Significant experimental decrease of the hepatocellular carcinoma incidence in C3H/Sy mice after long-term administration of EB1089, a vitamin D analogue.

EB1089, a vitamin D analogue without the acute side effects of 1alpha,25(OH)2D3, the physiologically active form of vitamin D, exerts strong antiproliferative activities in malignant cells, including hepatoma cells in vitro, and in experimental hepatomas in animals as well. It also induces cell cycle arrest and apoptosis in premalignant conditions, suggesting its application in chemopreventive trials. We examined the possible chemopreventive effect of EB1089 on hepatocellular carcinoma (HCC) incidence in C3H/Sy virgin female mice, a strain developing an incidence of 58% spontaneous HCCs.

Lymphocyte activation by granulocyte macrophage-colony stimulating factor in human bladder cancer.

Objectives: The goal of this study was to investigate the ablative or reductive activity of granulocyte macrophage-colony stimulating factor (GM-CSF) instillations on transitional cell carcinoma marker lesions as well as its ability to increase and/or activate lymphocyte population.

Methods: Eleven patients (pts) with newly diagnosed cancer pTa-pT1 were studied. A well-defined marker lesion (< or = 0.

Intranuclear Helioid Inclusions in a Case of Breast Carcinoma.

Helioid inclusions are single membrane-bounded intranuclear bodies of unknown nature which have been described in a case of breast adenoma, in mammary hyperplasia, and in a case of acinic cell carcinoma of the parotid gland. We report the detection of helioid inclusions in a case of breast carcinoma, which involves a 60-year-old woman with infiltrating ductal breast carcinoma of apocrine type. On electron microscopic examination we observed characteristic intranuclear helioid inclusions in some carcinoma cells.