CAD in clinical trials: current role and architectural requirements.

Computer-aided diagnosis (CAD) technology is becoming an important tool to assess treatment response in clinical trials. However, CAD software alone is not sufficient to conduct an imaging-based clinical trial. There are a number of architectural requirements such as image receive (from multiple field sites), a database for storing quantitative measures, and data mining and reporting capabilities.

An architecture for computer-aided detection and radiologic measurement of lung nodules in clinical trials.

Computer tomography (CT) imaging plays an important role in cancer detection and quantitative assessment in clinical trials. High-resolution imaging studies on large cohorts of patients generate vast data sets, which are infeasible to analyze through manual interpretation. In this article we describe a comprehensive architecture for computer-aided detection (CAD) and surveillance on lung nodules in CT images.