Publications by authors named "Penelope Dessay"
Article Synopsis
- Autosomal recessive PRKCD deficiency is linked to systemic lupus erythematosus, but its specific mechanisms are not well understood.
- Researchers created a mouse model with the Prkcd G510S mutation to study the disease, which mimics human symptoms and shows a shortened lifespan.
- The study found that this mutation affects B cell activation through the PI3K/mTOR pathway, leading to autoimmune symptoms that improve with rapamycin treatment, highlighting the pathway's role in PRKCD-related autoimmunity and reduced NK cell levels contributing to viral infection susceptibility.
