The expression of cyclooxygenase-1 and -2 in proliferative endometrium and endometrial adenocarcinoma.

Background: The activity of cyclooxygenase-2 (COX-2) is increased in inflammation and in several cancer types. We investigated the expression of COX-2, cyclooxygenase-1 (COX-1), nitric oxide synthase-2 (NOS-2) and nitric oxide synthase-3 (NOS-3) in normal proliferative and secretory human endometrium, and in endometrial adenocarcinoma.

Methods: Human endometrium was collected at hysterectomy.