[Early diagnosis and intervention for prepubertal short stature children].

The prevalence of short stature among prepubertal children in China is relatively high. Early identification of the cause and timely intervention can bring greater benefits to children with short stature. This paper provides an overview of early diagnosis, intervention measures, and personalized medication dosage for prepubertal short stature children, aiming to provide references for clinical doctors.

Assessing size shifts amidst a warming climate in lakes recharged by the Asian Water Tower through satellite imagery.

Recent studies indicate that the Asian Water Tower (AWT) is at risk due to climate change, which can negatively impact water and food security in Asia. However, there is a lack of comprehensive information on lakes' spatial and temporal changes in this region. This information is crucial for understanding the risk magnitude and designing strategies.

Spatiotemporal distribution characteristics of ecosystem health and the synergetic impact of its driving factors in the Yangtze River Delta, China.

In recent years, . the rapid development of the Yangtze River Delta in China has led to increasingly serious regional eco-environmental problems. Therefore, it is of great significance for the construction of ecological civilization to study the ecosystem health in the Yangtze River Delta.

Reconstruction of all-weather land surface temperature based on a combined physical and data-driven model.

At present, the remote sensing (RS) thermal infrared (TIR) images that are commonly used to obtain land surface temperature (LST) are contaminated by clouds and thus cannot obtain spatiotemporal integrity of LST. To solve this problem, this study combined a physical model with strong interpretability with a data-driven model with high data adaptability. First, the physical model (Weather Research and Forecast (WRF) model) was used to generate LST source data.

Clinical evaluation, accurate diagnosis and treatment of four pedigrees with Fabry's disease.

Objective: This article analyzes the data of four families with mutations of the GLA (galactosidase) gene with a special focus on the clinical presentation, diagnosis, and interdisciplinary clinical management of Fabry disease (FD) and enzyme replacement therapy (ERT) treatment, and has the aim to assess more accurate prevention and treatment strategy.

Methods: The MSSI (Mainz Severity Score Index) scale was used to evaluate the clinical data of five children diagnosed in our hospital, and the genotypes of all the patients with FD were collected. Two of the male children started ERT.

Effect of rainfall-runoff process on sources and transformations of nitrate using a combined approach of dual isotopes, hydrochemical and Bayesian model in the Dagang River basin.

The control of agricultural nitrogen through inflow rivers is crucial for lake aquatic environment conservation, while nitrate is the main form of non-point source pollution of agricultural nitrogen in watersheds. Therefore, understanding the nitrate sources and transformation in the intensive-agricultural region was particularly concerned. Nitrate sources and transformation varied largely during some crucial periods or events.

A Real-World Study of Recombinant Human Growth Hormone in the Treatment of Idiopathic Short Stature and Growth Hormone Deficiency.

Objective: This study aimed to evaluate the clinical efficacy of recombinant human growth hormone (rhGH) in the treatment of children with idiopathic short stature (ISS) and growth hormone deficiency (GHD) and to explore the related factors affecting treatment efficacy.

Methods: The current research reflects a real-world study. A total of 79 patients with ISS and 95 patients with GHD (both groups pre-puberty) who had been treated with rhGH for more than one year from January 2010 to September 2019 were included in this study.

Clinical and genetic characteristics of two cases with Williams-Beuren syndrome.

Herein, we describe 2 cases of Williams-Beuren syndrome (WBS). In both cases, the patients exhibited mental retardation, characteristic facial features, and indirect inguinal hernia. Case 1, a girl aged 2 years and 5 months old, presented with hypercalcemia, and in case 2, a boy aged 4 years and 11 months old, the disorder manifested as infantile spasms, supravalvular aortic stenosis, and pulmonary stenosis.

SS-31 Protects Liver from Ischemia-Reperfusion Injury via Modulating Macrophage Polarization.

Ischemia-reperfusion injury (IRI) is a common complication in liver surgeries. It is a focus to discover effective treatments to reduce ischemia-reperfusion injury. Previous studies show that oxidative stress and inflammation response contribute to the liver damage during IRI.

Elevated HMGB1 expression induced by hepatitis B virus X protein promotes epithelial-mesenchymal transition and angiogenesis through STAT3/miR-34a/NF-κB in primary liver cancer.

HBV infection plays a crucial role in primary liver cancer development. Also, HBV related liver cancer has higher invasiveness and earlier discovered distant metastasis. HBV-encoded X protein (HBx) exerts various biological functions on liver cancer progression, including proliferation, invasion, and venous metastasis.

Hybrid perfect metamaterial absorber for microwave spin rectification applications.

Metamaterials provide compelling capabilities to manipulate electromagnetic waves beyond the natural materials and can dramatically enhance both their electric and magnetic fields. The enhanced magnetic fields, however, are far less utilized than the electric counterparts, despite their great potential in spintronics. In this work, we propose and experimentally demonstrate a hybrid perfect metamaterial absorbers which combine the artificial metal/insulator/metal (MIM) metamaterial with the natural ferromagnetic material permalloy (Py) and realize remarkably larger spin rectification effect.

Protective Properties of FOXO1 Inhibition in a Murine Model of Non-alcoholic Fatty Liver Disease Are Associated With Attenuation of ER Stress and Necroptosis.

Aim: The pathogenesis of non-alcoholic fatty liver disease is currently unclear, however, lipid accumulation leading to endoplasmic reticulum stress appears to be pivotal in the process. At present, FOXO1 is known to be involved in NAFLD progression. The relationship between necroptosis and non-alcoholic steatohepatitis has been of great research interest more recently.

[Clinical and genetic analysis of two cases with Rubinstein-Taybi syndrome].

Objective: To summarize the clinical characteristics and identify gene mutations of 2 probands with Rubinstein-Taybi syndrome (RSTS).

Methods: Clinical characteristics of 2 probands with Rubinstein-Taybi syndrome were summarized. Genomic DNA was extracted from peripheral blood samples from the patients and their parents.

A Newborn with Congenital Hyperinsulinism.

Our aim was to describe the molecular alterations in the ABCC8 gene in a child with congenital hyperinsulinism (CHI). Genetic analysis of the ABCC8 gene of a newborn infant with congenial hyperinsulinism was obtained. There were two mutations in the ABCC8 gene, c.

Two Chinese Xia-Gibbs syndrome patients with partial growth hormone deficiency.

Background: Heterozygous mutations in the AT-hook DNA-binding motif containing one (AHDC1, OMIM * 615790) gene cause an autosomal dominant multisystem developmental disorder known as Xia-Gibbs syndrome (OMIM #615829). Xia-Gibbs syndrome typically presented with global developmental delay, hypotonia, obstructive sleep apnea, seizures, delayed myelination, micrognathia, and other mild dysmorphic features.

Methods: Description of the clinical materials of two Chinese boys who were diagnosed with Xia-Gibbs syndrome based on clinical presentations and next generation sequencing.

Dramatically Enhanced Spin Dynamo with Plasmonic Diabolo Cavity.

The applications of spin dynamos, which could potentially power complex nanoscopic devices, have so far been limited owing to their extremely low energy conversion efficiencies. Here, we present a unique plasmonic diabolo cavity (PDC) that dramatically improves the spin rectification signal (enhancement of more than three orders of magnitude) under microwave excitation; further, it enables an energy conversion efficiency of up to ~0.69 mV/mW, compared with ~0.

Metamaterial perfect absorbers with solid and inverse periodic cross structures for optoelectronic applications.

Metamaterial based on a metal/insulator/metal (MIM) tri-layer structure provides an agile platform to realize high absorption efficiency for a variety of applications including semiconductor optoelectronic detectors. In this work, we use the finite time domain difference (FDTD) method and coupled mode theory (CMT) to numerically study metal/semiconductor/metal (MSM) structures and discuss their effective absorption for optoelectronic application. We compare MSM structures with a different top metal layer design and find that cross shaped absorber (CSA) and it's complementary cross shaped absorber (CCSA) exhibit different phase diagrams due to a distinctive dependence of radiation loss on geometrical parameters.

Design of triple-band metamaterial absorbers with refractive index sensitivity at infrared frequencies.

A triple-band perfect plasmonic metamaterial absorber based on a metal/insulator/metal (MIM) structure is designed. A new freedom through tuning the thicknesses of each ring structures is introduced to realize a quasi-three-dimensional perfect absorber at three extinction wavelengths by using the finite difference time domain method. The physical machine is explained by the time domain field analyses and the coupled mode theory.

Plasmonic focusing of infrared SNOM tip patterned with asymmetric structures.

Several scattering type metal tips patterned with asymmetric metal/dielectric bump gratings are studied and proved to be efficient in focusing light energy into nano 'hot spot'. The dielectric bump tip shows complex mechanisms including local geometric resonance, surface plasmon polariton (SPP) standing wave resonance and Fano effect in the near-field enhancement. Additionally, considering the practical situation, we also demonstrate that, for the case of bending tip surface, the grating coupling method for plasmonic nano-focusing is still applicable if the intervals between neighboring bumps are well designed according to the surface bending curvature.