Use of the Second Victim Experience and Support Tool (SVEST) to Assess the Impact of a Departmental Peer Support Program on Anesthesia Professionals' Second Victim Experiences (SVEs) and Perceptions of Support Two Years After Implementation.

Anesthesia professionals experience events resulting in psychological and physiologic implications, known as second victim experiences (SVEs). This study evaluated the impact of a peer support program on anesthesia providers' SVEs. In July 2018, a departmental peer support program was implemented.

A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit.

Importance: Coenzyme Q10 (CoQ10), an antioxidant that supports mitochondrial function, has been shown in preclinical Parkinson disease (PD) models to reduce the loss of dopamine neurons, and was safe and well tolerated in early-phase human studies. A previous phase II study suggested possible clinical benefit.

Objective: To examine whether CoQ10 could slow disease progression in early PD.

Using previous models to bias structural learning in the hierarchical BOA.

Estimation of distribution algorithms (EDAs) are stochastic optimization techniques that explore the space of potential solutions by building and sampling explicit probabilistic models of promising candidate solutions. While the primary goal of applying EDAs is to discover the global optimum or at least its accurate approximation, besides this, any EDA provides us with a sequence of probabilistic models, which in most cases hold a great deal of information about the problem. Although using problem-specific knowledge has been shown to significantly improve performance of EDAs and other evolutionary algorithms, this readily available source of problem-specific information has been practically ignored by the EDA community.

Use of genetic algorithms with multivariate regression for determination of gelatine in historic papers based on FT-IR and NIR spectral data.

Quantitative non-destructive analysis of individual constituents of historic rag paper is crucial for its effective preservation. In this work, we examine the potentials of mid- and near-infrared spectroscopy, however, in order to fully utilise the selectivity inherent to spectroscopic multivariate measurements, genetic algorithms were used to select spectral data derived from information-rich FT-IR or UV-vis-NIR measurements to build multivariate calibration models based on partial least squares regression, relating spectra to gelatine content in paper. A selective but laborious chromatographic method for the quantification of hydroxyproline (HYP) has been developed to provide the reference data on gelatine content.

Dependency structure matrix, genetic algorithms, and effective recombination.

Abstract In many different fields, researchers are often confronted by problems arising from complex systems. Simple heuristics or even enumeration works quite well on small and easy problems; however, to efficiently solve large and difficult problems, proper decomposition is the key. In this paper, investigating and analyzing interactions between components of complex systems shed some light on problem decomposition.

Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex.

DNA double strand break (DSB) repair by non-homologous end joining (NHEJ) is initiated by DSB detection by Ku70/80 (Ku) and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) recruitment, which promotes pathway progression through poorly defined mechanisms. Here, Ku and DNA-PKcs solution structures alone and in complex with DNA, defined by x-ray scattering, reveal major structural reorganizations that choreograph NHEJ initiation. The Ku80 C-terminal region forms a flexible arm that extends from the DNA-binding core to recruit and retain DNA-PKcs at DSBs.

Mechanism of DNA substrate recognition by the mammalian DNA repair enzyme, Polynucleotide Kinase.

Mammalian polynucleotide kinase (mPNK) is a critical DNA repair enzyme whose 5'-kinase and 3'-phoshatase activities function with poorly understood but striking specificity to restore 5'-phosphate/3'-hydroxyl termini at sites of DNA damage. Here we integrated site-directed mutagenesis and small-angle X-ray scattering (SAXS) combined with advanced computational approaches to characterize the conformational variability and DNA-binding properties of mPNK. The flexible attachment of the FHA domain to the catalytic segment, elucidated by SAXS, enables the interactions of mPNK with diverse DNA substrates and protein partners required for effective orchestration of DNA end repair.

Structure and flexibility within proteins as identified through small angle X-ray scattering.

Flexibility between domains of proteins is often critical for function. These motions and proteins with large scale flexibility in general are often not readily amenable to conventional structural analysis such as X-ray crystallography, nuclear magnetic resonance spectroscopy (NMR) or electron microscopy. A common evolution of a crystallography project, once a high resolution structure has been determined, is to postulate possible sights of flexibility.

Automated global structure extraction for effective local building block processing in XCS.

Learning Classifier Systems (LCSs), such as the accuracy-based XCS, evolve distributed problem solutions represented by a population of rules. During evolution, features are specialized, propagated, and recombined to provide increasingly accurate subsolutions. Recently, it was shown that, as in conventional genetic algorithms (GAs), some problems require efficient processing of subsets of features to find problem solutions efficiently.

Database independent detection of isotopically labeled MS/MS spectrum peptide pairs.

Mass spectrometry data generated in differential profiling of complex protein samples are classically exploited using database searches. In addition, quantitative profiling is performed by various methods, one of them using isotopically coded affinity tags, where one typically uses a light and a heavy tag. Here, we present a new algorithm, ICATcher, which detects pairs of light/heavy peptide MS/MS spectra independent of sequence databases.

[Endemic incidence of Mycobacterium kansasii infection in Karvina District 1968-1999; overview of the descriptive characteristics].

The objective of the submitted work was to present a summary of basic epidemiological data in a group of 1034 subjects from whom during the period between 1968-1999 Mycobacterium kansasii was isolated. In the analysis of the group principles of the descriptive epidemiological method were used. In the first years, when diseases were recorded and the number of cases increased, epidemiologists of the District Hygiene Station in Karviná made an investigation.

Linkage problem, distribution estimation, and Bayesian networks.

This paper proposes an algorithm that uses an estimation of the joint distribution of promising solutions in order to generate new candidate solutions. The algorithm is settled into the context of genetic and evolutionary computation and the algorithms based on the estimation of distributions. The proposed algorithm is called the Bayesian Optimization Algorithm (BOA).

Endemic incidence of infections caused by Mycobacterium kansasii in the Karviná district in 1968-1995 (analysis of epidemiological data--review).

The Karviná district (northwestern part of North Moravia and Silesia) is typical by its industrial character, above all mining of black coal which is coked and which led to the devastation of the countryside. The ratio of light industry is low. In a small area (347 km2) there is a population of 824 inhabitants per km2.

[1000 laparoscopic cholecystectomies--evaluation of complications].

At the Department of Surgery in Liberec since the middle of 1992 to the end of 1995 one thousand laparoscopic cholecystectomies were performed. Peroperative cholangiography is not used as a routine method. The percentage of conversions declined from 10% to 3% as the technical skill improved.

[Laparoscopic suturing of perforated duodenal and prepyloric ulcers].

The authors submit an account of five patients with a perforated duodenal and prepyloric ulcer. All patients were treated by laparoscopy only. A laparoscopic suture of the perforated ulcer was made without omentoplasty with lavage and drainage.

The immediate asthmatic response to allergen challenge.

One hundred and three bronchial asthma patients with a suspected allergic component developed 133 positive immediate asthmatic (bronchus-obstructive) responses (IARs) to bronchial challenge with allergen (BP). The onset of IAR was within 10 minutes, the maximum within 45 minutes, and the resolution of the response within 120 minutes after the challenge. All IARs were highly significant in comparison with the control test (p less than .

[X-ray computed tomography in a series of aneurysms of the circle of Willis].

During four years, 80 patients with intracranial aneurysms were examined by a CT scanner. The CT was helpful for: The rapid and easy diagnosis of subarachnoid hemorrhage. Direct visualization of intracranial aneurysms.

[A series of 106 cases of ruptured aneurysms operated on during the 1st week].

The authors report 106 intracranial aneurysms operated on during the first 7 days post S.A.H.

[Scanography in head injuries. Critical study of 500 cases].

In 22 months, about 2 000 patients were hospitalized for head injury and 410 of these had computerized tomography to determine the presence and extent of intracranial pathology. 165 patients had normal C.T.

[Intracranial aneurysm and polycystic kidneys].

Five cases of intracranial aneurysms with polycystic kidneys are reported: --15% of polycystic kidneys have an intracranial aneurysm, and about 4% - 5% of intracranial aneurysms are joined with polycystic kidneys; --the surgical treatment of intracranial aneurysm with this association doesn't present more risk than an intracranial aneurysm, and the surgical prognosis isn't bad; --the pathogeny isn't clear. This association is perhaps a congenital elastic system disease.

[Anaesthesia for computerised axial tomography in children (author's transl)].

Computerised axial tomography requires total immobility, which must be obtained by a simple and safe technique of anaesthesia. Three anaesthesia techniques were used and analysed in 54 children aged less than 5 years: the technique of the feeding bottle, sedation with pentobarbital or diazepam and general anaesthesia with ketamine hydrochloride. The technique of the feeding bottle can be proposed in selected patients.

Endemic occurrence of Mycobacterium kansasii in water-supply systems.

Of a total number of 1079 drinking water and colliery service water samples examined in an area of the North-Moravian Region Czechoslovakia, characterized by endemic occurrence of M. kansasii infections, 233 [21.6%] samples were found to be contaminated by mycobacteria, of these 20 [1.

[Plastic coating in the surgical treatment of intracranial aneurysms. Late results of twenty cases (author's transl)].

The authors reported the late results of a serie of fifteen intracranial aneurysm treated by plastic coating. These fifteen patients belong to a group of twenty cases operated with this technic. Four patients were pre-operatively in stade V.