Rethinking the stability of metal nanoclusters: the individual the collective.

Research on the stability of metal nanoclusters and their molecular/supramolecular chemistry has proceeded significantly independently thus far. We herein have demonstrated that the stability of a nanocluster-based system should be assessed from both the cluster individual aspect (, the energy of the molecular conformer) and the cluster collective aspect (, the energy of the supramolecular lattice). A pair of AuCu cluster polymorphs, including AuCu-triclinic and AuCu-trigonal, was developed here to reveal the energy and stability contributions of both cluster conformers and crystalline lattices to their total systems.

Probing the surface-active sites of metal nanoclusters with atomic precision: a case study of AuAg.

The determination of surface-active sites in metal nanoclusters is of great significance for the in-depth understanding of structural evolutions and physicochemical property mechanisms. In this work, the surface-active sites of the AuAg(DMBT)(DPPOE) cluster template towards metal-/ligand-exchange reactions were unambiguously identified at the atomic level. The active-site tailoring of this nanocluster gave rise to three derivative nanoclusters, AuAgCu(DMBT)(DPPOE), AuAg(DMBT)(DCBT)(DPPOE), and AuAg(DCBT)(DPPOE).

Control the Single-, Two-, and Three-Photon Excited Fluorescence of Atomically Precise Metal Nanoclusters.

It remains challenging to control the single-, two-, and three-photon excited fluorescence of metal nanoclusters. In this work, the control over the non-linear optics of metal nanoclusters as single-, two-, and three-photon excited fluorescence has been accomplished via exploiting the solvent effect. An emissive nanocluster, Au Ag (SPh OMe) (DPPOE) Cl , was synthesized and structurally determined.

Horizontal expansion of biicosahedral M-based nanoclusters: resolving decades-long questions.

For metal nanoclusters with the "cluster of clusters" intramolecular evolution pattern, most efforts have been made towards the vertical superposition of icosahedral nanobuilding blocks (, from mono-icosahedral Au to bi-icosahedral Au and tri-icosahedral Au), while the horizontal expansion of these rod-shaped multi-icosahedral aggregates was largely neglected. We herein report the horizontal expansion of the biicosahedral M cluster framework, yielding an [AuAg(S-Adm)(DPPM)Cl] nanocluster that contains an AuAg kernel and six Au(DPPM)(S-Adm) peripheral wings. The structural determination of [AuAg(S-Adm)(DPPM)Cl] resolved a decades-long question towards rod-shaped multi-icosahedral aggregates: how to load bidentate phosphine and bulky thiol ligands onto the nanocluster framework? The structural comparison between [AuAg(S-Adm)(DPPM)Cl] and previously reported [AuAg(PPh)Cl] or [AuAg(SR)(PPh)Cl] rationalized the unique packing of Au(DPPM)(S-Adm) motif structures on the surface of the former nanocluster.

Reversible transformation between AuAg and AuAg nanoclusters.

Although several approaches have been exploited to trigger the structural transformation of metal nanoclusters, most cases are assigned to the unidirectional conversion, while the reversible conversion of nanoclusters remains challenging. In this work, the reversible conversion between two Au-Ag alloy nanoclusters, AuAg(Dppm)(CN)Cl and AuAg(Dppm)Cl, has been accomplished, which was tracked by UV-vis and ESI-MS spectroscopy. The condition of the nanocluster reversible conversion has been meticulously mapped out.

AuAg nanocluster: Controllable preparation, structural determination, and optical property investigation.

The structure/composition of nanoclusters has a decisive influence on their physicochemical properties. In this work, we obtained two different Au-Ag nanoclusters, [AuAg(SAdm)(dppm)Cl] and AuAg(dppm)(SAdm)(CN), via controlling the Au/Ag molar ratios by a one-pot synthetic approach. The structure of nanoclusters was confirmed and testified by single-crystal x-ray diffraction, electrospray ionization time-of-flight mass spectrometry, XPS, powder x-ray diffraction, and electron paramagnetic resonance.

β-glucan therapy converts the inhibition of myeloid-derived suppressor cells in oral cancer patients.

Objectives: The myeloid-derived suppressor cells (MDSCs) frequently have a high expansion in cancer patients. This research explored whether administration of β-glucan could increase anti-tumor immunity in oral squamous cell carcinoma (OSCC) patients.

Materials And Methods: This study evaluated the MDSC level of circulating blood as CD33 /CD11b /HLA-DR by flow cytometry in 30 healthy donors (HDs, group I), in 48 oral squamous cell carcinoma (OSCC) patients before and after 14-day preoperative administration of β-glucan (group II), and in 52 OSCC patients without taking β-glucan (group III).

Upregulated NPM1 is an independent biomarker to predict progression and prognosis of oral squamous cell carcinomas in Taiwan.

Background: Nucleophosmin/nucleoplasmin family 1 (NPM1) has broad physiological functions, such as DNA replication, transcription, ribosome biogenesis, and centrosome replication. This study explored the clinicopathological importance of NPM1 as a prognostic marker for oral squamous cell carcinoma (OSCC).

Methods: We collected specimens from 96 OSCC, 45 oral epithelial dysplasia (OED), and 29 normal oral mucosa (NOM).