Publications by authors named "Peiyi Li"

Background: Lupus nephritis (LN) frequently manifests as a significant complication in systemic lupus erythematosus (SLE) patients, with emerging research indicating a plausible correlation between subclinical retinal involvement and renal manifestations. This study aims to investigate the relationship between the neutrophil-to-C3 ratio (NC3R) and both LN as well as retinal microvasculature damage among SLE patients.

Methods: In this cross-sectional study, a cohort of 220 participants (78 LN and 142 non-LN) was recruited.

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Wearable temperature-sensitive electronic skin enables robots to rapidly detect environmental changes and respond intelligently, thereby reducing temperature-related mechanical failures. Additionally, this temperature-sensitive skin can measure and record the temperature of external objects, broadening its potential applications in the medical field. In this study, we designed a thermally sensitive artificial ionic skin using ionic liquids (ILs) as solvents and carbon nanotubes (CNTs) as thermally conductive fillers.

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Objectives: Supporting family caregivers (FCs) is a critical core function of palliative care. Brief, reliable tools suitable for busy clinical work in Taiwan are needed to assess bereavement risk factors accurately. The aim is to develop and evaluate a brief bereavement scale completed by FCs and applicable to medical staff.

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Soft robotics has undergone considerable progress driven by materials that can effectively transduce external stimuli into mechanical actuation. Here, we report the development of a photothermal-responsive hydrogel actuator with shape memory capabilities inspired by the adaptive locomotion of sea cucumbers. This actuator is based on sea cucumber peptides (SCP) and a liquid metal (LM) hydrogel network that is responsive to near-infrared (NIR) light.

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Background: Patients with terminal illness often experience significant physical and mental suffering. This distress affects the patients themselves, as they endure the pain of their condition and their family members, who are affected by the patient's situation and medical decisions. Furthermore, exploring the patients' and their families' concepts of a "good death" is crucial for reflecting on the value of life and for planning treatment or care models (such as advance care planning).

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Epitaxy of rare-earth nitride films are crucial for studying their physical properties and offer significant potential for applications in spintronics and optoelectronics. However, synthesizing single-crystalline LuN presents significant challenges, leading to a limited understanding of its properties. In this study, we successfully achieved the epitaxial growth of (001)-oriented LuN films on YAlO (110) substrates by reactive magnetron sputtering epitaxy.

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Malachite green (MG) is widely used in aquaculture as a parasiticide. It has generated much concern due to its carcinogenesis, mutagenesis, chromosomal fractures, teratogenicity, and respiratory toxicity. Effective methods for removing MG from water or other media are highly needed.

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Chronic pain dramatically affects life qualities of the sufferers. It has posed a heavy burden to both patients and the health care system. However, the current treatments for chronic pain are usually insufficient and cause many unwanted side effects.

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Article Synopsis
  • Nitrogen vacancies in titanium nitrides are effective for tuning their plasmonic properties, but the exact mechanism is still unclear due to challenges in obtaining high-quality samples.
  • Researchers synthesized a series of epitaxial titanium nitride films with different nitrogen vacancy levels and discovered that the plasmon energy can be adjusted significantly based on these vacancies.
  • The study concludes that the changes in electronic states near the Fermi level and the reduced carrier effective mass are key factors influencing the plasmonic properties in titanium nitride, providing insights beneficial for future nitride plasmonic devices.
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Insufficiently managed incisional (INC) pain severely affects patients' life quality and rehabilitation after a major operation. However, mechanisms underlying INC pain still remain poorly understood. A mouse model of INC pain was established by skin plus deep muscle incision.

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Isobutyronitrile finds extensive application in organic synthesis for the production of the insecticide diazinon. Apart from occupational exposure, cigarette smoking may also expose the general population to isobutyronitrile. However, to date, the association between isobutyronitrile and female infertility has not been explored in a population-based study.

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Over 50 billion cells undergo apoptosis each day in an adult human to maintain tissue homeostasis by eliminating damaged or unwanted cells. Apoptotic deficiency can lead to age-related diseases with reduced apoptotic metabolites. However, whether apoptotic metabolism regulates aging is unclear.

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Introduction: Emerging infectious diseases (EIDs) can disrupt the healthcare system, causing regulatory changes that affect the healthcare-seeking process and potentially increase patient-physician dissatisfaction. This study aimed to collect and analyze patients' and physicians' complaints during an EID outbreak to inform potential clues regarding medical quality and patient safety enhancement in future dealing with EIDs, employing text mining methodologies.

Methods: In this descriptive study, complaint records from January 2020 to February 2023 at West China Hospital, a national medical facility in China, were analyzed.

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Article Synopsis
  • Esculetin (ESC) is a natural compound used in traditional Chinese medicine that helps protect the brain during strokes.
  • The study found that ESC helps reduce brain damage and improve behavior in mice after a stroke by affecting a protein called CKLF1.
  • Blocking CKLF1 with ESC also lowers the number of immune cells that can cause more damage, showing that it could be a good treatment for strokes in the future.
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Background: Although clinical decision support systems (CDSS) have been developed to enhance the quality and efficiency of surgeries, little is known regarding the practical effects in real-world perioperative care.

Objective: To systematically review and meta-analyze the current impact of CDSS on various aspects of perioperative care, providing evidence support for future research on CDSS development and clinical implementation.

Methods: This systematic review and meta-analysis followed the Cochrane Handbook and PRISMA statement guidelines, searching databases up to 2 February 2024, including MEDLINE, PubMed, Embase, Cochrane, and Web of Science.

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Postoperative pulmonary complications (PPCs) are highly heterogeneous disorders with diverse risk factors frequently occurring after surgical interventions, resulting in significant financial burdens, prolonged hospitalization and elevated mortality rates. Despite the existence of multiple studies on PPCs, a comprehensive knowledge base that can effectively integrate and visualize the diverse risk factors associated with PPCs is currently lacking. This study aims to develop an online knowledge platform on risk factors for PPCs (Postoperative Pulmonary Complications Risk Factor Knowledge Base, PPCRKB) that categorizes and presents the risk and protective factors associated with PPCs, as well as to facilitate the development of individualized prevention and management strategies for PPCs based on the needs of each investigator.

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Article Synopsis
  • The study examines how deep eutectic solvents (DES), specifically choline chloride-oxalic acid and a blend with glycerol, impact the structure of cellulose when treating cotton fibers.
  • Results show that the ternary solvent mixture helps preserve cellulose integrity better than the binary one, yielding over 90% cellulose recovery.
  • The foams produced from this process demonstrate high water repellency and mechanical strength, suggesting potential applications as environmentally friendly packaging alternatives to plastic.
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This paper addresses the issue of how to endow robots with motion skills, flexibility, and adaptability similar to human arms. It innovatively proposes a hybrid-primitive-frame-based robot skill learning algorithm and utilizes the policy improvement with a path integral algorithm to optimize the parameters of the hybrid primitive framework, enabling robots to possess skills similar to human arms. Firstly, the end of the robot is dynamically modeled using an admittance control model to give the robot flexibility.

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Ischemic stroke is acknowledged as one of the most frequent causes of death and disability, in which neuroinflammation plays a critical role. Emerging evidence supports that the PGK1/Nrf2/HO-1 signaling can modulate inflammation and oxidative injury. Albiflorin (ALB), a main component of Radix paeoniae Alba, possesses anti-inflammatory and antioxidative properties.

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Gouty arthritis causes severe pain and inflammation. Alginate oligosaccharides (AOSs) are natural products derived from alginate and have anti-inflammatory properties. We explored the potential effects of AOSs with different degrees of polymerization (Dp) on gouty arthritis and associated mechanisms.

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Background: The efficacy and prognosis of immune checkpoint inhibitors (ICIs) remain unresolved issues. Here, we assessed the treatment characteristics and efficacy of ICIs in non-small cell lung cancer (NSCLC) using real-world data and evaluated the predictive value of factors, including programmed death-ligand 1 (PD-L1) expression, for the clinical outcome of ICIs in NSCLC.

Methods: Analyzed data was collected from hospitalized patients in the West China Hospital of Sichuan University between January 2017 and March 2023.

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Background: Timely detection of modifiable risk factors for postoperative pulmonary complications (PPCs) could inform ventilation strategies that attenuate lung injury. We sought to develop, validate, and internally test machine learning models that use intraoperative respiratory features to predict PPCs.

Methods: We analysed perioperative data from a cohort comprising patients aged 65 yr and older at an academic medical centre from 2019 to 2023.

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Article Synopsis
  • Researchers modified tannic acid onto cellulose nanofibrils (CNFs) to create TA@CNFs and used this to develop a new self-healing hydrogel with noteworthy strength and flexibility.
  • The resulting PTC double-network hydrogel exhibits impressive mechanical properties, with a fracture stress over 10 times greater than traditional PVA hydrogels and a high fracture strain of 1723%.
  • PTC hydrogel can rapidly self-heal within two minutes, reshape with temperature changes, and adhere to skin to function as a sensitive and stable motion detection sensor.
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Cerebral infarction is one of the most common diseases for aged people. Compound Tongluo Decoction (CTLD), a classic traditional Chinese Medicine prescription, has been widely used in the treatment of ischemic cerebral infarction. Transient middle cerebral artery occlusion (tMCAO) rat model is established for the animal experiment and oxygen-glucose deprivation and reperfusion (OGD/R) human umbilical vein endothelial cells (HUVECs) model are established for the cell experiment.

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Background And Purpose: Ulcerative colitis (UC) is a global refractory disease characterized by recurrent episodes. Coptisine (COP) is an isoquinoline alkaloid derived from Coptis chinensis, which has strong anti-inflammatory activity. Macrophages are key cells mediating inflammation.

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