Targeting sirtuins in neurological disorders: A comprehensive review.

The sirtuin (SIRT) family is a group of seven conserved nicotinamide adenine dinucleotide-dependent histone deacetylases (SIRT1-SIRT7), which play crucial roles in various fundamental biological processes, including metabolism, aging, stress responses, inflammation, and cell survival. The role of SIRTs in neuro-pathophysiology has recently attracted significant attention. Notably, SIRT1-SIRT3 have been identified as key players in neuroprotection as they reduce neuroinflammation and regulate mitochondrial function.

Evaluation of SI, MSI and DSI for very early (3-day) mortality in patients with septic shock.

Background: Septic shock is associated with increased mortality. Predicting mortality, including early prediction for septic shock patients in intensive care units (ICUs), remains an important challenge.

Method: We searched the Medical Information Mart for Intensive Care IV database.

Occurrence of Pratylenchus coffeae Causing Root Rot of Soybean in Shandong Province of China.

Soybean (Glycine max L.) is a very important commercial crop in China (Li et al. 2019).

Optimization of multi-angle Magneto-Acousto-Electrical Tomography (MAET) based on a numerical method.

Magneto-Acousto-Electrical Tomography (MAET) is a novel multi-physics imaging method, which promises to offer a unique biophysical property of tissue electrical impedance with the additional benefit of excellent spatial resolution of the ultrasonic imaging. It opens the potential for early diagnosis of cancer by revealing changes of dielectric characteristics. However, direct MAET is unable to image the irregularly-shaped lesions fully due to the dependence on the angle between conductivity boundary and ultrasound beam direction.