A Composite Index for Distinguishing Benign and Malignant Obstructive Jaundice.

Objective: To explore a more effective and practical comprehensive index for differentiating benign from malignant obstructive jaundice by analyzing the clinical data of patients with benign obstructive jaundice (BJ) group and malignant obstructive jaundice (MJ) group.

Methods: A retrospective analysis was conducted on the clinical data of 339 patients with obstructive jaundice. The cases were divided into two data sets: training cohort and validation cohort.

Plasma fibroblast growth factor 21 and risk of cognitive impairment among patients with ischemic stroke.

Background And Aims: Previous study reported that plasma fibroblast growth factor 21 (FGF-21) was associated with poor prognosis in patients with ischemic stroke. The purpose of present study was to prospectively investigate the relationship between plasma FGF-21 and post-stroke cognitive impairment (PSCI).

Methods: A total of 600 patients from 7 hospitals were included in this study and plasma FGF-21 levels were examined for all the participants.

Partial unidirectional translocation from 5AL to 7BS leads to dense spike in an EMS-induced wheat mutant.

Background: As the inflorescence of wheat, spike architecture largely determines grain productivity. Dissecting the genetic basis for the spike morphology of wheat can contribute to the designation of ideal spike morphology to improve grain production.

Results: The present study characterizes a dense spike1 (ds1) mutant, derived from Nongda3753, induced by EMS treatment, which exhibits a dense spike and reduced plant height.

Neonatal lupus erythematosus successfully treated by exchange transfusion: a case report and literature review.

Introduction: There are few reports of severe hematological involvement in children with neonatal lupus erythematosus (NLE) treated with exchange transfusion. In this case report, we present a female patient with NLE admitted to the Children's Hospital of Soochow University. The main clinical manifestations were pancytopenia and congenital heart block (CHB).

Dimdazenil for the treatment of insomnia: a systematic review and narrative synthesis.

Background: Insomnia is a common sleep disorder affecting approximately 10-20% of adults worldwide. Despite various available treatment modalities, significant gaps remain in improving sleep maintenance and reducing functional impairments.

Objective: To systematically review and synthesize studies on the efficacy and safety of Dimdazenil for the treatment of insomnia.

ICOS-expressing CAR-T cells mediate durable eradication of triple-negative breast cancer and metastasis.

Background: The failure of conventional therapies and the propensity for recurrence and metastasis make triple-negative breast cancer (TNBC) a formidable challenge with grim prognoses and diminished survival rates. Immunotherapy, including immune checkpoint blockade and chimeric antigen receptor (CAR)-T cell therapy, presents innovative and potentially more effective strategies for addressing TNBC. Within this context, the inducible costimulator (ICOS), a member of the CTLA4/CD28 family, plays a crucial role in regulating immune responses and T-cell differentiation by binding to its ligand ICOSL.

Potassium ion channel modulation at cancer-neural interface enhances neuronal excitability in epileptogenic glioblastoma multiforme.

The central nervous system (CNS) is increasingly recognized as a critical modulator in the oncogenesis of glioblastoma multiforme (GBM), with interactions between cancer and local neuronal circuits frequently leading to epilepsy; however, the relative contributions of these factors remain unclear. Here, we report a coordinated intratumor shift among distinct cancer subtypes within progenitor-like families of epileptic GBM patients, revealing an accumulation of oligodendrocyte progenitor (OPC)-like subpopulations at the cancer-neuron interface along with heightened electrical signaling activity in the surrounding neuronal networks. The OPC-like cells associated with epilepsy express KCND2, which encodes the voltage-gated K channel K4.

Nano-micro materials regulated biocatalytic metabolism for efficient environmental remediation: Fine engineering the mass and electron transfer in multicellular environments.

The escalating energy and environmental crises have spurred significant research interest into developing efficient biological remediation technologies for sustainable contaminant and resource conversion. Integrating engineered nano-micro materials (NMMs) with these biocatalytic processes offers a promising approach to improve the microbial performance for environmental remediation. Core to such material-enhanced hybrid biocatalysis systems (MHBSs) is the rational regulation of metabolic processes with the assistance of NMMs, where a fine engineered mass and electron transfer is beneficial for the improved biocatalytic activity.

Head-to-head study of [F]FAPI-04 PET/CT and [F]FDG PET/CT for non-invasive assessment of liver cancer and its immunohistochemical markers.

Objective: To compare the performance of [F]FDG and [F]FAPI-04 in PET/CT evaluation for liver cancer lesions, with a further exploration of the associations between PET semiquantitative data and immunohistochemical markers to liver cancer.

Methods: Patients with suspected malignant liver lesions (MLL) underwent [F]FDG and [F]FAPI-04 PET/CT scanning. Liver lesions were visually classified as positive or negative based on their uptake level exceeding that of adjacent normal liver tissue.

Metformin inhibits migration and epithelial-to-mesenchymal transition in non-small cell lung cancer cells through AMPK-mediated GDF15 induction.

The growth differentiation factor 15 (GDF15) may serve as a biomarker of metformin, which mediates the bodyweight lowering effect of metformin. However, whether GDF15 also serves as a molecular target of metformin to inhibit carcinogenesis remains largely unknown. This study examined the role and molecular mechanisms of GDF15 in the anticancer effects of metformin in non-small cell lung cancer (NSCLC) cells, which has never been reported before.

GPCR-like Protein ZmCOLD1 Regulate Plant Height in an ABA Manner.

G protein-coupled receptors (GPCRs) are sensors for the G protein complex to sense changes in environmental factors and molecular switches for G protein complex signal transduction. In this study, the homologous gene of GPCR-like proteins was identified from maize and named as ZmCOLD1. Subcellular analysis showed that the ZmCOLD1 protein is localized to the cell membrane and endoplasmic reticulum.

Preparation and Properties of NaHPO∙12HO/Silica Aerogel Composite Phase Change Materials for Building Energy Conservation.

In this paper, a morphologically stable composite phase change material (CPCM) suitable for use in the field of building energy conservation was developed using NaHPO∙12HO (DHPD) as the phase change material, NaSiO∙9HO (SSNH) as the nucleating agent, and silica aerogel (SA) as the carrier. The results showed that the incorporation of 25 wt% SA resulted in the as-prepared DHPD-SSNH/SA CPCM with a phase change temperature of 30.4 °C, an enthalpy of 163.

Microwell-assembled aluminum substrates for enhanced single-cell analysis: A novel approach for cancer cell profiling by Raman spectroscopy.

Single-cell analysis is critical for advancing personalized medicine, as it reveals cell population heterogeneity that influences disease outcomes. We present a microwell-assembled aluminum substrate platform that enhances single-cell Raman spectroscopy in liquid suspension by isolating individual cells and preventing stacking and movement, which significantly improves signal stability and the signal-to-noise ratio (SNR). We applied this novel platform to analyze PC-9 lung cancer cells and BEAS-2B normal bronchial epithelial cells, identifying distinct biochemical differences.

Transforming pediatric heart failure: Efficacy of low-dose sacubitril/valsartan.

Aims: Pediatric heart failure is a significant cause of illness and death in children. We aimed to assess sacubitril/valsartan's effectiveness and find the proper dosage for pediatric patients.

Methods: Patients unresponsive to traditional medicines for at least 12 months prescribed sacubitril/valsartan from January 2020 to March 2023 were reviewed.

Acyclovir contamination in environment: Occurrence, transformation, toxicity, risk, and evaluation as a pharmaceutical indicator.

Acyclovir (ACV), a widely used antiviral medication effective against herpes simplex viruses (HSV), is raising concern due to its pervasive presence in global water and the associated potential risks. ACV can undergo transformation under varying conditions, leading to the generation of diverse transformation products that may exhibit heightened toxicity. This review aims to present a comprehensive overview of the environmental impact of ACV.

Innovative use of radial artery retrograde forearm flap for oral and maxillofacial reconstruction.

Introduction: The purpose of this study is to present a novel method of reconstructing oral and maxillofacial defects using the Radial Artery Retrograde Proximal Forearm Flap (RARPFF) and to evaluate the efficacy and safety of the forearm flap for direct closure of the donor site and its effect on hand function in the donor area.

Methods: A prospective study of 30 patients who underwent oral and maxillofacial reconstruction with RARPFF between June 2021 and April 2024 was conducted to evaluate the safety and efficacy of the flap and its influence on hand function in the donor area.

Results: Flap survival was 93.

Tetrabutylammonium Hydroxide-Functionalized TiCT MXene for Significantly Improving the Photovoltaic Performance of Perovskite Solar Cells.

An appropriate electron transport layer (ETL) or cathode buffer layer (CBL) is critical for high-performance perovskite solar cells (PVSCs). In this work, tetrabutylammonium hydroxide (TBAOH)-functionalized TiCT MXene (TBAOH-TiCT) is developed to improve the photovoltaic performance of PVSCs. TBAOH-TiCT is synthesized by HF etching and then TBAOH intercalation, and TBAOH can effectively attach to the TiCT surface during the intercalation process.