Percutaneous cholecystostomy in elderly patients with acute cholecystitis: Factors influencing mortality, morbidity, and length of hospital stay.

Background: Acute cholecystitis (AC) is increasingly common and imposes a burden on healthcare systems, particularly in the elderly population. While laparoscopic cholecystectomy (LC) is the definitive treatment, percutaneous cholecystostomy (PC) is often preferred based on various factors. The treatment of elderly patients requires a multidisciplinary approach that carefully assesses surgical risks due to age-related changes and comorbidities.

Effects of Cerium Oxide on Kidney and Liver Tissue Damage in an Experimental Myocardial Ischemia-Reperfusion Model of Distant Organ Damage.

Ischemia-reperfusion (I/R) injury is a process in which impaired perfusion is restored by restoring blood flow and tissue recirculation. Nanomedicine uses cutting-edge technologies that emerge from interdisciplinary influences. In the literature, there are very few in vivo and in vitro studies on how cerium oxide (CeO) affects systemic anti-inflammatory response and inflammation.

Biological Characterization of One Oxadiazole Derivative (5(4-Hydroxyphenyl)-2-(N-Phenyl Amino)-1,3,4-Oxadiazole): In Vitro, In Silico, and Network Pharmacological Approaches.

Oxadiazole compounds are of great interest because they have a range of biological activities ranging from antioxidants to anticancer agents. Against this background, we wanted to demonstrate the antioxidant, enzyme inhibitory, and anticancer effects of 5(4-hydroxyphenyl)-2-(N-phenylamino)-1,3,4-oxadiazole (Hppo). Antioxidant abilities were measured through free radical scavenging and reducing power tests.

Thalamo-insular cortex connections in the rat and human.

The insular cortex (ICx) has a role in large a variety of functions. Thalamus plays an important role in modulating cortical functions. The present study aims to show thalamic-ICx connections using the fluoro-gold (FG) tracing method in rats and diffusion tensoring-based tractography (DTI) in humans.

The Effect of Stress Ball on Anxiety and Pain Levels in Angiography: A Randomized Controlled Trial.

Coronary angiography, an invasive diagnostic procedure, often induces pain and anxiety in patients. Despite the potential for alleviating discomfort, the use of stress balls as a nonpharmacological intervention during angiography remains underexplored. This study is aimed at investigating the impact of stress ball application on pain and anxiety levels in patients undergoing angiography.

Factors in the development of refractory status epilepticus in status epilepticus patients.

Objectives: Status epilepticus (SE) is a severe neurological condition associated with a poor prognosis. Refractory status epilepticus (RSE) is a treatment-resistant form of SE with an even worse prognosis. The exact mechanisms underlying the development of RSE are not fully understood.

Investigation of RhoA, ROCK1, and ROCK2 Gene Expressions in Autism Spectrum Disorders.

Objective: Autism Spectrum Disorder (ASD) is a neurodevelopmental condition that emerges in early childhood and is characterized by difficulties in social communication, repetitive behaviors, and restricted interests. The Ras homolog (Rho)/Rho-kinase signaling pathway plays a critical role in maintaining synaptic structure and function, as it regulates the actin cytoskeleton. This study aims to investigate the expression of the Ras homolog (Rho) family member A (), Rho-kinase 1 (), and Rho-kinase 2 () genes within this pathway in relation to ASD.

Could Serum Collectin-11, surfactant protein-A and D be suitable biomarkers for assessing pulmonary damage caused by Rhodococcus equi infection in foals on large farms?

Rhodococcus equi (R. equi) is a primary cause of pyogranulomatous pneumonia of foals between three weeks and five months of age. Early diagnosis of rhodococcal pneumonia has always been considered a preferable approach as it can lead to more successful treatment and better outcomes.

Effect of cementation technique and cement type on the amount of excess cement in implant-supported cement-retained crown restorations: An in vitro study.

Statement Of Problem: Excess cement in implant-supported restorations can lead to peri-implant diseases, and its removal remains a clinical challenge. The optimum method of minimizing excess cement is unclear.

Purpose: The purpose of this in vitro study was to compare 3 cementation techniques and 3 cement types and measure excess cement.

Investigation of the Effects of Ozon and Propolis on the Healing of Bone Defects: An Experimental Study.

Background/aim: This study explores the effects of ozone and propolis on the healing of critically sized bone defects at both the histologic and molecular levels, and the locations and concentrations of osteopontin and osteonectin during healing; both proteins play roles during bone healing.

Materials And Methods: This study used 56 adult male Sprague-Dawley rats of an average weight of 350 g, divided into four groups of 14: a control group, a topical ozone group (O), a topical ozone + systemic propolis (O + PO) group, and a systemic propolis group (PO). Seven rats from each group were sacrificed at the end of week 4 and the other seven at the end of week 6.

Investigation of parents' perceptions of sending their children to swimming courses in terms of various variables.

The study aims to investigate parent's perceptions regarding their children's participation in swimming courses, considering various variables. Within the scope of the study, the "Reasons for Parents Sending Their Children to Swimming Sports Scale," consisting of 21 questions, was utilized. This Scale evaluates three sub-factors: the motivations behind parents sending their children to swimming sports, the impact of swimming sports on their children, and the level of satisfaction with swimming sports.

Perception of Internalized Stigma in Parents of Children With Autism Spectrum Disorder: Investigating the Effects of Depression, Anxiety, and Family Functioning.

Introduction Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder that impacts communication, behavior, and social interaction. It is well-documented that parents of children with ASD often experience psychiatric conditions like anxiety and depression. Nevertheless, research on the perception of internalized stigma, family functioning, and their interconnections is scarce.

Risk factors for neurologic sequelae in children and adolescents with hemophilia after intracranial hemorrhage.

Background: Intracranial hemorrhage (ICH) is reportedly rare but has high morbidity and mortality risk in persons with hemophilia. Although the risk factors that facilitate bleeding are known, the factors affecting the sequelae are not well known.

Objectives: We planned to investigate the risk factors for neurologic sequelae in children and adolescents with hemophilia suffering from ICH.

A rare complication of blood donation: MINOCA.

Blood donation is a life-saving process that involves the temporary loss of a specific blood volume. Although generally safe, it may lead to adverse reactions, particularly in first-time donors. Among these, severe outcomes like myocardial infarction (MI) are extremely rare.

Nutrition, Chewing Ability and Quality of Life in Older Adults With Implant Overdentures: A Prospective Clinical Study.

Objectives: To evaluate the changes in nutritional status, chewing ability and oral health-related quality of life in edentulous individuals who have initially been rehabilitated with immediate complete dentures (CD) which are then transformed to implant-supported overdentures (IOD) after a period of osseointegration.

Background: Compared to those with conventional dentures, individuals with IODs exhibit improved patient-reported outcomes, chewing capacity and biting force. While prior research highlights differences in nutritional markers between these groups, there is limited investigation into intra-individual changes in nutritional status, chewing ability and oral health-related quality of life during the transition from CDs to IODs.

The Effectiveness of Ebselen in Facial Nerve Crush Injury: An Experimental Study.

Background: Ebselen is a neuroprotective drug that protects cellular components from oxidative damage by modulating enzymatic cofactors, metalloproteins, gene expression, antioxidant-anti-inflammatory effects, and immunological systems. Our goal was to compare the efficacy of Ebselen and methylprednisolone on rat facial nerve crush injury.

Methods: Thirty healthy male Wistar rats (mean weight of 245 g) were used in this study.

Evaluation of risk factors for postpartum cerebral venous sinus thrombosis, a multicenter retrospective observational study.

The postpartum period is a well-defined risk factor for cerebral venous sinus thrombosis (CVST). However, it is unclear which patients are at risk for CVST in the postpartum period. Thus, determining some CVST risk factors in postpartum patients may be useful for preventing the disorder in this population.

Determination of nutritional status and protein-energy wasting in patients with diabetic nephropathy.

Objective: This study aims to evaluate the nutritional status of patients with stage 3 and 4 diabetic nephropathy (DN; DN-3 and DN-4) and to explain the effect of DN stages on the prognosis of protein-energy wasting (PEW).

Methods: Data from demographic characteristics, anthropometric measurements, biochemical findings, food consumption records, and the Subjective Global Assessment (SGA) screening tool of 49 patients (25 DN-3; 24 DN-4) who were followed at the nephrology department were collected. The criteria of the International Society of Renal Nutrition and Metabolism (ISRNM) were used to determine PEW.

Detailed surgical description of porcine vascularized thymus lobe transplantation.

Background: Despite advances in immunosuppressive therapies, chronic rejection and immunosuppression-related complications remain significant challenges in transplantation. Developing transplantation tolerance through thymus transplantation may offer a solution. This paper details our technique for procuring and transplanting porcine vascularized thymic lobes (VTL), which can be utilized to study and research allogeneic and xenogeneic transplantation models in large animals.

Inhibitor development upon switching from plasma-derived to recombinant factor VIII in previously untreated patients with severe hemophilia A: the PUP-SWITCH study.

Background: The SIPPET randomized clinical trial showed that in previously untreated patients (PUPs) with severe hemophilia A, treatment with plasma-derived factor (F)VIII (pdFVIII) within the first 50 exposure days (EDs) was associated with a lower cumulative incidence of inhibitors than with recombinant FVIII (rFVIII). Switching to rFVIII beyond 50 EDs with pdFVIII is a treatment often implemented by many centers. The question is whether or not this switch may induce a risk of inhibitor development.

Shiga Toxin-Producing E. coli and Hemolytic Uremic Syndrome: A Study of the 2022 Outbreak in Turkey.

BACKGROUND Shiga toxin-producing Escherichia coli (STEC) causes serious bacterial illnesses from consuming undercooked meat and foods contaminated with feces. This study aimed to describe the characteristics of an STEC outbreak associated with hemolytic uremic syndrome (HUS) that emerged in Turkey and affected 21 adults. MATERIAL AND METHODS The medical records of 21 adult patients who were admitted to Ankara Bilkent City Hospital Internal Medicine Intensive Care Department with the diagnosis of HUS between July and September 2022 were retrospectively evaluated through the system.

Outcomes and Craniometric Analyses of the Champy Technique in the Treatment of Mandibular Angle Fractures: A Retrospective Study.

The aim of this study is to examine the outcomes of superiorly placed monocortical single miniplate fixation in the treatment of mandibular angle fractures and evaluate treatment efficacy through craniometric measurements. Postoperative craniometrics were compared with both the preoperative measurements and the control group. Thirty-four patients were included with a mean follow-up of 3.

Nintedanib and its combination with immunosuppressives in connective tissue disease-related interstitial lung diseases.

Background: Nintedanib reduces the decline of pulmonary function in patients with advancing lung fibrosis.

Aim: To assess the characteristics of the patients with connective tissue diseases (CTDs) related to interstitial lung disease (ILD) under nintedanib treatment.

Methods: The CTD-related ILD patients under nintedanib treatment who were followed up between 2020 and 2023 were included in the study.

Juvenile papillomatosis: A case report.

Juvenile papillomatosis (JP) is a very rare benign proliferative breast disease, especially in young women under 30 years of age. Its etiology is not clear yet. Although some patients have breast cancer in their family history, up to 10% breast cancer can develop in the follow-up of JP patients.