Analysis of cytogenetic damage induced in CHO cells by the pyrethroid insecticide fenvalerate.

A synthetic pyrethroid insecticide, fenvalerate, was tested for its ability to induce chromosome aberrations (CA) and sister chromatid exchanges (SCE) in CHO cells. Fenvalerate was assayed both in the presence and in the absence of a rat liver activation system (S9-mix). Our results indicate that fenvalerate in the presence of S9-mix is able significantly to increase the frequency of CA, while in the SCE test this increase occurred both in the presence and in the absence of S9-mix.

[Cytomegalovirus infection in kidney transplantation].

150 patients, subjected to kidney graft transplantation between January 1988 and December 1989, were studied. Mean +/- 95% CL age was 37.5 +/- 2.

Mutagenic evaluation of trichlorfon using different assay methods with Salmonella typhimurium.

Evaluation of the mutagenicity of trichlorfon pesticide was carried out with strains TA1535, TA100, TA97, TA98 and TA104 of Salmonella typhimurium by means of several assay methods: (i) spot test; (ii) standard plate incorporation test; (iii) plate incorporation test with preincubation; (iv) fluctuation test and (v) fluctuation test with preincubation, with and without post-mitochondrial liver fraction (S9) from Wistar rats pretreated with phenobarbital and 5,6-benzoflavone as a metabolic activation system. Trichlorfon induced base-pair substitution mutations, and its mutagenic activity was decreased by the addition of S9 mix. The fluctuation test and fluctuation test with preincubation were the most sensitive assay methods for detecting the mutagenicity of trichlorfon.

[Clinical experience in diabetes and pregnancy].

We followed patients with pregnancy and diabetes in an outpatient clinic. 240 had gestational diabetes, 16 had type II and 5 type I diabetes. 85% of 110 patients with gestational diabetes had normal glucose tolerance test post partum (AGT).

Influence of bacterial growth of the overnight culture on the captan- and folpet-induced reversion in the Ames test.

The influence of the stage of bacterial growth of the overnight culture on captan- and folpet-induced reversion in the Ames test was investigated. Tests were performed in order to determine both the number of viable bacteria at different intervals of bacterial growth--in the presence or absence of captan and folpet--and also the number of revertants. Captan or folpet were tested at 5 micrograms per plate, a concentration which had previously showed a mutagenic effect to the TA100 strain.

[Antigenic diversity of Plasmodium falciparum and serodiagnosis of tropical malaria].

The importance of antigenic diversity in immunogenicity of population of P. falciparum was studied in regard of immunodiagnosis of tropical malaria. The sera from 42 adult non-immune persons with confirmed infection by P.

Mutagenic evaluation of the pesticides captan, folpet, captafol, dichlofluanid and related compounds with the mutants TA102 and TA104 of Salmonella typhimurium.

A mutagenic evaluation of captan, folpet, captafol, dichlofluanid and related compounds was carried out using the Salmonella/mammalian microsome test using strains TA102 and TA104. These strains contain A-T base pairs at the site of the mutation in contrast to the other Salmonella tester strains that detect mutagens damaging G-C base pairs. In addition, the excision repair system of the TA102 strain is still intact.

[Ambulatory therapy with amphotericin B].

Therapy of systemic fungal infection with amphotericin B (AmB) must be continued for several months and is usually performed on an inpatient basis because of the risk of drug toxicity. Between 1983 and 1987 we treated 14 outpatients with a total of 164 AmB infusions. Side effects were generally mild and easy to control.

Rapid ethnographic assessment: applications in a diarrhea management program.

This paper reports on a rapid ethnographic assessment methodology (REA) that was developed as an essential component of the dietary management of diarrhea (DMD) program. The DMD program is an interdisciplinary research project that has been developed to design intervention programs to reduce or eliminate the nutritional complications of diarrhea in Peru and Nigeria. Anthropological data gathering was an important component of the intervention design, but time and budgetary constraints required a rapid methodological approach.

[Mutagenic evaluation of the urine of rats treated with oils implicated in the toxic oil syndrome using bacterial tests].

The mutagenic activity of the urine of pregnant rats treated with toxic oil syndrome-related rape seed oil or with edible oil was evaluated by means of the Ames and Green tests. It was found that the urine of the pregnant rats treated with "Jen" oil, that was related to the toxic oil syndrome, was mutagenic.

[Predictive value of short-term assays of chemical carcinogenesis].

Many agents of our surroundings are mutagenic, and a significant number of the mutagenic agents are carcinogenic. It is then useful to evaluate the short-term screening test allowing to predict the carcinogenic effect of chemicals. The authors make a summary about the predictive value of the existing assays, and write about the need of the systematic use of a convenient battery of tests to detect carcinogenicity in every product to which the human being may be exposed.