Prognostic and chemotherapeutic implications of a novel four-gene pyroptosis model in head and neck squamous cell carcinoma.

Background: Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers. Chemotherapy remains one dominant therapeutic strategy, while a substantial proportion of patients may develop chemotherapeutic resistance; therefore, it is particularly significant to identify the patients who could achieve maximum benefits from chemotherapy. Presently, four pyroptosis genes are reported to correlate with the chemotherapeutic response or prognosis of HNSCC, while no study has assessed the combinatorial predicting efficacy of these four genes.

Salivary metabolomics of burning mouth syndrome: A cross-sectional study.

Objective: There is a lack of systematic studies on salivary metabolomic profiles in burning mouth syndrome (BMS); metabolomics could help explore BMS pathogenesis. We aimed to explore the salivary metabolomic profile of patients with BMS using untargeted metabolomics techniques.

Design: A cross-sectional study was designed to analyze the characteristics of unstimulated whole salivary metabolomics of patients with BMS (n = 34) and healthy participants (n = 30).

Association of Hashimoto's thyroiditis and anti-thyroid antibodies with oral lichen planus: A cross-sectional study.

Hashimoto's thyroiditis (HT) and its autoantibodies may be associated with oral lichen planus (OLP). In this cross-sectional study, we aimed to assess the relationship among HT, auto-anti-thyroid antibodies, and OLP in a Chinese population of 247 patients with oral lichen planus. Clinical manifestations of OLP were evaluated using the Thongprasom scoring system and clinical type.

Prevalence of oral lichen planus in patients with diabetes mellitus: A cross-sectional study.

Objectives: Oral lichen planus, a chronic inflammatory immune disease, occurs in the oral mucosa. We aimed to assess the prevalence and possible influencing factors of oral lichen planus in patients with diabetes mellitus.

Subjects And Methods: This cross-sectional study involved 525 patients with diabetes mellitus and 525 controls.

Comparison of topical antifungal agents for oral candidiasis treatment: a systematic review and meta-analysis.

Objective: To compare the efficacy and safety of topical antifungal drugs for oral candidiasis in adults and children.

Study Design: Databases were searched from their inception to December 2020. The inclusion criterion was randomized controlled trials comparing topical antifungal agents.

Application of medical magnifying loupes in diagnosis of oral mucosal diseases.

: To evaluate the application of medical magnifying loupes in diagnosis of oral mucosal diseases. Twenty-four patients with plaque-type oral lichen planus or homogeneous oral leukoplakia were inspected by naked eyes or assistance with magnifying loupes. Histopathological results were used as the gold standard to evaluate the sensitivity, specificity and accuracy of the two methods in clinical diagnosis.

Post-cesarean section pemphigus vegetans in a young woman treated with methylprednisolone and thalidomide.

Pemphigus vegetans is a rare variant of pemphigus vulgaris. Here, we report a rare case of postparturition pemphigus vegetans in a young woman without any prior medical history. The patient presented with extensive oral mucosal erosion, conjunctivitis, and fingernail dystrophy.

Efficacy of topical administration for oral lichen planus: A network meta-analysis.

Objective: To examine the comparative efficacy and safety of topical administration for oral lichen planus.

Materials And Methods: An electronic database search (1st January 1946 to 1st May 2020) for randomised controlled trials identified 34 studies involving eight interventions (clobetasol, betamethasone, triamcinolone, dexamethasone, fluocinolone, tacrolimus, pimecrolimus, and cyclosporine); these studies were subjected to network meta-analysis using direct and indirect comparisons [efficacy indicators: clinical response rate, symptom-reducing effect (visual analogue scale score), sign-reducing effect (Thongprasom-scale score) and relapse; safety indicator: adverse event occurrence].

Results: Compared with placebo, tacrolimus had the best clinical response rate (odds ratio (OR), 57.

Anxiety and oral lichen planus.

Objectives: To investigate the association between oral lichen planu(OLP) and anxiety.

Subjects And Methods: This study included 174 OLP patients and 174 healthy controls. We assessed anxiety by Self-rating Anxiety Scale (SAS) and recorded OLP lesion type and severity.

Possible Mechanisms Involved in the Cooccurrence of Oral Lichen Planus and Hashimoto's Thyroiditis.

Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disorder mediated by T cells, with a multifactorial etiology. Hashimoto's thyroiditis (HT) is a common autoimmune disease characterized by hypothyroidism. Although many clinical studies conducted over the past several decades have reported the cooccurrence of OLP and HT, the underlying mechanism remains unclear.