Safety of butylphthalide and edaravone in patients with ischemic stroke: a multicenter real-world study.

Background: Butylphthalide (NBP) and edaravone (EDV) injection are common acute ischemic stroke medications in China, but there is a lack of large real-world safety studies on them. This study aimed to determine the incidence of adverse events, detect relevant safety signals, and assess the risk factors associated with these medications in real-world populations.

Methods: In this study, data of acute ischemic stroke patients were extracted from the electronic medical record database of six tertiary hospitals between January 2019 and August 2021.

Batch-to-batch consistency trial of an adenovirus type-5 vector-based COVID-19 vaccine in adults aged 18 years and above.

Background: The demonstration of batch-to-batch consistency is indispensable for quality control of vaccines.

Methods: We conducted a randomized, double-blind, parallel-controlled trial to evaluate the immunogenicity consistency of a single shot of Ad5-nCoV in healthy adults who had not previously received any COVID-19 vaccine. All eligible participants were randomly assigned equally to receive one of the three consecutive batches of Ad5-nCoV (5 × 10 viral particles/vial, 0.

Thyroid ultrasound image classification using a convolutional neural network.

Background: Ultrasound (US) is widely used in the clinical diagnosis of thyroid nodules. Artificial intelligence-powered US is becoming an important issue in the research community. This study aimed to develop an improved deep learning model-based algorithm to classify benign and malignant thyroid nodules (TNs) using thyroid US images.

A new megastimane sesquiterpenoid from the leaves of .

A new megastimane sesquiterpenoid, cassianol A (), and five known analogues () were isolated from the leaves extract of Their structures were elucidated by extensive spectroscopic methods and single-crystal X-ray diffraction analyses. All the isolates were isolated from for the first time. The anti-inflammatory activities of compounds were evaluated against nitric oxide (NO) production in LPS-induced RAW 264.

Nine new dichapetalin-type triterpenoids from the twigs of Dichapetalum gelonioides (Roxb.) Engl.

Nine previously undescribed dichapetalin-type triterpenoids (1-9), along with 12 reported compounds (10-21), were isolated from the twigs of Dichapetalum gelonioides. Their chemical structures were mainly elucidated by comprehensive analysis of HRMS, 1D and 2D NMR spectroscopic data. The absolute configuration of compound 1 was further determined based on single-crystal X-ray diffraction.

Effects of Prior Influenza Exposure on Immunogenicity of Influenza Vaccine.

Background: In this study, we investigated the effects of prior influenza exposure on vaccine-elicited humor immune responses to circulating influenza variants.

Method: We randomly selected 360 participants in previous clinical trials stratified by age. Blood samples were collected and tested by hemagglutination-inhibition tests during the 2015-2016 influenza seasons in China.

Interlaboratory analysis of teicoplanin plasma concentration assays among Chinese laboratories.

What Is Known And Objective: Teicoplanin is widely used for the treatment of infections caused by drug-resistant Gram-positive bacteria. Since there is a good correlation between trough levels and clinical outcome, therapeutic drug monitoring (TDM) is recommended to achieve better clinical curative effects. However, TDM of teicoplanin is not routine in China.

DPY30 regulates cervical squamous cell carcinoma by mediating epithelial-mesenchymal transition (EMT).

Introduction: Set1/MLL complexes are the main histone H3K4 methyltransferases and are crucial regulators of tumor pathogenesis. DPY30 is a fairly uncharacterized protein in the Set1/MLL complex, but it has been reported to regulate tumor growth. However, the exact mechanism by which DPY30 mediates the progression of cervical squamous cell carcinoma (CSCC) remains unknown.

[Identification and Nitrogen Removal Characteristics of the Heterotrophic Nitrification and Aerobic Denitrification Bacterial Strain DK1].

Nitrogen removal by a newly discovered sp. strain, DK1, isolated from activated sludge was investigated. Using glucose as a carbon source and a (C)/(N) ratio of five, batch experiments showed that the aerobic denitrification removal rate was 4.

A novel method for sewage sludge composting using bamboo charcoal as a separating material.

Traditional composting processes must be conducted with a bulking agent to ensure adequate air space for aeration. The bulking agent and composting materials are always completely mixed. A novel layered structure was introduced in sewage sludge composting, in which no bulking agent was used and bamboo charcoal was used as a separating material.

Regioisomeric Tandem Triblock Shape Amphiphiles Based on Polyhedral Oligomeric Silsesquioxanes.

We report the design, synthesis and self-assembly of a series of tandem triblock shape amphiphile regioisomers composed of one rod-like fluorinated polyhedral oligomeric silsesquioxane (FPOSS) cage tethered with two spherical tert-butyl-POSS (tBPOSS) cages in para-, meta-, and ortho-configurations. Precision syntheses are achieved through sequential "click" reactions and the compounds are thoroughly characterized by combined techniques of NMR, FT-IR and MALDI-TOF MS spectroscopy. Only the ortho-isomer forms an ordered lamellae structure induced by the crystallization of perfluoroalkyl-chains and the other two remain amorphous due to frustrated packing by unfavorable regio-configuration.

Enterovirus 71: a whole virion inactivated enterovirus 71 vaccine.

Introduction: Enterovirus A71 (EV71) is the predominant causative agent of hand, foot, and mouth disease (HFMD), which is often associated with severe cases and even deaths. EV71-associated epidemics have emerged as a serious threat to public health, particularly in the Asia-Pacific region.

Areas Covered: We searched PubMed using the terms 'enterovirus 71', 'hand, foot, and mouth disease', and 'vaccine', with no date or language restrictions for all publications before April 27, 2016.

Type 3 iodothyronine deiodinase in neonatal goats: molecular cloning, expression, localization, and methylation signature.

Type 3 iodothyronine deiodinase (DIO3) is an important enzyme in the metabolism of thyroid hormones. It plays critical roles in fetal development and neonatal growth and is especially important for brain development in mammals. In the present study, we profiled the expression pattern and methylation signature of the DIO3 gene in goats.

Metabolites from the endophytic fungus HP-1 of Chinese eaglewood.

Aim: To study the chemical constituents from the fermentation of the endophytic fungus HP-1 of Chinese eaglewood.

Methods: The chemical constituents were isolated by column chromatography on silica gel and Sephadex LH-20, and their structures were elucidated on the basis of spectroscopic analysis.

Results: Four compounds were isolated and identified as 3α, 3β, 10β-trimethyl-decahydroazuleno[6, 7]furan-8, 9, 14-triol (1), 4-hydroxyphenylacetic acid (2), 4-hydroxyphenethyl alcohol (3), and 5-hydroxymethyl-2-furancarboxaldehyde (4).

Metabolites from the endophytic fungus Penicillium sp. FJ-1 of Ceriops tagal.

To investigate the chemical constituents of the endophytic fungus Penicillium sp. FJ-1 of Ceriops tagal, the chemical constituents were isolated by column chromatography on silica gel and Sephadex LH-20. Their structures were elucidated on the basis of spectroscopic analysis.

Genetic phylogeography and maternal lineages of 18 Chinese black goat breeds.

To understand the origin and genetic phylogeography of Chinese black goats, variations of mitochondrial DNA were characterised with 394 goats from 18 breeds, including 91 new individuals from regions poorly studied until now. Comparison of a 481-bp segment revealed a total of 192 haplotypes with 141 variable sites. The haplotype and nucleotide diversities ranged from 0.

Caprine sex affects skeletal muscle profile and MRFs expression during postnatal development.

The important roles of myogenic regulatory factors (MRFs) have been well addressed in the process of mammalian skeletal myogenesis, while limited research has been performed in small ruminants. Furthermore, the effects of gender on the development of skeletal muscle and MRFs expression remain unknown. In this study, we identified the caprine Myf5, Myf6, MyoD and myogenin genes and quantified their expressions at six different postnatal time points by real-time RT-PCR.

Comparison of the effects of laparoscopic hernia repair and Lichtenstein tension-free hernia repair.

Objective: To compare the effects of laparoscopic inguinal hernia repair (LIHR) and Lichtenstein tension-free inguinal hernia repair and to explore the safety and feasibility of LIHR as well as the advantages and disadvantages of these procedures.

Subjects And Methods: In total, 252 patients with inguinal hernia were equally randomized into the transabdominal preperitoneal (TAPP) repair, totally extraperitoneal (TEP) repair, and Lichtenstein tension-free hernia repair groups (n=84 each). Operating time, postoperative pain scores, postoperative scrotal seroma, postoperative local esthesiodermia, postoperative chronic pains, postoperative long-term hernia relapse, and costs of hospitalization were compared among the three groups.

Circadian rhythm in serum iron levels.

This study was aimed at assessing the circadian rhythm of serum iron levels in Chinese healthy subjects. The project was conducted in 19 healthy, Chinese male subjects following a 4-day diet equilibration. Blood samples were collected on day 5 at 0800, 1000, 1200, 1400, 1600, 1800, 2000, and 2400 hours to determine endogenous serum iron concentrations.

Comparative bioavailability of ferrous succinate tablet formulations without correction for baseline circadian changes in iron concentration in healthy Chinese male subjects: a single-dose, randomized, 2-period crossover study.

Background: Ferrous succinate is used for the treatment of iron deficiency anemia. Determining the bioavailability of iron products is a challenge, because iron is naturally present in the blood and some tissues. Therefore, bioequivalence evaluation of ferrous formulations can be affected by the presence of endogenous iron species.

[Study on arsenic speciation changes in crude and processed traditional Chinese medicines by HPLC-ICP-MS].

A HPLC-ICP-MS method for simultaneous determination of As(III), As(V), MMA and DMA in traditional Chinese medicines (TCMs) was established, and the contents of As(III), As(V), MMA and DMA in a TCM with high total arsenic content (Cordyceps) and 5 crude and processed TCMs (Radix Astragali, Radix et Rhizoma Rhei, Radix Scutellariae, Radix Polygoni Multiflori and Radix Rehmanniae) were determined and analyzed. The method validation indicated that the correlative coefficients (r) for all speciations were bigger than 0.9984; the limits of quantitation (LOQ) were from 0.