A portable fluorescence sensing system for timely onsite perfluorooctane sulfonate detection based on an aggregate induced emission fluorescence sensor.

Perfluorooctane sulfonate (PFOS), a ubiquitous persistent organic pollutant, has aroused growing concern due to its adverse effects on human health. Timely onsite monitoring of PFOS in heavily contaminated areas is crucial for effective pollution management and prevention of its spread. However, relevant PFOS detection methods have rarely been reported.

Advanced theory of mind and children's prosocial lie-telling in middle childhood: A training study.

Children's advanced theory of mind (AToM) is concurrently associated with their prosocial lie-telling. However, the causal link between AToM and prosocial lie-telling has not yet been demonstrated. To address this gap, the current study adopted a training paradigm and investigated the role of AToM in children's prosocial lie-telling in middle childhood.

Metal-organic framework (MOF)-based materials for pyroptosis-mediated cancer therapy.

Pyroptosis is regarded as a promising strategy to modulate tumor immune microenvironments for anticancer therapy. Although pyroptosis inducers have been extensively explored in the biomedical field, their drug resistance, off-targeting capacity, and adverse effects do not fulfill the growing demands of therapy. Nowadays, metal-organic frameworks (MOFs) with unique structures and facile synthesis/functionalization characteristics have shown great potential in anticancer therapy.

Auditory Effects of Acoustic Noise From 3-T Brain MRI in Neonates With Hearing Protection.

Background: Neonates with immature auditory function (eg, weak/absent middle ear muscle reflex) could conceivably be vulnerable to noise-induced hearing loss; however, it is unclear if neonates show evidence of hearing loss following MRI acoustic noise exposure.

Purpose: To explore the auditory effects of MRI acoustic noise in neonates.

Study Type: Prospective.

The association between PM components and blood pressure changes in late pregnancy: A combined analysis of traditional and machine learning models.

Background: PM is a harmful mixture of various chemical components that pose a challenge in determining their individual and combined health effects due to multicollinearity issues with traditional linear regression models. This study aimed to develop an analytical methodology combining traditional and novel machine learning models to evaluate PM's combined effects on blood pressure (BP) and identify the most toxic components.

Methods: We measured late-pregnancy BP of 1138 women from the Heshan cohort while simultaneously analyzing 31 PM components.

Rationally Designed Benzobisthiadiazole-Based Covalent Organic Framework for High-Performance NIR-II Fluorescence Imaging-Guided Photodynamic Therapy.

Although being applied as photosensitizers for photodynamic therapy, covalent organic frameworks (COFs) fail the precise fluorescence imaging in vivo and phototherapy in deep-tissue, due to short excitation/emission wavelengths. Herein, this work proposes the first example of NIR-II emissive and benzobisthiadiazole-based COF-980. Comparing to its ligands, the structure of COF-980 can more efficiently reducing the energy gap (ΔE) between the excited state and the triplet state to enhance photodynamic therapy efficiency.

[Mechanism of Jiaotai Pills in treatment of depression based on quantitative proteomics].

This study aimed to investigate the effect of Jiaotai Pills on protein expression in the hippocampus of the rat model of chronic unpredictable mild stress(CUMS)-induced depression by quantitative proteomics and explore the anti-depression mechanism of Jiaotai Pills. The SD rats were randomized into control, model, Jiaotai Pills, and fluoxetine groups(n=8). Other groups except the control group were subjected to CUMS modeling for 4 weeks.

Multifunctional Eu-MOF for simultaneous quantification of malachite green and leuco-malachite green and efficient adsorption of malachite green.

Multi-target detection combined with in-situ removal of contaminants is a challenging issue difficult to overcome. Herein, a dual-emissive Eu-metal organic framework (Eu-MOF) was constructed by pre-functionalization with a blue-emissive ligand and post-functionalization with red-emissive Eu ions using a UiO-66 precursor. The fluorescence of the synthesized Eu-MOF is highly selective and sensitive toward malachite green (MG) and its metabolite leuco-malachite green (LMG), which are environmentally persistent and highly toxic to humans.

Integrative pharmacology reveals the mechanisms of Erzhi pills, A traditional Chinese formulation, stimulating melanogenesis.

Ethnopharmacological Relevance: Erzhi pills (EZP), a traditional Chinese medicine formula prescribed for the treatment of vitiligo, has shown promising efficacy. However, the oral bioactive components and mechanisms underlying the promotion of melanogenesis by EZP remain unclear.

Aim Of The Study: This study aimed to investigate the pharmacological basis and mechanism of EZP in promoting melanogenesis.

Duck Tembusu virus infection activates the MKK3/6-p38 MAPK signaling pathway to promote virus replication.

Duck Tembusu virus (DTMUV) infection poses a serious threat to ducks, chickens, and geese, causing a range of detrimental effects, including reduced egg production, growth retardation, and even death. These consequences lead to substantial economic losses for the Chinese poultry industry. Although it is established that various viral infections can trigger activation of the p38 mitogen-activated protein kinase (MAPK) signaling pathway, the precise role and mechanisms underlying p38 MAPK activation in DTMUV infection remain poorly understood.

A recyclable Eu-functionalized dual-emissive metal-organic framework for portable, rapid detection and efficient removal of malachite green.

A europium-functionalized, dual-emissive, metal-organic framework-based fluorescence sensor (EuUCNDA) was constructed post-synthetic modification of an UiO-66-type precursor through coordination interactions. EuUCNDA exhibited extremely high selectivity and sensitivity for malachite green (MG) with a low detection limit of 13.01 nM, a wide linear concentration range (0.

Imaging Features of Primary Intraosseous Meningiomas.

Objective: To describe the imaging features of primary intraosseous meningiomas (PIMs) to aid an accurate diagnosis.

Methods: Clinical materials and radiological data for 9 patients with pathologically confirmed PIMs were reviewed comprehensively.

Results: Most lesions involved inner and outer plates of the calvaria and all were relatively well circumscribed.

β-Catenin and SOX2 Interaction Regulate Visual Experience-Dependent Cell Homeostasis in the Developing Thalamus.

In the vertebrate brain, sensory experience plays a crucial role in shaping thalamocortical connections for visual processing. However, it is still not clear how visual experience influences tissue homeostasis and neurogenesis in the developing thalamus. Here, we reported that the majority of SOX2-positive cells in the thalamus are differentiated neurons that receive visual inputs as early as stage 47 .

Antibacterial mechanism of vanillin against O157: H7.

Vanillin, a plant-derived antimicrobial volatile substance, has potential microbial control applications in the food industry. However, the effect of vanillin on the food-borne pathogen () O157:H7 has not been well studied. This study aims to explore the antibacterial mechanism of vanillin against O157:H7.

Enzyme-Instructed Aggregation/Dispersion of Fluorophores for Near-Infrared Fluorescence Imaging In Vivo.

Near-infrared (NIR) fluorescence is a noninvasive, highly sensitive, and high-resolution modality with great potential for in vivo imaging. Compared with "Always-On" probes, activatable NIR fluorescent probes with "Turn-Off/On" or "Ratiometric" fluorescent signals at target sites exhibit better signal-to-noise ratio (SNR), wherein enzymes are one of the ideal triggers for probe activation, which play vital roles in a variety of biological processes. In this review, we provide an overview of enzyme-activatable NIR fluorescent probes and concentrate on the design strategies and sensing mechanisms.

Caspase-3-Triggered Intracellular Gadolinium Nanoparticle Formation for T-Weighted Magnetic Resonance Imaging of Apoptosis .

Apoptosis, with a hallmark of upregulated protease Caspase-3, has been frequently imaged with various probes to reveal the therapeutic efficiencies of different drugs. However, activatable molecular probes with programmable self-assembling behaviors that enable enhanced T-weighted magnetic resonance imaging (MRI) of apoptosis remain scarce. Herein, taking advantage of a CBT-Cys click reaction, we rationally designed a Caspase-3-activatable self-assembling probe Ac-Asp-Glu-Val-Asp-Cys(StBu)-Lys(DOTA(Gd))-CBT () for apoptosis imaging .

The Teaching Strategy of Socio-Political Education by Deep Learning Under Educational Psychology.

This study aims to optimize the teaching content of ideological and political courses and guide students to establish correct values. Inspired by Artificial Intelligence, the K-means clustering algorithm was applied to the neural collaborative filtering algorithm through temporal data. Besides, a deep learning algorithm was designed for the improved matrix factorization.

[Anti-depression mechanism of Zuojin Pills:based on UHPLC-TOF-MS, network pharmacology, and experimental verification].

This study aims to explore the anti-depression mechanism of Zuojin Pills based on the plasma constituents, network pharmacology, and experimental verification. UHPLC-TOF-MS was used for qualitative analysis of Zuojin Pills-containing serum. Targets of the plasma constituents and the disease were retrieved from PharmMapper and GeneCards.

Cultural background and input familiarity influence multisensory emotion perception.

Objectives: During multisensory emotion perception, the attention devoted to the visual versus the auditory modality (i.e., modality dominance) varies depending on the cultural background of the perceiver.

Cultural Experience Influences Multisensory Emotion Perception in Bilinguals.

Emotion perception frequently involves the integration of visual and auditory information. During multisensory emotion perception, the attention devoted to each modality can be measured by calculating the difference between trials in which the facial expression and speech input exhibit the same emotion (congruent) and trials in which the facial expression and speech input exhibit different emotions (incongruent) to determine the modality that has the strongest influence. Previous cross-cultural studies have found that individuals from Western cultures are more distracted by information in the visual modality (i.

Audio-Visual Interactions During Emotion Processing in Bicultural Bilinguals.

Despite the growing number of bicultural bilinguals in the world, the way in which multisensory emotions are evaluated by bilinguals who identify with two or more cultures remains unknown. In the present study, Chinese-English bicultural bilinguals from Singapore viewed Asian or Caucasian faces and heard Mandarin or English speech, and evaluated the emotion from one of the two simultaneously-presented modalities. Reliance on the visual modality was greater when bicultural bilinguals processed Western audio-visual emotion information.

Epigenetic regulation of GABAergic differentiation in the developing brain.

In the vertebrate brain, GABAergic cell development and neurotransmission are important for the establishment of neural circuits. Various intrinsic and extrinsic factors have been identified to affect GABAergic neurogenesis. However, little is known about the epigenetic control of GABAergic differentiation in the developing brain.

Self-targeting platinum(IV) amphiphilic prodrug nano-assembly as radiosensitizer for synergistic and safe chemoradiotherapy of hepatocellular carcinoma.

Chemoradiotherapy is a widely used treatment for patients with malignancies such as hepatocellular carcinoma (HCC). However, it remains challenging to realize safe and synergistic chemotherapy and radiation sensitization. Herein, we design a self-targeting nano-assembly (STNA) based on platinum(IV)-lactose amphiphilic prodrug for synergistic and safe chemoradiotherapy of HCC.