms that require surgical intervention. In this study, we compared the safety, efficacy and prognosis of percutaneous nephroscopic laser unroofing (PNLU) with those of laparoscopic unroofing (LU) for simple renal cysts.

Methods: Data from patients with single renal cysts who underwent PNLU or LU between Jan 2018 and Dec 2023 were collected and followed up thereafter.

Quantifying the Pore Characteristics and Heterogeneity of the Lower Cambrian Black Shale in the Deep-Water Region, South China.

Recently, significant breakthroughs have been made in the exploration of shale gas in the Lower Cambrian black shale of the Sichuan Basin, indicating a promising commercial extraction potential. However, there remains considerable controversy regarding the pore structural characteristics for this shale formation, especially in the deep-water region. To address this, this paper focused on core samples from two shale gas wells (Xa1 and Xb1) located in the slope-basin facies zone during the Early Cambrian.

CRISPR-Cas9-mediated editing of gene improves tolerance to drought stress in maize.

Maize ( L.) is a widely grown food crop around the world. Drought stress seriously affects the growth and development process of plants and causes serious damage to maize yield.

miR166e/ZmATHB14 module contributes to drought tolerance in maize root.

MicroRNAs significantly influence abiotic stress responses. A species-conserved miRNA implicated in the response to abiotic stress is maize miR166. Therefore, it is unknown whether miR166e plays a role in maize roots' reaction to drought stress.

Low-Energy Delicate Pulsed Light Therapy for Sensitive Skin: A Retrospective Study.

Background: Sensitive skin (SS) is a multifactorial syndrome that affects about half of the world's population. However, there is no standardized treatment protocol. Photovoltaic technology has been widely used in recent years for the treatment of sensitive skin, but the efficacy of low-energy delicate pulsed light (DPL) in the treatment of sensitive skin is unknown.

Adiponectin deficiency prevents chronic colitis-associated colonic fibrosis via inhibiting CXCL13 production.

Introduction: Colonic fibrosis is a long-term complication of inflammatory bowel disease (IBD), often leading to functional impairment, intestinal obstruction, and surgery. Adiponectin (APN) is an adipokine derived from adipocytes that plays a pleiotropic role in fibrosis regulation, depending on tissue and cell type specific or disease context, but its role in colonic fibrosis remains unclear.

Objective: To explore the role and involved mechanism of APN in chronic colitis-associated colonic fibrosis.

, a maize NF-Y transcription factor, positively regulates drought and salt stress response in .

Maize ( L.) is a major food and feed crop and an important raw material for energy, chemicals, and livestock. The NF-Y family of transcription factors in maize plays a crucial role in the regulation of plant development and response to environmental stress.

Ultrahigh Plateau-Capacity Sodium Storage by Plugging Open Pores.

Hard carbon (HC) stands out as the most promising anode material for sodium-ion batteries (SIBs), and a precise adjustment of the pore structure is the key to achieving high plateau-capacity. In this work, composite hard carbon is developed by integrating graphitic carbon with biomass waste (banana peel)-derived activated carbon (AC). In this design, N-doped pseudographite layer is stacked at the entrance of open pores, forming a long-range graphitic layer without excessive graphitization.

Clinical Pharmacist Involved in the Treatment of Pneumonia: A Case Report.

Objective: The first-line treatment for severe pneumonia (PCP) is trimethoprim-sulfamethoxazole (TMP/SMZ). Here, we report a case involving 6-month-old child with a PCP infection, highlighting the role of clinical pharmacists in providing individualized pharmaceutical care and guidance through the process of therapeutic drug monitoring (TDM).

Methods: The clinical pharmacist monitored the concentration of TMP/SMZ in the serum, urine and sputum of a 6-month-old child with PCP infection.

Alterations of Ceramides, Acylcarnitines, GlyceroLPLs, and Amines in NSCLC Tissues.

Abnormal lipid metabolism plays an important role in cancer development. In this study, nontargeted lipidomic study on 230 tissue specimens from 79 nonsmall cell lung cancer (NSCLC) patients was conducted using ultraperformance liquid chromatography-high-resolution mass spectrometry (UPLC-HRMS). Downregulation of sphingosine and medium-long-chain ceramides and short-medium-chain acylcarnitine, upregulation of long-chain acylcarnitine C20:0, and enhanced histamine methylation were revealed in NSCLC tissues.

Regulates to Promote the Accumulation of Florigen and Accelerate Flowering.

Auxin response factors(ARFs) are a class of transcription factors that regulate the expression of auxin response genes and play a crucial role in plant growth and development. Florigen plays a crucial role in the process of flowering. However, the process by which auxin regulates the accumulation of florigen remains largely unclear.

Liver Function-Related Indicators and Risk of Gallstone Diseases-A Multicenter Study and a Systematic Review and Meta-Analysis.

We aim to examine the association between liver function-related indicators and gallstone disease (GSD) risk. The subjects who participated in the China Multicenter Physical Examination Cohort (CMPEC) were enrolled. Relative odds ratios (ORs) with 95% CIs and standardized mean differences (SMDs) were applied to investigate the effect of liver function-related indicators and GSD risk.

Contrast-enhanced computed tomography-based radiomics nomogram for predicting HER2 status in urothelial bladder carcinoma.

Objective: To evaluate the performance of a clinical-radiomics model based on contrast-enhanced computed tomography (CE-CT) in assessing human epidermal growth factor receptor 2 (HER2) status in urothelial bladder carcinoma (UBC).

Methods: From January 2022 to December 2023, 124 patients with UBC were classified into the training (n=100) and test (n=24) sets. CE-CT scans were performed on the patients.

Integrating commercial graphite with network-like carbon fibers for high-rate and long-term cycling K-storage.

K can reversibly intercalate into graphite by forming KC (279 mA h g, ≈0.2 V) in conventional carbonate electrolytes, but the large ionic radius of K (1.38 Å) easily results in structural degradation and rapid capacity decay.

Clinical and molecular significance of homologous recombination deficiency positive non-small cell lung cancer in Chinese population: An integrated genomic and transcriptional analysis.

Objective: The clinical significance of homologous recombination deficiency (HRD) in breast cancer, ovarian cancer, and prostate cancer has been established, but the value of HRD in non-small cell lung cancer (NSCLC) has not been fully investigated. This study aimed to systematically analyze the HRD status of untreated NSCLC and its relationship with patient prognosis to further guide clinical care.

Methods: A total of 355 treatment-naïve NSCLC patients were retrospectively enrolled.