Publications by authors named "Peizhuo Pang"
Enhancer-mediated FOXO3 expression promotes MSC adipogenic differentiation by activating autophagy.
Biochim Biophys Acta Mol Basis Dis
February 2024
Article Synopsis
- Mesenchymal stem cells (MSCs) can differentiate into various cell types, but in osteoporosis, this process shifts towards fat cell (adipocyte) formation due to the role of the FOXO3 gene.* -
- The study used RNA sequencing and other methods to show that FOXO3 not only drives the expression of key fat cell transcription factors but is also involved in a positive feedback loop that enhances its own expression.* -
- By activating the PI3K-AKT pathway, FOXO3 promotes autophagy, which is linked to MSCs turning into adipocytes, suggesting that targeting FOXO3 could be a potential treatment strategy for osteoporosis.*