Publications by authors named "Peng Gong"

Background: The introduction of the Enterovirus A71 (EV-A71) vaccine in China in 2016 has led to a considerable decline in severe hand, foot, and mouth disease (HFMD) cases, with mild outpatient instances now representing the majority of HFMD cases in the country. Nevertheless, epidemiological investigations concerning mild outpatient cases remain scarce, resulting in inadequate descriptions of their clinical, etiological, and epidemiological characteristics. Our study aimed to analyze the clinical, etiological, and epidemiological characteristics of HFMD outpatients in Chengdu from 2019 to 2022 while identifying potential risk factors associated with the progression of outpatients requiring hospitalization.

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Urban building height, as a fundamental 3D urban structural feature, has far-reaching applications. However, creating readily available datasets of recent urban building heights with fine spatial resolutions and global coverage remains a challenging task. Here, we provide a 150-m global urban building heights dataset around 2020 by combining the spaceborne lidar (Global Ecosystem Dynamics Investigation, GEDI), multi-sourced data (Landsat-8, Sentinel-2, and Sentinel-1), and topographic data.

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  • ATR signaling is crucial for detecting and responding to replication stress in cells, and defects in this process can harm cellular function and survival.
  • FOXP1, a transcription factor, not only helps activate ATR but also acts as a scaffold to connect components like RPA-ssDNA and ATR-ATRIP, enhancing ATR recruitment and activation.
  • The regulation of FOXP1's activity involves O-GlcNAcylation and CHK1-mediated phosphorylation, and mutations in FOXP1 found in tumors can weaken ATR activation, suggesting that targeting FOXP1 could be a potential strategy for cancer treatment.
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  • The world is nearing the critical threshold of 1.5°C warming, with 2023 recording an average temperature rise of 1.45°C since pre-industrial times, leading to severe climate-related impacts.
  • The Countdown collaboration, formed to assess the health impacts of climate change post-Paris Agreement, involves over 300 experts analyzing data and trends annually.
  • The 2024 report highlights troubling increases in climate-related health risks, such as a staggering 167% rise in heat-related deaths among seniors, indicating worsening conditions affecting wellbeing globally.
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  • Qingshen granule (QSG) has anti-inflammatory and immunoregulatory properties that can help alleviate renal damage caused by renal fibrosis (RF), particularly by affecting dendritic cells (DCs).
  • The study used adenine-induced RF animal models to assess how QSG influences immune cell differentiation and function, alongside examining its metabolic effects on glucose and lipid processes in DCs and T cells.
  • Results showed that QSG reduced kidney damage, lowered proinflammatory cytokines, altered DC markers, and impacted metabolic gene expression, ultimately promoting DC maturation while inhibiting their migratory ability and antigen presentation to T cells.
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  • - Extreme precipitation events, defined as days with rainfall exceeding the county-specific 99.5th percentile, were studied for their impact on deaths in 280 Chinese counties from 1986 to 2005, showing significant associations with various causes of death. - The study projected future excess deaths related to extreme precipitation using different climate scenarios (RCP2.6, RCP4.5, RCP8.5) and socioeconomic contexts, estimating increases in deaths due to accidental causes, circulatory diseases, and respiratory diseases by the 2030s. - Specifically, the analysis found that annual average excess deaths associated with extreme precipitation events were significant, with substantial increases projected under moderate and high-emission scenarios, highlighting the urgency of addressing climate change
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Background: Bufalin (BA) is a potent traditional Chinese medicine derived from toad venom. It has shown significant antitumor activity, but its use is limited by cardiotoxicity, which necessitates innovative delivery methods, such as rod-shaped mesoporous silica nanoparticles (rMSNs). rMSNs have been extensively employed for reducing drug toxicity and for controlled or targeted drug delivery in tumor therapy.

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We aimed to investigate the effect of a polysaccharide from Tremella aurantialba on ulcerative colitis (UC), which targets ferroptosis in epithelial cells. TA 2-1 (127 kDa) was isolated from T. aurantialba and consisted of Man, Xyl, GlcA, Glc, Fuc and Rha with a molar ratio of 59.

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East Asian herbivorous waterfowl intensively use farmland in spring, next to their natural habitat. Accordingly, they might have expanded their migration strategy from merely tracking the green wave of newly emerging vegetation to also incorporating the availability of post-harvest agricultural seeds (here dubbed the seed wave). However, if and how waterfowl use multiple food resources to time their seasonal migration is still unknown.

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Hydrogen is regarded as one of the most promising clean substitutes for fossil fuels toward a carbon-zero society. However, the safety management of the upcoming hydrogen energy infrastructure has not been fully prepared, in contrast to the well-established natural gas and gasoline systems. On the frontline is the guard post of hydrogen detectors, which need to be deployed on various structural surfaces and environmental conditions.

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Aquatic vegetation is crucial for improving water quality, supporting fisheries and preserving biodiversity in lakes. Monitoring the spatiotemporal dynamics of aquatic vegetation is indispensable for the assessment and protection of lake ecosystems. Nevertheless, a comprehensive global assessment of lacustrine aquatic vegetation is lacking.

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Objective: Hepatocellular carcinoma, characterized by high mortality rates, often exhibits limited responsiveness to conventional treatments such as surgery, radiotherapy, and chemotherapy. Therefore, identifying a sensitizer for cisplatin has become crucial. Dihydroartemisinin, known for its potent role of tumor treatment, arises as a prospective candidate for cisplatin sensitization in clinical settings.

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  • Researchers studied how genetic factors influence the behavior of vascular smooth muscle cells (VSMCs) in processes like apoptosis, using samples from over 2000 individuals.
  • While they found no significant links to VSMC proliferation or migration, two specific genetic loci were associated with increased VSMC apoptosis.
  • The study highlighted the relationship between the genes GSDME and PALS2, suggesting that manipulating these genes could lead to new therapies targeting VSMC apoptosis.
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  • - Neuroendocrine neoplasms (NENs) are diverse tumors that originate from neuroendocrine cells, with gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) being the most common type.
  • - Recent studies show that GEP-NENs are becoming more prevalent and may have a more aggressive nature than previously thought, leading to limited life expectancy for patients.
  • - The review highlights the need for improved research on diagnosis and management of GEP-NENs, addressing current limitations in understanding their epidemiology, clinical features, and treatments.
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Influenza viruses and thogotoviruses account for most recognized orthomyxoviruses. Thogotoviruses, exemplified by Thogoto virus (THOV), are capable of infecting humans using ticks as vectors. THOV transcribes mRNA without the extraneous 5' end sequences derived from cap-snatching in influenza virus mRNA.

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Sepsis is an infection-triggered, rapidly progressive systemic inflammatory syndrome with a high mortality rate. Currently, there are no promising therapeutic strategies for managing this disease in the clinic. Heparanase plays a crucial role in the pathology of sepsis, and its inhibition can significantly relieve related symptoms.

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In high-resolution remote sensing images (RSIs), complex composite object detection (e.g., coal-fired power plant detection and harbor detection) is challenging due to multiple discrete parts with variable layouts leading to complex weak inter-relationship and blurred boundaries, instead of a clearly defined single object.

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Nighttime light remote sensing has been an increasingly important proxy for human activities. Despite an urgent need for long-term products and pilot explorations in synthesizing them, the publicly available long-term products are limited. A Night-Time Light convolutional LSTM network is proposed and applied the network to produce a 1-km annual Prolonged Artificial Nighttime-light DAtaset of China (PANDA-China) from 1984 to 2020.

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Urban park green spaces (UPGS) are a crucial element of social public resources closely related to the health and well-being of urban residents, and issues of equity have always been a focal point of concern. This study takes the downtown area of Nanchang as an example and uses more accurate point of interest (POI) and area of interest (AOI) data as analysis sources. The improved Gaussian two-step floating catchment area (G2SFCA) and spatial autocorrelation models are then used to assess the spatial and social equity in the study area, and the results of the two assessments were coupled to determine the optimization objective using the community as the smallest unit.

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The role of tropical forests in the global carbon budget remains controversial, as carbon emissions from deforestation are highly uncertain. This high uncertainty arises from the use of either fixed forest carbon stock density or maps generated from satellite-based optical reflectance with limited sensitivity to biomass to generate accurate estimates of emissions from deforestation. New space missions aiming to accurately map the carbon stock density rely on direct measurements of the spatial structures of forests using lidar and radar.

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This study aimed to investigate the molecular mechanism of the effect of PDCD4 on radiotherapy-induced acute kidney injury (AKI) in rectal cancer through the regulation of FGR/NF-κB signaling. Differentially expressed genes were identified using Gene Expression Omnibus (GEO) datasets (GSE90627 for rectal cancer and GSE145085 for AKI) and R software. The human renal tubular epithelial cell line, HK-2, was used to establish an in vitro model of radiotherapy-induced AKI.

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