Effectiveness of high-intensity inspiratory muscle training, and resistance and aerobic exercise for cardiovascular health in chronic obstructive pulmonary disease (HIRAC-COPD): a randomized controlled trial protocol.

Background: Cardiovascular diseases are among the most common and clinically significant comorbidities of chronic obstructive pulmonary disease (COPD). Exercise has been shown to reduce the risk of cardiovascular diseases, and high-intensity inspiratory muscle training (H-IMT) has emerged as a promising intervention for improving arterial stiffness in individuals with COPD. Yet, there is limited evidence from randomized controlled trials (RCTs) regarding the impact of H-IMT alone or in combination with exercise on reducing arterial stiffness in COPD.

Balancing growth and preservation: Unravelling Africa's carbon-economic nexus through the environmental kuznets curve.

Africa is vulnerable to the challenges of global climate change, which poses a significant obstacle to achieving economic development while protecting the environment. Despite numerous Environmental Kuznets Curve (EKC) studies, evidence remains inconclusive, especially in African countries. This study delves into the carbon-economic nexus within the EKC framework across 46 African countries from 1990 to 2020.

Holistic numerical simulation of a quenching process on a real-size multifilamentary superconducting coil.

Superconductors play a crucial role in the advancement of high-field electromagnets. Unfortunately, their performance can be compromised by thermomagnetic instabilities, wherein the interplay of rapid magnetic and slow heat diffusion can result in catastrophic flux jumps, eventually leading to irreversible damage. This issue has long plagued high-J NbSn wires at the core of high-field magnets.

RNAi Screen Identifies AXL Inhibition Combined with Cannabinoid WIN55212-2 as a Potential Strategy for Cancer Treatment.

: Cannabinoids are commonly used as adjuvant cancer drugs to overcome numerous adverse side effects for patients. The aim of this study was to identify the target genes that show a synergistic anti-tumor role in combination with the cannabinoid WIN55212-2 in vitro and in vivo. : A human kinome RNAi library was used to screen the targeted gene that silencing plus WIN55212-2 treatment synergistically inhibited cancer cell growth in an INCELL Analyzer 2000.

Association between per- and polyfluoroalkyl substance exposures and thyroid homeostasis parameters.

Context: Prevailing studies have shown the disruption effect of per- and polyfluoroalkyl substances (PFAS) on thyroid homeostasis. However, most studies focused on individual thyroid hormones.

Objective: To explore the associations between PFAS exposures and thyroid homeostasis parameters.

Molecular classification and adjuvant treatment in endometrioid endometrial cancer with microcystic elongated and fragmented (MELF) invasion pattern.

Objective: To assess the characteristics, molecular classification, and role of adjuvant treatment in patients with endometrioid endometrial cancer (EEC) and microcystic elongated and fragmented (MELF) myometrial invasion pattern.

Methods: This study included patients who were diagnosed with EEC with a MELF invasion pattern and underwent surgery from January 2019 to December 2023. We analyzed molecular classification, clinicopathological characteristics, and prognostic outcomes, including recurrence and adjuvant therapy.

Molecular characterization and B-cell epitope analysis of the TSP11 gene in infection strains from Yunnan Province.

This study investigates the molecular intricacies of the transmembrane protein TSP11 gene in strains isolated from livestock and patients in Yunnan Province afflicted with between 2016 and 2020. Gene typing analysis of the ND1 gene revealed the presence of the G1 type, G5 type and untyped strains, constituting 52.4, 38.

"Tension band wiring first" -an easy, fast and reproducible technique to reduce patellar fractures, a retrospective comparative study with traditional reduction technique.

Objective: To evaluate intraoperative and early postoperative clinical outcomes using the "tension band wiring first technique" to reduce C type patellar fractures.

Methods: Sixty-four patients with C type fractures were enrolled in this study. Thirty-four patients underwent open reduction and internal fixation (ORIF) surgeries using the traditional reduction technique by pointed clamps (TRT group).

Regulation of nucleation and crystallization for blade-coating large-area CsPbBr perovskite light-emitting diodes.

Metal halide perovskite light-emitting diodes (PeLEDs) and large-area perovskite color conversion layers for liquid crystal display exhibit great potential in the field of illumination and display. Blade-coating method stands out as a highly suitable technique for fabricating large-scale films, albeit with challenges such as uneven nucleation coverage and non-uniformity crystallization process. In this work, we developed an in-situ characterization measurement system to monitor the perovskite nucleation, and crystallization process.

The characteristics and mechanism of NaHCO compound fly ash in suppressing gas explosions in pipeline networks.

Gas has been widely concerned due to its importance in the industrial and energy fields. In order to improve the inhibition effect of gas explosion, under the self-constructed pipe network system, the inhibition of gas explosion by composite inhibitor of fly ash and NaHCO with different ratios was investigated, and the microscopic inhibition mechanism of the two kinds of powders on the explosion of gas was investigated based on the method of density functional theory and transition state theory from the perspective of molecular dynamics. The results show that: the composite powder explosion suppression is better than a single powder, explosion suppression effect with the increase in the proportion of the mass of NaHCO significantly improve the 5 groups of conditions NaHCO loading of 40% (by mass) is the best, this time, the explosion of the peak overpressure, the peak flame propagation velocity, the peak flame temperature compared to the maximum reduction in the percentage of the measures taken for the maximum of 74.

MiR-192 and miR-731 synergically inhibit RGNNV infection by targeting ULK1-mediated autophagy in sea perch (Lateolabrax japonicus).

MicroRNAs (miRNAs) are crucial regulators of gene expression and are closely linked to viral infections. Nervous necrosis virus (NNV) poses a significant threat to global fish aquaculture. This study investigates the roles of miR-192 and miR-731 in controlling NNV infection and associated autophagy in sea perch (Lateolabrax japonicus).

Ecohydrological changes recorded by sedimentary diatoms in the Dajiuhu Wetland in Shennongjia over the past 40 years.

Anthropogenic hydrological regulation is profoundly altering the structure and function of wetland ecosystems. Due to the scarcity of long-term monitoring records, the responses of wetland ecosystems to anthropogenic hydrological regulation remain unclear. We reconstructed past ecohydrological changes in Dajiuhu Wetland during the last 40 years and explored the driving forces, based on multiproxy records of a 44-cm-length sediment core collected from Wuhaohu Lake of Dajiuhu Wetland in Shennongjia, Hubei.

Synaptic Feature of Quantum Dot Light-Emitting Diodes for Visualization of Learning Process.

Brain-inspired electronics with synaptic functions hold significant promise for advancing artificial intelligent applications. In this study, we demonstrate the synaptic feature of quantum-dot light-emitting diodes (QLEDs), which can convert electrical pulses into synapse-like light signals (the brightness gradually increases as the electrical pulses are prolonged). These features are analogous to learning and forgetting in biological synapses.

MSIsensor-RNA: Microsatellite Instability Detection for Bulk and Single-cell Gene Expression Data.

Microsatellite instability (MSI) is an indispensable biomarker in cancer immunotherapy. Currently, MSI scoring methods by high-throughput omics methods have gained popularity and demonstrated better performance than the gold standard method for MSI detection. However, the MSI detection method on expression data, especially single-cell expression data, is still lacking, limiting the scope of clinical application and prohibiting the investigation of MSI at a single-cell level.

Texture analysis based on CT for predicting the differentiation of esophageal squamous cancer: An observational study.

To explore the feasibility and application value of texture analysis based on computed tomography (CT) for predicting the differentiation of esophageal squamous cell carcinoma (ESCC). Patients diagnosed with ESCC who underwent chest contrast-enhanced CT before treatment were selected. Based on the pathological results, the patients were stratified into poorly differentiated and moderately well-differentiated groups.