Background: High value care (HVC), maximizing quality while minimizing cost, has become a major focus of surgical practice. Effective education in healthcare value concepts is critical during residency to ensure graduates are able to deliver high value surgical care and participate in interprofessional teams to improve the system.
Study Design: An HVC curriculum was implemented at a single academic medical center.
Background: Trauma is the leading cause of mortality in the pediatric population >1 year. Analyzing relationships between pediatric trauma-related mortality and geographic access to trauma centers (among other social covariates) elucidates the importance of cost and care effective regionalization of designated trauma facilities.
Methods: Pediatric crude injury mortality in 49 United States served as a dependent variable and state population within 45 minutes of trauma centers acted as the independent variable in four linear regression models.
Chitosan has great potential as a pharmaceutical excipient. In this study, chitosan flake was micronized using cryo-ball and cryo-jet milling and subsequently sterilized with nitrogen plasma. Micronized chitosan was characterized by laser diffraction, scanning electron microscopy (SEM), conductometric titration, viscometry, loss on drying, FTIR, and limulus amebocyte lysate (LAL) assays.
View Article and Find Full Text PDFTo investigate the role of the basal ganglia in integrating voluntary and reflexive behaviour, the current study examined the ability of patients with Parkinson's disease to voluntarily control oculomotor reflexes. We measured the size of the fixation offset effect (the reduction in saccadic reaction time when a fixation point is removed) during a block of pro- and a block of anti-saccades. Healthy controls showed the expected reduction of the FOE during the anti-saccades, which results from efforts to suppress reflexive eye movements (a preparatory set characterized by increased internal control and reduced external control).
View Article and Find Full Text PDFAntimicrob Agents Chemother
November 2004
Mammalian platelets release platelet microbicidal proteins (PMPs) as components of their antimicrobial armamentarium. The present studies defined the structure of PMP-1 and examined its structure-activity relationships. Amino acid sequencing and mass spectroscopy demonstrated that distinct N-terminal polymorphism variants of PMP-1 isolated from nonstimulated or thrombin-stimulated platelets arise from a single PMP-1 propeptide.
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