Farnesoid X receptor (FXR) is a promising target for treatment of metabolic associated fatty liver disease (MAFLD). In this study, we employed an integrative approach to investigate the interaction between FXR-RXRα-DNA complex and the entire coactivator SRC1-NRID (nuclear receptor interaction domain). We constructed a multi-domain model of FXR-RXRα-DNA, highlighting the interface between FXR-DBD and LBD.
View Article and Find Full Text PDFPhosphorus is considered an ideal anode material for lithium ion storage by virtue of its high theoretical capacity and moderate lithiation potential. However, issues such as large volume expansion of phosphorus leading to an electrical loss of contact and instability of the solid electrolyte interface hinder its practical performance. Improvement strategies that can effectively suppress volume expansion and provide stable electrical contacts are urgently needed.
View Article and Find Full Text PDFIEEE Trans Neural Syst Rehabil Eng
March 2025
Multiple imaging modalities and specific proteins in the cerebrospinal fluid, providing a comprehensive understanding of neurodegenerative disorders, have been widely used for computer-aided diagnosis of Alzheimer's disease (AD). Given the proven effectiveness of contrastive learning in aligning multimodal representation, in this paper, we investigate effective contrastive learning strategies to learn better cross-modal representations for the integration of multi-modal complementary information. To enhance the overall performance in AD diagnosis, we construct a unified hybrid network that integrates feature learning and classifier learning into an end-to-end framework.
View Article and Find Full Text PDFIron reduction in paddy fields is crucial for heavy metal migration and nutrient transformation. Gram-negative iron-reducing bacteria like Geobacter and Shewanella have been widely studied due to their strong extracellular electron transfer capabilities. In contrast, Gram-positive bacteria such as Bacillus and Clostridium are often labeled as weak exoelectrogens, leading to their contributions being overlooked.
View Article and Find Full Text PDFIntroduction The indicator of flow diverters (FDs) received approval extension for small (<7 mm) unruptured intracranial aneurysms (UIAs). However, the factors related to aneurysm occlusion remain unclear. Thus, we conducted a multicenter analysis to explore the risk factors for incomplete occlusion (ICO) following FD implantation for small UIAs.
View Article and Find Full Text PDFConstrained multiobjective optimization problems are widespread in practical engineering fields. Scholars have proposed various effective constrained multiobjective evolutionary algorithms (CMOEAs) for such problems. However, most existing algorithms overlook the differences between different decision variables in influencing the degree of constraint violation and still lack an effective handling mechanism for constraint-sensitive variables.
View Article and Find Full Text PDFProblem: The relationship between abortion and endometriosis (EMS) has been inconsistent in previous observational studies and remains controversial. We intended to examine the causal relationship between abortion and EMS.
Methods Of Study: We conducted a Mendelian randomization (MR) analysis using genome-wide association study (GWAS) summary statistics, drawing data from the FinnGen database and the UK Biobank.
Background: Electroacupuncture (EA), a traditional Chinese medicine therapy, exhibits cardioprotective and therapeutic effects against cardiac injury. However, the precise mechanisms underlying these benefits remain unclear.
Purpose: The aim of this study is to examine the impact of EA on Doxorubicin-Induced heart failure and elucidate the mechanisms involved.
Amyloidoses are predominantly associated with the accumulation of persistent aggregates of a particular protein. For example, the protein α-synuclein characteristically aggregates in Parkinson's disease (PD), while amyloid beta and tau deposits are associated with Alzheimer's disease (AD). However, α-synuclein-positive inclusions have been reportedly found in some tauopathies, and vice versa; tau-positive inclusions can be found in synucleinopathies.
View Article and Find Full Text PDFBackground: Accumulating evidence indicates that the dysbiosis of gastrointestinal microbiota is associated with the development of gastric carcinogenesis. However, the sex-specific traits of gastrointestinal microbiota and their correlation with the sexually dimorphic response to gastric cancer remain poorly understood.
Methods: Male and female transgenic FVB/N insulin-gastrin (INS-GAS) mice as a model of gastric cancer were randomly administered Brucella Broth or Helicobacter pylori (H.
The long-term seasonal pollution characteristics, environmental effects, and sources of atmospheric volatile organic compounds (VOCs) were investigated based on the one-year (06/2021-05/2022) online observation data of VOCs in the central urban area of Chongqing. The results showed that during the observation period, the mean value of (VOCs) was 31.5×10, of which alkane accounted for the highest proportion (39.
View Article and Find Full Text PDFAggregates of α-synuclein (αS) are hallmarks of synucleinopathies, including Parkinson's Disease (PD) and Multiple System Atrophy (MSA). We have recently shown that αS lysine acetylation in the soluble monomer pool varies between healthy controls, PD, and MSA patients. To study the effects of lysine acetylation at all disease-relevant sites of αS, we first compared production of acetylated αS through either native chemical ligation or non-canonical amino acid (ncAA) mutagenesis.
View Article and Find Full Text PDFOrganic compounds present promising options for sustainable zinc battery electrodes. Nevertheless, the electrochemical properties of current organic electrodes still lag behind those of their inorganic counterparts. In this study, nitro groups were incorporated into pyrene-4, 5, 9, 10-tetraone (PTO), resulting in an elevated discharge voltage due to their strong electron-withdrawing capabilities.
View Article and Find Full Text PDFWe present a continuative definition of topological charge to depict the polarization defects on any resonant diffraction orders in photonic crystal slab regardless they are radiative or evanescent. By using such a generalized definition, we investigate the origins and conservation of polarization defects across the whole Brillouin zone. We found that the mode crossings due to Brillouin zone folding contribute to the emergence of polarization defects in the entire Brillouin zone.
View Article and Find Full Text PDFThe yellowfin seabream () is an economically important commercial mariculture fish in China and Southeast Asia. Only a few simple sequence repeats (SSRs) of have been isolated and reported, which has hindered breeding progress. A total of 318,862 SSRs were isolated and characterized from the genome in this study.
View Article and Find Full Text PDFBackground: Reactive Oxygen Species (ROS), a hallmark of cancer, is related to prognosis, tumor progression, and treatment response. Nevertheless, the correlation of ROS-based molecular signature with clinical outcome and immune cell infiltration has not been thoroughly studied in bladder cancer (BLCA). Accordingly, we aimed to thoroughly examine the role and prognostic value of ROS-related genes in BLCA.
View Article and Find Full Text PDFObjective: The study evaluated the effectiveness and safety of single-stage versus multistage endovascular treatment in subarachnoid hemorrhage patients with Mirror Aneurysms.
Materials And Methods: Our research team performed a prospective study, focusing on the radiographic and clinical data of patients diagnosed with subarachnoid hemorrhage, specifically those who presented with Mirror Aneurysms upon admission to our institutions. According to the different endovascular treatment stages, these patients were grouped into the multistage cohort and the single-stage cohort.
The treatment and repair of bone tissue damage and loss due to infection, tumours, and trauma are major challenges in clinical practice. Artificial bone scaffolds offer a safer, simpler, and more feasible alternative to bone transplantation, serving to fill bone defects and promote bone tissue regeneration. Ideally, these scaffolds should possess osteoconductive, osteoinductive, and osseointegrative properties.
View Article and Find Full Text PDFThe approval of Epidiolex, an anti-epileptic drug containing cannabidiol (CBD) as its active component, has brought hope to patients with refractory epilepsy. However, the anti-seizure effect of full-spectrum hemp extract (HE), a CBD-enriched hemp oil, remains unclear. In this study, we investigated the anti-seizure effect of HE using drug-induced seizure models.
View Article and Find Full Text PDFrenal transplant carcinoma, especially in the context of bilateral renal carcinoma, is rare and often presents as small, low-grade papillary renal cell carcinoma (RCC). There is currently no consensus or effective treatment for advanced metastatic RCC after kidney transplantation. A 40-year-old man developed renal transplant carcinoma with venous thrombus and lung metastases 13 years after transplantation.
View Article and Find Full Text PDFMedicine (Baltimore)
December 2024
Rationale: Antibiotic-associated hemorrhagic colitis (AAHC) is a special type of antibiotic-associated colitis. Due to the increased use of antibiotics, especially amoxicillin, which is commonly used in clinical practice, the incidence of antibiotic-associated hemorrhagic colitis has also increased. However, doctors have insufficient understanding of this disease, and patients may be missed or misdiagnosed.
View Article and Find Full Text PDFThe quality performance of power equipment suppliers is directly related to the stable and safe operation of the grid. This study presents a decision-making model based on q-rung orthopair fuzzy sets (q-ROFS) to evaluate suppliers, focusing on quality as the key criterion. To assess the objectivity and comprehensiveness of the results, we provide an innovative information fusion method that integrates the four dimensions of supply risk, supplier quality capability, profit impact, and willingness into the decision-making process.
View Article and Find Full Text PDFACS Appl Mater Interfaces
December 2024