Publications by authors named "Penfold R"

Introduction: Delirium is a common, severe neuropsychiatric syndrome in hospitalised older adults. We evaluated use of validated delirium assessment tools, adherence to national guidelines and prevalence and management of delirium across Scotland, identifying barriers to effective care.

Methods: Secondary analysis of national survey data, collected by participating clinicians on World Delirium Awareness Day (15 March 2023).

View Article and Find Full Text PDF

Importance: An improved understanding of autism spectrum disorder (ASD) prevalence over time and across the lifespan can inform health care service delivery for the growing population of autistic children and adults.

Objective: To describe trends in the prevalence of ASD diagnoses using electronic records data from a large network of health systems in the US.

Design, Setting, And Participants: This cross-sectional study examined annual diagnosis rates in health records of patients in US health systems from January 1, 2011, to December 31, 2022.

View Article and Find Full Text PDF

Background: Antipsychotic medications (AP) are inappropriately prescribed to young people. The goal of this pragmatic trial was to test a four-component approach to improved targeting of antipsychotic prescribing to people aged ≥3 and <18 years.

Methods: Clinicians in four health systems were cluster randomized by the number of previous AP orders and service line - specialty mental health and all others.

View Article and Find Full Text PDF
Article Synopsis
  • - The FDA's Sentinel Innovation Center created a quality-checked network using electronic health records (EHRs) and insurance claims data from over 10 million individuals to enhance regulatory decision-making with real-world data.
  • - The resulting network, called the Real-World Evidence Data Enterprise (RWE-DE), includes data from two commercial sources covering 21 million lives and four academic partners covering 4.5 million lives.
  • - The report details data completeness, patient populations, and a process for managing free-text notes, while also highlighting potential use cases for RWE-DE to address broader questions in healthcare regulation.
View Article and Find Full Text PDF

Objectives: The aim of this study was to investigate GPT-3.5 in generating and coding medical documents with International Classification of Diseases (ICD)-10 codes for data augmentation on low-resource labels.

Materials And Methods: Employing GPT-3.

View Article and Find Full Text PDF

To understand the impact of the transition to telehealth during COVID-19 on psychotherapy visits for patients with dementia. Retrospective study of older adults with dementia who had at least one psychotherapy visit in the 9 months before and after the onset of COVID-19 at 3 U.S.

View Article and Find Full Text PDF

Antipsychotics carry a higher-risk profile than other psychotropic medications and may be prescribed for youth with conditions in which other first-line treatments are more appropriate. This study aimed to evaluate the population-level effect of the Safer Use of Antipsychotics in Youth (SUAY) trial, which aimed to reduce person-days of antipsychotic use among participants. We conducted an interrupted time series analysis using segmented regression to measure changes in prescribing trends of antipsychotic initiation rates pre-SUAY and post-SUAY trial at four U.

View Article and Find Full Text PDF

Importance: Telemedicine use was common during the COVID-19 pandemic, expanding many patients' approaches to accessing health care. Of concern is whether telemedicine access was poorer among higher-needs and disadvantaged populations.

Objective: To assess patient characteristics associated with telemedicine use and telemedicine mode and describe telemedicine visit experiences by telemedicine mode.

View Article and Find Full Text PDF

Objective: This study examined atypical antipsychotic prescribing by Food and Drug Administration (FDA) approved-use (on-label) status for adolescents before and during the COVID-19 pandemic.

Methods: Retrospective data were collected from electronic health records (EHRs) of adolescents aged 10-17 years in Kaiser Permanente Northern California. New outpatient atypical antipsychotic prescription orders during 2013-2021 were evaluated.

View Article and Find Full Text PDF

Background: Multiple short delirium detection tools have been validated in research studies and implemented in routine care, but there has been little study of these tools in real-world conditions. This systematic review synthesized literature reporting completion rates and/or delirium positive score rates of detection tools in large clinical populations in general hospital settings.

Methods: PROSPERO (CRD42022385166).

View Article and Find Full Text PDF

Currently, the prevalence of autism spectrum disorder (henceforth "autism") is 1 in 36, an increasing trend from previous estimates. In 2015, the United States adopted a new version (International Classification of Diseases, 10th Revision) of the World Health Organization coding system, a standard for classifying medical conditions. Our goal was to examine how the transition to this new coding system impacted autism diagnoses in 10 healthcare systems.

View Article and Find Full Text PDF

Background: Given the low usage of virtual health care prior to the COVID-19 pandemic, it was unclear whether those living in rural locations would benefit from increased availability of virtual mental health care. The rapid transition to virtual services during the COVID-19 pandemic allowed for a unique opportunity to examine how the transition to virtual mental health care impacted psychotherapy disruption (i.e.

View Article and Find Full Text PDF

Introduction: People enrolled in Medicaid managed care who struggle with diabetes control often have complex medical, behavioral, and social needs. Here the authors report the results of a program designed to partner with primary care teams to address those needs.

Methods: A nonprofit organization partnered with a Medicaid managed care plan and a Federally Qualified Health Center in California to enroll people with A1cs 9% in a 12-month program.

View Article and Find Full Text PDF

Objective: To understand how race and serious mental illness (SMI) interact for disruptive life events defined as financial (bankruptcy and judgement filings), and non-financial (arrests).

Methods: Patients were adults with schizophrenia (SCZ; N = 16,159) or bipolar I disorder (BPI; N = 30,008) matched 1:1 to patients without SMI (non-SMI) from health systems in Michigan and Southern California during 1/1/2007 through 12/31/2018. The main exposure was self-reported race, and the outcome was disruptive life events aggregated by Transunion.

View Article and Find Full Text PDF

Objective: This study aimed to examine population-level disruption in psychotherapy before and after the rapid shift to virtual mental health care induced by the onset of the COVID-19 pandemic in the United States.

Methods: This retrospective study used electronic health record and insurance claims data from three U.S.

View Article and Find Full Text PDF

Background: Booster COVID-19 vaccines have shown efficacy in clinical trials and effectiveness in real-world data against symptomatic and severe illness. However, some people still become infected with SARS-CoV-2 following a third (booster) vaccination. This study describes the characteristics of SARS-CoV-2 illness following a third vaccination and assesses the risk of progression to symptomatic disease in SARS-CoV-2 infected individuals with time since vaccination.

View Article and Find Full Text PDF
Article Synopsis
  • * Out of 3613 patients studied, those who completed more of the Big 6 interventions, especially pain relief and blood investigations, showed significantly lower mortality rates at 90 days and one year.
  • * Completing all six interventions was linked to a shorter wait time for surgery (2.4 hours) and an average 2.3-day reduction in hospital stay, highlighting the importance of these measures in emergency care.
View Article and Find Full Text PDF
Article Synopsis
  • Cognitive impairment post-SARS-CoV-2 infection can occur in community-based individuals, with studies previously focusing mainly on hospitalized cases.
  • A cohort study in the UK assessed cognitive performance in participants with and without COVID-19, measuring working memory, attention, and other cognitive skills over two rounds.
  • Findings showed individuals with prior SARS-CoV-2 infections exhibited lower cognitive accuracy, particularly those with prolonged symptoms (≥12 weeks), with deficits comparable to age-related cognitive decline.
View Article and Find Full Text PDF