Publications by authors named "Pendyala Pushpanjali"
Page 1 of 1
Synopsis of recent research by authors named "Pendyala Pushpanjali"
- Pendyala Pushpanjali's research primarily investigates the mechanisms of innate immunity, particularly focusing on the Nod-like receptor family card containing 4 (NLRC4) and its role in autoinflammatory syndromes.
- A significant finding from the research highlights that disease-associated mutations in NLRC4 lead to enhanced interaction with SUG1, resulting in increased caspase-8 activation and subsequent cell death, which suggests a critical link between mutation-induced alterations and disease phenotypes.
- The study underscores the complexity of NLRC4 mutations, demonstrating that while all mutations provoke constitutive caspase-1 activation, they differ in their phenotypic outcomes, indicating a need for deeper understanding of each mutation's unique impact on immune response.
