Publications by authors named "Pejvak Moghimi"
Article Synopsis
- The study created a comprehensive reference atlas of human prenatal skin (7-17 weeks post-conception) using advanced techniques like single-cell and spatial transcriptomics to explore the roles of immune cells, specifically macrophages, in skin development.
- It was found that interactions between immune and non-immune cells are essential for key processes in skin development, such as hair follicle formation, scarless wound healing, and blood vessel growth.
- Additionally, while a skin organoid model mimicked certain features of prenatal skin, it lacked immune cells and showed limited blood vessel diversity, highlighting the important roles of macrophages and their derived factors in skin morphology and development.
Article Synopsis
- The study aimed to overcome barriers in creating effective cancer vaccines by combining hTERT peptides with therapies that target regulatory T cells (Tregs) and reduce immune suppression from COX2.
- A Phase 1 trial involved 29 patients with advanced solid tumors, focusing on safety and immune response while monitoring side effects like fatigue and nausea.
- Findings showed that while the treatment was safe and led to some immune cell expansion specific to hTERT, further improvement in clinical effectiveness may come from adding anti-PD1 therapies to tackle exhausted T cells.
The adaptive immune system generates an incredible diversity of antigen receptors for B and T cells to keep dangerous pathogens at bay. The DNA sequences coding for these receptors arise by a complex recombination process followed by a series of productivity-based filters, as well as affinity maturation for B cells, giving considerable diversity to the circulating pool of receptor sequences. Although these datasets hold considerable promise for medical and public health applications, the complex structure of the resulting adaptive immune receptor repertoire sequencing (AIRR-seq) datasets makes analysis difficult.
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