Dibohemamines I-O from Streptomyces sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Houttuynia cordata Thunb.

A chemical investigation of Streptomyces sp. GZWMJZ-662, an endophytic actinomycete isolated from Houttuynia cordata Thunb., has yielded eleven bohemamine dimers (1-11).

Sustainable superhydrophobic lignin-based polyurethane foam: an innovative solution for oil pollutant adsorption.

Green, efficient treatment of crude oil spills and oil pollutants is a global challenge, with adsorption technology favored for its efficiency and low environmental impact. The development of an environmentally friendly adsorbent with high hydrophobicity, excellent adsorption performance, and degradability is crucial to overcoming the limitations of petroleum-based adsorbents. Here, a lignin-based polyurethane foam (LPUF) with superhydrophobic and photothermal oil-absorbing properties was fabricated by incorporating octadecyltrimethoxysilane into the foam system.

Spatial transcriptomics in breast cancer: providing insight into tumor heterogeneity and promoting individualized therapy.

A comprehensive understanding of tumor heterogeneity, tumor microenvironment and the mechanisms of drug resistance is fundamental to advancing breast cancer research. While single-cell RNA sequencing has resolved the issue of "temporal dynamic expression" of genes at the single-cell level, the lack of spatial information still prevents us from gaining a comprehensive understanding of breast cancer. The introduction and application of spatial transcriptomics addresses this limitation.

Semisynthesis of Nocarterphenyl A and Its Analogues.

-Terphenyl compounds are known to possess a diverse range of biological activities, making the synthesis of novel -terphenyl derivatives a significant research objective. In this study, we report the first synthesis of nocarterphenyl A (), characterized by a thiazole-fused -terphenyl framework. Furthermore, we synthesized 18 additional analogs, including the naturally occurring compound 5-methoxy-4,7-bis(4-methoxyphenyl)benzo[]thiazol-6-ol (), employing a similar synthetic approach.

Whole transcriptome and proteome analyses identify ncRNAs and mRNAs to predict competing endogenous RNA networks in hepatitis B virus-induced hepatocellular carcinoma.

The presence of the Hepatitis B virus (HBV) is considered as a valuable risk factor of hepatocellular carcinoma (HCC). To more deeply comprehend the molecular mechanism and transcriptome of HBV-induced HCC, we utilized tandem mass tagging (TMT)-based quantitative proteomics analysis and whole-transcriptome sequencing to analyze three sets of matched HepG2 hepatoma cells and HBV-positive HepAD38 cells. The differentially expressed (DE) proteins (1596), mRNAs (5263), miRNAs (581), lncRNAs (2672) and circRNAs (222) were subjected to differential expression and enrichment analyses in order to thoroughly assess the gene-regulatory circuits of HBV-induced HCC.

Novel decision-level fusion strategies combined with hyperspectral imaging for the detection of soybean protein content.

Soybeans are used for human consumption or animal feed due to their abundant protein content. In this study, visible-near infrared (VNIR) hyperspectral imaging (HSI) and short-wave infrared HSI combined with three-levels data fusion methods were employed to detect the protein content of soybean seeds, including measurement-level fusion, feature-level fusion, and decision-level fusion. Additionally, three novel decision-level fusion methods were proposed, including binary linear regression, feature-based multiple linear regression (MLR), and model-based MLR.

Biogenic iron mineral formation and the fate of arsenic driven by its coupling with ferrous iron in acid mine drainage environment.

Acid mine drainage (AMD) containing arsenic produced during coal mining is a global environmental problem. However, the coupled driving process of the key element Fe and the associated element As in the AMD environment has received little attention. Therefore, in this study, we investigated the A.

The diagnostic and prognostic value of heparin-binding protein in cerebrospinal fluid for patients with intracranial infections.

Background: This study aims to evaluate the diagnostic and prognostic value of heparin-binding protein (HBP) in cerebrospinal fluid (CSF) for patients with intracranial infections.

Methods: This study included 211 subjects, of whom 138 were diagnosed with intracranial infections, 20 were patients with non-infectious inflammatory encephalopathies, and 53 controls who were eventually excluded from intracranial infections and inflammatory encephalopathies. The levels of HBP and procalcitonin (PCT) in CSF were detected in the subjects, and the diagnostic value of CSF HBP and PCT for intracranial infections was assessed using the receiver operating characteristic (ROC) curves.

Amino-Based Probe for Natural Products with Covalent Binding Ability to Lysine and Mechanism of Action of Medermycin.

A chemoselective amino-based probe was designed for discovering natural products with covalent binding potential to lysine. Using this reactivity-based technique, a marine-derived strain was identified, which could produce medermycin as the major metabolite. A new compound, mederpyrrole A, derived from medermycin and anthranilic acid through nonenzymatic reaction was isolated.

Lycium barbarum oligosaccharide-derived carbon quantum dots inhibit glial scar formation while promoting neuronal differentiation of neural stem cells.

Overexpression of glial fibrillary acidic protein (GFAP) in activated astrocytes following spinal cord injury is closely associated with glial scar formation, which harms axonal regrowth. In this study, we prepared ultrasmall cationic carbon quantum dots (CQDs) via one-step hydrothermal carbonization. Lycium barbarum oligosaccharides were used as the carbon source for the first time, and polyetherimide (PEI) and ethylenediamine (ED) were used as cationic reagents.

Cell components of tumor microenvironment in lung adenocarcinoma: Promising targets for small-molecule compounds.

Lung cancer is one of the most lethal tumors in the world with a 5-year overall survival rate of less than 20%, mainly including lung adenocarcinoma (LUAD). Tumor microenvironment (TME) has become a new research focus in the treatment of lung cancer. The TME is heterogeneous in composition and consists of cellular components, growth factors, proteases, and extracellular matrix.

Blestriarene C exerts an inhibitory effect on triple-negative breast cancer through multiple signaling pathways.

Introduction: Breast cancer is the most common cancer worldwide, the leading cause of cancer death in women, and the fifth leading cause of cancer death. Triple negative breast cancer (TNBC), with high metastasis and mortality rates, is the most challenging subtype in breast cancer treatment. There is an urgent need to develop anti-TNBC drugs with significant efficacy, low side effects and good availability.

Associations of gestational thyrotropin levels with disease progression among pregnant women with differentiated thyroid cancer: a retrospective cohort study.

Purpose: Pregnant women with a diagnosis of differentiated thyroid cancer (DTC) were potentially high-risk but largely ignored study population. We aimed to explore whether gestational thyrotropin levels were associated with progression of DTC.

Methods: We conducted a retrospective cohort study at Peking University Third Hospital in Beijing, China from January 2012 to December 2022.

Controllable self-assembly of double polyphenol-metal-network: A universal gravel-like lignin catalysts for water purification.

Lignin has attracted wide attention in sustainable environment remediation, especially the polyphenol-metal-network (PMN) based on lignin that shows unique applicability. In this work, by self-assembly of double PMN formed by lignin, plant tannins (TA) and Fe ions, a universal gravel-like lignin catalysts were reported for cost-efficient water purification. A controllable self-assembly technique dependent in pH was developed, achieving the controllable synthesis of materials with highly uniformity.

Exploring prognostic biomarkers in pathological images of colorectal cancer patients via deep learning.

Hematoxylin and eosin (H&E) whole slide images provide valuable information for predicting prognostic outcomes in colorectal cancer (CRC) patients. However, extracting prognostic indicators from pathological images is challenging due to the subtle complexities of phenotypic information. We trained a weakly supervised deep learning model on data from 640 CRC patients in the prostate, lung, colorectal, and ovarian (PLCO) cancer screening trial dataset and validated it using data from 522 CRC patients in the cancer genome atlas (TCGA) dataset.

SIRT1 activation by Ligustrazine ameliorates migraine via the paracrine interaction of microglia and neurons.

Background: Neuroinflammation with associated oxidative stress aggravates the pathogenesis and progression of migraine. Ligustrazine (LGZ) is a key component from traditional edible-medicinal herb Ligusticum chuanxiong Hort., and has the effects of anti-platelet aggregation, expanding small arteries, improving microcirculation and promoting blood circulation and removing blood stasis in clinic.

Differentiated thyroid cancer and adverse pregnancy outcomes: a propensity score-matched retrospective cohort study.

Background: Differentiated thyroid cancer (DTC) has been increasingly common in women of reproductive age. However, the evidence remains mixed regarding the association of DTC with adverse pregnancy outcomes in pregnant women previously diagnosed with DTC.

Methods: We conducted a retrospective cohort study in the Peking University Third Hospital in Beijing, China between January 2012 and December 2022.

Knockdown of LncRNA-HAGLR restrains the viability and motility of pancreatic cancer via miR-625-5p/TAF15 axis and .

Dysregulation of long non-coding RNAs (lncRNAs) has been strongly involved to the development of pancreatic cancer (PC). However, the potential mechanisms by which lncRNA regulate PC development still need to be further explored. We attempted to elucidate the functional role and regulatory mechanism of lncRNA HAGLR on PC progression and .

QBT improved cognitive dysfunction in rats with vascular dementia by regulating the Nrf2/xCT/GPX4 and NLRP3/Caspase-1/GSDMD pathways to inhibit ferroptosis and pyroptosis of neurons.

Background: The novel phthalein component QBT, extracted from Ligusticum chuanxiong, shows promising biological activity against cerebrovascular diseases. This study focused on ferroptosis and pyroptosis to explore the effects of QBT on nerve injury, cognitive dysfunction, and related mechanisms in a rat model of vascular dementia (VaD).

Methods: We established a rat model of VaD and administered QBT as a treatment.

Safety evaluation of extracorporeal shockwave lithotripsy for pancreatic stones: Experience based on a large chronic pancreatitis cohort.

Background: The safety of extracorporeal shock wave lithotripsy for pancreatic stones (P-ESWL) and adverse events were not evaluated and classified within large sample population. This study aimed to evaluate the safety and classify the adverse events of P-ESWL based on a large sample cohort.

Methods: This is an observational study based on the large prospective chronic pancreatitis (CP) cohort.