Publications by authors named "Pellegrino A"

The abnormal growth of irregular new blood vessels into the subretinal or intraretinal space is known as macular neovascularization (MNV). People over 50 are often affected by this disorder, which is typically brought on by age-related macular degeneration. In addition, MNV can be found in people under 50 years of age, who may present primary ophthalmic diseases such as pathological myopia, angioid streaks, traumatic choroidal rupture, or suspected ocular histoplasmosis syndrome.

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Background: Male professional soccer players frequently compete in multiple matches weekly, and each match significantly impacts their homeostasis, health, and performance. This study evaluates players response at 48 h post-match by combining biological and GPS data. Investigating biochemical and performance metrics offers insights into the physical demands of high-intensity exercise, essential for optimizing performance, recovery, and overall athlete health.

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The study was designed to investigate the pattern of intraventricular Hemo-Dynamic Forces (HDF) and myocardial performance during exercise in Elite Cyclists (EC). Transthoracic stress echocardiography was performed on nineteen EC and thirteen age-matched sedentary controls (SC) at three incremental exercise intensities based on Heart Rate Reserve (HRR). Left Ventricular (LV) HDF were computed from echocardiography long-axis data sets using a novel technique based on endocardial boundary tracking, both in apex-base and latero-septal directions.

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Recently, the use of plant-derived biostimulants has been suggested as a sustainable way to improve the nutritional quality of tomato and mitigate the effects of environmental stresses In this regard, a two-year experiment was conducted in open field on four cultivars of tomato (two commercial tomatoes and two local landraces of long shelf-life tomato), to assess the crop response, in terms of fruit yield and quality traits, to the foliar application of two plant-derived biostimulants based on protein hydrolysates (PH), under opposite water regimes (no irrigation and full irrigation), in a semi-arid environment of South Italy. Tomato plants in field were sprayed with a solution containing one of the two biostimulants approximately every 15 days. Full irrigation significantly promoted plant productivity, leading to yields the 22 % and 57 % higher than those produced under no irrigation.

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  • The study investigates CP symmetry violation in the decay of D^{+} particles into K^{-}K^{+}π^{+} using data from proton-proton collisions at a high energy of 13 TeV.
  • A unique model-independent method was employed to analyze the phase-space distributions of D^{+} and D^{-} particles, correcting for any instrumental biases using D_{s}^{+} decays.
  • The findings indicate no significant evidence of CP violation, with a p value of 8.1%, and measure specific CP asymmetry observables, marking this study as the most sensitive search of its kind in multibody decays.
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Currently, common treatment approaches for neoplastic diseases include surgery, radiation, and/or anticancer drugs (chemotherapy, hormone medications, and targeted therapies). In particular, anticancer medicines destroy cancerous cells by blocking certain pathways that aid in the disease's initiation and progression. These pharmaceutical drugs' capacity to inhibit malignant cells has made them indispensable in the treatment of neoplastic disorders.

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Purpose: The utility of a pelvic drain (PD) after robot-assisted radical prostatectomy (RARP) has been recently questioned. We investigated the impact of discontinuing PD placement after RARP on complications, pain, environmental benefits, and cost savings.

Methods: We identified 1,199 patients who underwent RARP with or without extended pelvic lymph node dissection from 2016 to 2023 at a referral center.

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  • * Findings revealed that while 100% of cyclists were in a state of low energy availability (LEA) at baseline, using individual nutritional interventions significantly reduced this to 14%, unlike the carbohydrate supplementation which had minimal impact.
  • * Overall, factors like training load and body composition affected LEA, but the hot environment did not have a significant effect, highlighting the need for better nutritional education for young athletes.
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  • The study aimed to establish a method for effective nitrogen (N) fertilization in vineyards, as N impacts berry development and winemaking.
  • The research involved five vineyards over four years, analyzing how different N treatment methods affected various plant and soil indicators in relation to N supply.
  • Key findings showed that SPAD (chlorophyll concentration) and YAN (yeast assimilable nitrogen) were critical indicators of N management, providing essential data for improving vineyard management and decision-making regarding fertilization strategies.
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Proximal femoral fractures in elderly women are a major cause of morbidity and mortality worldwide and a public health concern. Although pharmacological therapies have shown potential in improving bone mineral density (BMD) and decreasing fracture risk, the current research effort is focused on developing a procedure that can ensure both immediate and long-term efficacy. A minimally-invasive surgical approach, known as AGN1 local osteo-enhancement procedure (LOEP), has been recently developed to promote bone augmentation.

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This work reports the engineering and functional properties of an emerging class of heterobimetallic 3d-4f ionic complexes designed with cobalt and rare-earth (RE) metals. We present a comprehensive examination of the structural, magnetic, optical, and thermal properties of the heterobimetallic ionic complexes with the general formula [Co(hfa)][RE(hfa)tetraglyme] (RE = Dy, Eu, and Y), where the metal centres are coordinated by hexafluoroacetylacetonate (Hhfa = 1,1,1,5,5,5-hexafluoro-2,4-pentanedione), β-diketone and tetraglyme (2,5,8,11,14-pentaoxapentadecane) polyether. Structural analysis reveals an octahedral coordination geometry enveloping the cobalt(II) centre, characterized by inherent symmetry properties consistent across the derivatives, while a capped square-antiprism coordination polyhedron is observed for the RE ions.

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To develop and validate a novel Comorbidity score for Robotic Surgery (CRS) in predicting severe complications after robot-assisted radical prostatectomy (RARP). Furthermore, we investigated the impact of the surgical platform (Multi-Port - MP vs Single-Port - SP) according to this score. We included 2085 ("development cohort") and 595 ("validation cohort") patients undergoing RARP at two tertiary referral centers between 2014 and March 2024 in a retrospective study.

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  • A study was conducted on B^{+} decays to explore resonant structures using data from the LHCb experiment at various energy levels, totaling an integrated luminosity of 9 fb^{-1}.
  • The researchers performed a simultaneous amplitude fit on two decay channels, determining the C parities of resonances in the D^{*±}D^{∓} mass spectra.
  • Four new charmonium or charmoniumlike states were discovered, including η_{c}(3945) and h_{c}(4000), and the presence of T_{c[over ¯]s[over ¯]0}^{*}(2870)^{0} and T_{c[over ¯]s
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Background: Optic neuropathies represent one of the most frequent causes of vision loss, and they can manifest alone or in conjunction with neurological or systemic symptoms and signs. In recent years, the diagnostic techniques used to detect optic neuropathies have significantly improved, facilitating diagnosis and improving treatment. Among these, ocular ultrasound has assumed a fundamental role, although with conflicting results in the published scientific literature.

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Background: The aim of this study is to provide a comprehensive overview of the da Vinci Single Port robotic platform, including instruments and tools that can aid in implementing the use of this novel platform.

Methods: Footage recorded during various Single port robotic urologic procedures and dry labs performed at two US institutions was used as video material. A step-by-step guide illustrating key points on OR set-up, platform, instruments, trocar configurations, intraoperative suctioning, bedside assistance were discussed and highlighted.

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Background And Objective: Understanding the learning curve for the da Vinci single-port (SP) surgical robot is crucial for adoption, training, and enhancement of surgical safety and efficiency. Our aim was to assess the impact of both overall experience (O-EXP) and procedure-specific experience (PS-EXP) on perioperative outcomes across various SP surgeries.

Methods: We analyzed data for 387 consecutive SP surgeries conducted by a high-volume surgeon from December 2018 to July 2023.

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A measurement of time-dependent CP violation in D^{0}→π^{+}π^{-}π^{0} decays using a pp collision data sample collected by the LHCb experiment in 2012 and from 2015 to 2018, corresponding to an integrated luminosity of 7.7  fb^{-1}, is presented. The initial flavor of each D^{0} candidate is determined from the charge of the pion produced in the D^{*}(2010)^{+}→D^{0}π^{+} decay.

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Nowadays, retinal vein occlusion (RVO) is the second most prevalent cause of vision loss associated with retinal vascular disease. Intravitreal injections are currently known as a major advancement in ophthalmology, particularly in the treatment of RVO and other retinal disorders. Particularly, the first line of therapy is usually anti-vascular endothelial growth factor (VEGF) drugs.

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  • A Belgian study on tick-borne diseases repeated its 2017 research in 2021, focusing on the risk posed by pathogenic microorganisms in ticks that bite humans.
  • Citizens collected and sent in ticks for analysis, identifying various species and testing for several pathogens using advanced qPCR methods.
  • Results showed a decrease in the prevalence of Borrelia burgdorferi but increased rates of Anaplasma phagocytophilum and Rickettsia helvetica compared to 2017, with no detection of tick-borne encephalitis virus in either year.
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The development of highly active, low-cost, and robust electrocatalysts for the oxygen evolution reaction (OER) is a crucial endeavor for the clean and economically viable production of hydrogen electrochemical water splitting. Herein, cuprous oxide (CuO) thin films are deposited on silver nanowire (AgNW) networks by atmospheric-pressure spatial atomic layer deposition (AP-SALD). AgNW@CuO nanocomposites supported on conductive copper electrodes exhibited superior OER activity as compared to bare copper substrate and bare AgNWs.

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Introduction: Outpatient total joint arthroplasty (TJA) is gaining popularity in the United States. With a shift towards value-based healthcare and bundled payment models, the importance of safe discharge after TJA is pertinent in reducing readmissions and subsequent cost of care. However, many acute issues or complications may not occur until after discharge which can result in emergency department visits and readmission.

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Purpose: Single-Port Robot-Assisted Partial Nephrectomy (SP-RAPN) can be performed by transperitoneal and retroperitoneal approaches. However, there is a lack of surgical outcomes for novel Retroperitoneal Low Anterior Access (LAA) in SP-RAPN. The study compared outcomes of the standard approach (SA), considering transperitoneal (TP) and posterior retroperitoneal (RP) access vs LAA in SP-RAPN series.

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Despite advances in patient safety, perioperative patient falls continue to be a persistent and preventable harm. Patient falls in procedural areas have been associated with multiple postoperative complications such as additional falls, functional decline, and hospital readmissions. Although fall-related databases exist, the specific number of periprocedural falls is difficult to ascertain, and the causes of such falls also remain elusive.

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The LHCb Collaboration measures production of the exotic hadron χ_{c1}(3872) in proton-nucleus collisions for the first time. Comparison with the charmonium state ψ(2S) suggests that the exotic χ_{c1}(3872) experiences different dynamics in the nuclear medium than conventional hadrons, and comparison with data from proton-proton collisions indicates that the presence of the nucleus may modify χ_{c1}(3872) production rates. This is the first measurement of the nuclear modification factor of an exotic hadron.

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The majority of neurodegenerative eye disorders occur with aging and significantly impair quality of life. Age-related macular degeneration (AMD) is the third most common cause of visual impairment and blindness worldwide. One of the most important elements in the pathophysiology of neurodegenerative eye disease is certainly oxidative stress, with neuroinflammation and ocular ischemia which may also be significant factors.

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