[Cycloferon therapy of acute and chronic virus hepatitis C].

Complex clinical and laboratory examination of patients with HCV infection revealed that the use of cycloferon provided earlier normalization of the clinical and biochemical parameters and lower immunological imbalance vs. the basic therapy alone. High antiviral effect of the drug was shown.

[Preparation and characterization of mouse embryonic fibroblasts with K72W mutation in somatic cytochrome C gene].

Mouse embryonic fibroblasts (MEF) with point mutation in somatic cytochrome C gene were generated and characterized. It was shown that substitution of lysine for tryptophan in position 72 (K72W) decreased the proapoptotic functions of cytochrome C in response to staurosporin treatment without disrupting its respiratory functions. The presence of this mutation did not affect the pattern of cytochrome C gene expression or its localization inside the cell.

Hydrogel drop microchips with immobilized DNA: properties and methods for large-scale production.

Although gel-based microchips offer significant advantages over two-dimensional arrays, their use has been impeded by the lack of an efficient manufacturing procedure. Here we describe two simple, fast, and reproducible methods of fabrication of DNA gel drop microchips. In the first, copolymerization method, unsaturated groups are chemically attached to immobilized molecules, which are then mixed with gel-forming monomers.